Recent Publications by Diosynth Incorporated: |
Formulation of botulinum neurotoxin heavy chain fragments for vaccine development: mechanisms of adsorption to an aluminum-containing adjuvant.
Heavy chain fragments of botulinum neurotoxin serotypes A and B are being... | 16th November, 2005
| Department of Pharmaceutical Sciences and Stability, Diosynth
| Vaccine. 2005 Jul 1;23(31):4029-35.
DOI Direct Link |
A novel method for repetitive peptide synthesis in solution without isolation of intermediates.
A novel method was developed for the large-scale manufacture of peptides... | 16th November, 2005
| Diosynth bv, PO Box 20, 5340 BH Oss, The Netherlands.
| J Pept Sci. 2005 Oct;11(10):633-41.
DOI Direct Link |
Removal of lipopolysaccharides from protein-lipopolysaccharide complexes by nonflammable solvents.
During the recovery of recombinant proteins from gram negative bacteria,... | 1st June, 2005
| Purification Process Development Department Diosynth Biotechnology, 3000
| J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Feb
DOI Direct Link |
Effect of feed and bleed rate on hybridoma cells in an acoustic perfusion bioreactor: part I. Cell density, viability, and cell-cycle distribution.
For the development of optimal perfusion processes the effect of the feed... | 1st April, 2005
| Department of Agrotechnology and Food Sciences, Food and Bioprocess
| Biotechnol Bioeng. 2004 Dec 5;88(5):547-57.
DOI Direct Link |
Use of biophysical characterization in preformulation development of a heavy-chain fragment of botulinum serotype B: evaluation of suitable purification process conditions.
PURPOSE: The purpose of this study was to investigate the physicochemical... | 19th February, 2005
| Diosynth RTP, Inc, Cary, North Carolina 27513, USA.
| Pharm Res. 2004 Aug;21(8):1353-61.
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Ion chromatographic quantification of cyanate in urea solutions: estimation of the efficiency of cyanate scavengers for use in recombinant protein manufacturing.
The chaotrope urea is commonly used during recombinant protein... | 16th December, 2004
| Purification Process Development Department, Diosynth RTP, Inc. 3000
| J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Apr 25;803(2):353-62.
DOI Direct Link |
Identifying and modulating disulfide formation in the biopharmaceutical production of a recombinant protein vaccine candidate.
Structural conversion of the serotype A recombinant botulinum neurotoxin... | 21st April, 2004
| Diosynth RTP, Inc., 3000 Weston Parkway, Cary, NC 27513, USA.
| J Biotechnol. 2003 Aug 15;103(3):257-71.
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Initial purification of recombinant botulinum neurotoxin fragments for pharmaceutical production using hydrophobic charge induction chromatography.
Initial purification of two serotypic variants of recombinant botulinum... | 4th December, 2002
| Diosynth RTP, Inc., Cary, NC 27513, USA.
| J Chromatogr A. 2002 Apr 5;952(1-2):99-110.
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Recovery of intracellular recombinant proteins from the yeast Pichia pastoris by cell permeabilization.
A cell permeabilization method for the release of intracellular proteins... | 26th November, 2002
| Diosynth RTP, Inc, 3000 Weston Parkway, Cary, NC 27513, USA.
| J Biotechnol. 2002 Oct 23;99(2):149-60.
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