Gentronix helps to accelerate the pace of drug discovery by easing or removing bottlenecks in pre-clinical research. Its first product is a test to screen new pharmaceuticals for genotoxicity and cytotoxicity.
Gentronix's genotoxicity reporter system is a high-throughput eukaryotic assay that precedes the standard test battery for genotoxicity. It is a rapid, economical means of filtering out new drug candidates that would otherwise, at considerable expense, fail regulated genotoxicity testing.
Gentronix systems generate information in high-throughput mode, using standard laboratory automation, and offer the opportunity for customers to eliminate candidate compounds very early in the drug discovery process.
| Contact Details: |
| The Fairbairn Building, 72 Sackville Street |
| Manchester |
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| M60 1QD |
| United Kingdom |
| Tel: | +44 (0) 161 200 3126 |
| Fax: | +44 (0) 161 200 3052 |
| Email: | info@gentronix.co.uk |
| WWW: | www.gentronix.co.uk/
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Recent Publications by Gentronix Limited: |  |
Evaluation of high-throughput genotoxicity assays used in profiling the US EPA ToxCast chemicals.
Three high-throughput screening (HTS) genotoxicity assays-GreenScreen HC... | 14th July, 2009
| Gentronix Ltd., CTF Building, Manchester, M13 9NT, UK.
| Regul Toxicol Pharmacol. 2009 Nov;55(2):188-99. Epub 2009 Jul 8.
DOI Direct Link |
Development and validation of a higher throughput screening approach to genotoxicity testing using the GADD45a-GFP GreenScreen HC assay.
There is a pressing need to develop rapid yet accurate screening assays... | 23rd May, 2009
| Gentronix
| J Biomol Screen. 2009 Jan;14(1):16-30.
DOI Direct Link |
Assessment of the genotoxicity of S9-generated metabolites using the GreenScreen HC GADD45a-GFP assay.
Genotoxicity can be assessed by monitoring expression of a GADD45a-GFP... | 16th January, 2009
| Gentronix Ltd, Manchester, UK.
| Mutagenesis. 2009 Jan;24(1):35-50. Epub 2008 Sep 11.
DOI Direct Link |
Genotoxic carcinogen or not genotoxic carcinogen? That is the question Re: Olaharski et al., "Validation of the GreenScreen GADD45alpha-GFP indicator assay with non-proprietary and proprietary compounds".
There is a pressing need to develop rapid yet accurate screening assays... | 13th November, 2008
| University of Manchester, Faculty of Life Sciences, Manchester M13 9NT,
| Mutat Res. 2009 Jan 10;672(1):17-9. Epub 2008 Oct 19.
DOI Direct Link |
GADD45a-GFP GreenScreen HC genotoxicity screening assay.
BACKGROUND: Genetic toxicology is getting very interesting. The... | 31st October, 2008
| Gentronix Ltd, CTF Building, 46 Grafton Street, Manchester M13 9NT, UK.
| Expert Opin Drug Metab Toxicol. 2008 Jun;4(6):827-35.
DOI Direct Link |
→View more Gentronix Limited research publications. |
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