Geron

Geron Corporation is a biopharmaceutical company focused on discovering and developing therapeutic and diagnostic products to treat cancer and other age-related degenerative diseases. The Company is uniquely positioned to pursue this goal given its breakthrough discoveries surrounding telomeres, telomerase and embryonic stem cells. Telomeres are structures at the ends of chromosomes that the Company has shown act as a molecular "clock" of cellular aging. Telomerase is an enzyme which appears to stop the "clock" and confers cellular immortality. By manipulating telomerelength through telomerase regulation, the Company aims to kill cancer cells where telomerase is abnormally turned on. Conversely, the Company seeks to increase the lifespan of normal cells, where telomerase is normally turned off, to treat age-related diseases such as atherosclerosis, macular degeneration and osteoporosis. Embryonic stem cells are telomerase positive and therefore have an unlimited ability to divide. They have the capability to turn into any and all

cell types and tissues in the body. The Company aims to use human embryonic stem cells as a source of replacement cells for transplantation medicine to treat patients suffering from congestive heart failure, Parkinson's Disease, diabetes, osteoarthritis, osteoporosis, cancers, skin disorders and other age-related conditions.

Contact Details: 230 Constitution Drive Menlo Park CA 94025 United States of America Tel: 650 473 7700 Fax: 650 473 7750 Email: info@geron.com WWW: www.geron.com/

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Recent Publications by Geron:
Telomerase and cancer therapeutics. Telomerase is an attractive cancer target as it appears to be required in...	22nd April, 2008	Geron Corporation, 230 Constitution Drive, Menlo Park, California 94025,	Nat Rev Cancer. 2008 Mar;8(3):167-79. DOI Direct Link
Oligonucleotide conjugate GRN163L targeting human telomerase as potential anticancer and antimetastatic agent. Telomerase is one of the key enzymes responsible for the proliferative...	21st March, 2008	Geron Corporation, 230 Constitution Drive, Menlo Park, CA 94025, USA.	Nucleosides Nucleotides Nucleic Acids. 2007;26(10-12):1577-9. DOI Direct Link
Immunological properties of human embryonic stem cell-derived oligodendrocyte progenitor cells. A major concern in the use of allotransplantation of human embryonic stem...	15th March, 2008	Geron Corporation,	J Neuroimmunol. 2007 Dec;192(1-2):134-44. Epub 2007 Nov 8. DOI Direct Link
Growth and differentiation of human embryonic stem cells for cardiac cell replacement therapy. Due to the limited proliferation capacity of cardiac cells, cell...	27th February, 2008	Geron Corporation, 230 Constitution Drive, Menlo Park, CA 94025, USA.	Curr Stem Cell Res Ther. 2006 May;1(2):173-87.
Discussions by elders and adult children about end-of-life preparation and preferences. INTRODUCTION: In the United States, 73% of deaths occur among people aged...	11th January, 2008	Institute of Gerontology, College of Public Health, University of Georgia	Prev Chronic Dis. 2008 Jan;5(1):A08. Epub 2007 Dec 15.
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BioNews Results for Geron:
Process servers renew plea to court	New Jersey Lawyer Online:  Aug 29 2008 7:34PM Matching: geron
Half-yearly Report	London Stock Exchange:  Aug 29 2008 12:06PM Matching: geron
Culture system for rapid expansion of human embryonic stem cells	PharmCast:  Aug 29 2008 4:02AM Matching: geron
Geron Corp(GAAP) (GERN.GP) Weekly Earnings Information	Calibre Macro World:  Aug 24 2008 6:06AM Matching: geron
Cloning Company ViaGen Merges With Licensing Company	CattleNetwork.com:  Aug 16 2008 9:13AM Matching: geron
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Geron Patents:
US Patent No.	Title
6548741	Developmental competence for assisted reproduction and nuclear transfer in pigs
6787133	Using purified telomerase to identify telomerase activators and inhibitors
6800480	Methods and materials for the growth of primate-derived primordial stem cells in feeder-free culture
6808880	Method for detecting polynucleotides encoding telomerase
6833269	Making neural cells for human therapy or drug screening from human embryonic stem cells
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