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GenVec
Download PDF Members: GenVec, Inc. (NASDAQ: GNVC) is a biopharmaceutical company developing novel gene-based therapeutic drugs and vaccines. Each of our gene-based therapeutic product candidates use a common patent-protected technology platform to deliver genes that produce medically beneficial proteins directly at the site of disease. TNFerade™ represents a novel approach to treating cancer in combination with radiation and/or chemotherapy by introducing tumor necrosis factor-alpha (TNF-alpha), a potent anti-cancer protein, directly into tumors. Pancreatic cancer is the lead indication for TNFerade™. We are conducting a 330-patient randomized, controlled Phase II/III clinical trial designed to assess the safety and clinical benefit of using TNFerade™ in combination with standard of care treatment in patients with locally advanced pancreatic cancer. Phase II trials in rectal cancer and melanoma are also ongoing. AdPEDF is being developed for patients with wet age-related macular degeneration (AMD) to determine whether pigment epithelium-derived factor (PEDF) prevents vision loss in this leading cause of blindness in people over the age of 50. We have completed a Phase I clinical trial of PEDF in patients with severe AMD. Data from this trial demonstrated that PEDF was generally well tolerated with no dose limiting toxicities. Expanded clinical testing of PEDF in AMD patients with less severe disease is ongoing. TherAtoh Atonal Therapy is a product concept to restore hearing or balance function through the regeneration of critical cells of the inner ear. Hearing and Balance require specialized cells of the inner ear called sensory hair cells. During embryonic development a gene termed atonal (ATOH) induces the generation of these cells. GenVec has shown preclinically that the production of the ATOH protein results in the formation of new inner ear sensory hair cells, and the restoration of hearing and balance function. TherAtoh is an adenovector product delivering the human atonal gene (Hath1) to trigger the production of therapeutic proteins by cells in the inner ear. We also are using GenVec's proprietary adenovector technology to develop vaccines for infectious diseases. Worldwide HIV vaccine in collaboration with the National Institute of Allergy and Infectious Diseases (NIAID) Malaria vaccine in collaboration with U.S. Navy and PATH's Malaria Vaccine Initiative Foot and Mouth Disease antiviral and vaccine program in collaboration with the United States Department of Agriculture/Agricultural Research Services (USDA-ARS) Seasonal and pandemic influenza vaccines in collaboration with the National Institute of Allergy and Infectious Diseases (NIAID) GenVec, Inc. is based in Gaithersburg, Maryland. GenVec, Inc. is based in Gaithersburg, Maryland.
This page has been viewed 855 times since April 2007, the link to the organisation's website has been followed 130 times Recent Search Terms used to find this page: cure hair cell atoh 1 2008 | genvec | Promoters influence the kinetics of transgene expression following adenovector gene delivery | genvec | genvec | PEDF cancer phase I | pedf trial cancer patients | hair cell human clinical trial ear 2008 | theratoh atonal therapy hearing loss | genvec | . Search for more companies in Gaithersburg Search for more companies in Maryland This site uses Thumbshots previews, resources from the NCBI applied. Maps are centred on zip/postcodes and should not be relied upon for exact building locations. Some information on this page has been collected automatically and may not have been verified. BioPortfolio search results for GenVec | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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