Recent Publications by ImmunoGen: |
Antibody-cytotoxic agent conjugates: preparation and characterization.
Conjugates of antibodies with cytotoxic agents offer a targeted... | 23rd April, 2009
| ImmunoGen Inc., Waltham, MA, USA.
| Methods Mol Biol. 2009;525:445-67, xiv.
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Targeted cancer therapy: conferring specificity to cytotoxic drugs.
The therapeutic activity of most anticancer drugs in clinical use is... | 29th May, 2008
| ImmunoGen, Inc., 128 Sidney Street, Cambridge, Massachusetts 02139, USA.
| Acc Chem Res. 2008 Jan;41(1):98-107. Epub 2007 Aug 18.
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Cell killing by antibody-drug conjugates.
Antibody-drug conjugates (ADCs) are designed to specifically bind to and... | 10th November, 2007
| ImmunoGen Inc., 128 Sidney Street, Cambridge, MA 02139-4239, USA.
| Cancer Lett. 2007 Oct 8;255(2):232-40. Epub 2007 Jun 5.
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The rabies peripheral challenge test: more accurate determination of vaccine potency.
The National Institutes of Health (NIH) rabies vaccine potency test is... | 5th January, 2007
| ImmunoGen Inc., 128 Sidney Street, Cambridge, MA 02139-4239, USA.
| Vaccine. 2006 Nov 30;24(49-50):7115-23. Epub 2006 Jul 21.
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Semisynthetic maytansine analogues for the targeted treatment of cancer.
Maytansine, a highly cytotoxic natural product, failed as an anticancer... | 12th September, 2006
| ImmunoGen, Inc., 128 Sidney Street, Cambridge, Massachusetts 02139, USA.
| J Med Chem. 2006 Jul 13;49(14):4392-408.
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Antibody-maytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing.
Antibody-drug conjugates are targeted anticancer agents consisting of a... | 8th June, 2006
| ImmunoGen, Inc., Cambridge, Massachusetts 02139, USA.
| Cancer Res. 2006 Apr 15;66(8):4426-33.
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In vivo behaviour of antibody-drug conjugates for the targeted treatment of cancer.
It is a commonly held belief that most treatments for disseminated cancers... | 7th June, 2006
| ImmunoGen, Inc.,
| Expert Opin Biol Ther. 2006 Mar;6(3):281-91.
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Antibody-drug conjugates designed to eradicate tumors with homogeneous and heterogeneous expression of the target antigen.
Conjugates of the anti-CanAg humanized monoclonal antibody huC242 with the... | 4th May, 2006
| ImmunoGen, Inc., Cambridge, Massachusetts 02139, USA.
| Cancer Res. 2006 Mar 15;66(6):3214-21.
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Drug-conjugated monoclonal antibodies for the treatment of cancer.
Early clinical development in the field of targeted delivery of cytotoxic... | 8th March, 2006
| ImmunoGen Inc,
| Curr Opin Pharmacol. 2005 Oct;5(5):543-9.
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Structural characterization of the maytansinoid-monoclonal antibody immunoconjugate, huN901-DM1, by mass spectrometry.
Immunoconjugates are being explored as novel cancer therapies with the... | 24th January, 2006
| ImmunoGen, Inc., 128 Sidney Street, Cambridge, MA 02139, USA.
| Protein Sci. 2005 Sep;14(9):2436-46. Epub 2005 Aug 4.
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Cell death suppression by cytomegaloviruses.
Cytomegaloviruses (CMVs), a subset of betaherpesviruses, employ multiple... | 13th December, 2005
| ImmunoGen, Inc., 128 Sidney St., Cambridge, MA 02139, USA.
| Apoptosis. 2005 Mar;10(2):251-65.
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Structural characterization of a recombinant monoclonal antibody by electrospray time-of-flight mass spectrometry.
PURPOSE: The aim of this study was to perform structural characterization... | 14th October, 2005
| ImmunoGen, Inc., Cambridge, Maryland 02139, USA.
| Pharm Res. 2005 Aug;22(8):1338-49. Epub 2005 Aug 3.
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Analysis of the composition of immunoconjugates using size-exclusion chromatography coupled to mass spectrometry.
Recombinant monoclonal antibody drug products play an increasingly... | 1st October, 2005
| ImmunoGen, Inc., 128 Sidney Street, Cambridge, MA 02139, USA.
| Rapid Commun Mass Spectrom. 2005;19(13):1806-14.
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Capsid structure and dynamics of a human rhinovirus probed by hydrogen exchange mass spectrometry.
Viral capsids are dynamic protein assemblies surrounding viral genomes.... | 20th September, 2005
| Department of Chemistry, University of Nebraska, Lincoln 68588-0304, USA.
| Protein Sci. 2005 Jun;14(6):1661-72. Epub 2005 May 9.
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A reversed-phase high-performance liquid chromatography method for analysis of monoclonal antibody-maytansinoid immunoconjugates.
A reversed-phase high-performance liquid chromatography (RP-HPLC) method... | 10th September, 2005
| ImmunoGen Inc., 128 Sidney Street, Cambridge, MA 02139, USA.
| Anal Biochem. 2005 May 15;340(2):272-8.
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