Hybridon Incorporated

Hybridon is a leader in the discovery and development of genetic drugs. These drugs are based on "antisense" technology which uses synthetic RNA and DNA that are designed to treat the underlying cause of disease by stopping or reducing the body's production of proteins that directly or indirectly cause disease. Hybridon also manufactures and sells synthetic RNA and DNA, also called oligonucleotides, to third parties on a contract basis. Hybridon's leadership in the antisense field is based on oligonucleotide technology it owns or exclusively licenses, including (a) new advanced chemistries, (b) sequence selection know-how, (c) drug development know-how, (d) innovations in the manufacturing process, (e) its fully integrated, large scale manufacturing facility and (f) its experience in manufacturing over 300 different compounds with various chemical modifications.

Contact Details: 620 Memorial Drive Cambridge MA 02139 United States of America Tel: 617 528 7000 Fax: 617 528 7001 Email: WWW: www.hybridon.com/

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Recent Publications by Hybridon Incorporated:
Chemistry of CpG DNA. The vertebrate immune system can recognize specific pathogen-associated...	28th May, 2008	Hybridon, Inc., Cambridge, Massachusetts, USA.	Curr Protoc Nucleic Acid Chem. 2003 May;Chapter 4:Unit 4.16. DOI Direct Link
Oligodeoxynucleotides containing synthetic immunostimulatory motifs augment potent Th1 immune responses to HBsAg in mice. Toll-like receptor 9 (TLR9) modulators have potent Th1-adjuvant activity....	16th August, 2005	Hybridon, Inc., 345 Vassar Street, Cambridge, MA 02139-4818, United	Int Immunopharmacol. 2005 Jun;5(6):981-91. DOI Direct Link
Immunomodulatory oligonucleotides containing a cytosine-phosphate-2'-deoxy-7-deazaguanosine motif as potent toll-like receptor 9 agonists. Bacterial DNA and synthetic oligomers containing CpG dinucleotides...	2nd August, 2005	Hybridon, Inc., 345 Vassar Street, Cambridge, MA 02139, USA.	Proc Natl Acad Sci U S A. 2005 May 10;102(19):6925-30. Epub 2005 Apr 28. DOI Direct Link
Oral administration of second-generation immunomodulatory oligonucleotides induces mucosal Th1 immune responses and adjuvant activity. CpG DNA induces potent Th1 immune responses through Toll-like receptor 9....	15th July, 2005	Hybridon, Inc., 345 Vassar Street, Cambridge, MA 02139, USA.	Vaccine. 2005 Apr 8;23(20):2614-22. DOI Direct Link
Role of Toll-like receptors in antisense and siRNA [corrected] About 25 years ago, researchers first demonstrated that a short synthetic...	13th April, 2005	Hybridon, Inc., 345 Vassar Street, Cambridge, Massachusetts 02139, USA.	Nat Biotechnol. 2004 Dec;22(12):1533-7. DOI Direct Link
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Hybridon Incorporated Patents:
US Patent No.	Title
5833944	Procedure for the solid phase synthesis of .sup.35 S-labeled oligonucleotides with 3H-1,2-benzodithiol-3-one-1,1-dioxide
5969117	Modified protein kinase a-specific oligonucleotide
5973136	Inverted chimeric oligonucleotides
6013786	MDM2-specific antisense oligonucleotides
6054439	Antisense olignucleotides having tumorigenicity-inhibiting activity
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