Inotek Corporation

Free radical and oxidant-mediated diseases.

Contact Details: Beverly MA United States of America Tel: Fax: Email:

Recent Publications by Inotek Corporation:
Facile and convenient syntheses of 6,11-dihydro-5H-indeno[1,2-c]isoquinolin- 5-ones and 6,11-dihydro-5H-indolo[3,2-c]isoquinolin-5-one. [reaction: see text] The synthesis of...	10th February, 2006	Inotek Pharmaceuticals Corporation, 100 Cummings Center, Beverly,	Org Lett. 2005 Apr 28;7(9):1753-6. DOI Direct Link
Mechanisms of cell necrosis. Amiloride-sensitive, epithelial Na(+) channel (ENaC)-mediated, active...	19th January, 2006	Inotek Pharmaceuticals Corporation, Beverly, MA, USA.	Crit Care Med. 2005 Dec;33(12 Suppl):S530-4.
Gender differences in the endotoxin-induced inflammatory and vascular responses: potential role of poly(ADP-ribose) polymerase activation. Activation of poly(ADP-ribose) polymerase (PARP) is an important factor in...	13th January, 2006	Inotek Pharmaceuticals Corporation, Beverly, Massachusetts, USA.	J Pharmacol Exp Ther. 2005 Nov;315(2):812-20. Epub 2005 Aug 3. DOI Direct Link
Cytokines stimulate expression of inducible nitric oxide synthase in DLD-1 human adenocarcinoma cells by activating poly(A) polymerase. OBJECTIVE: The stimulation of epithelial cells by cytokines or...	3rd November, 2005	Inotek Pharmaceuticals Corporation, 100 Cummings Center, Suite 419E,	Inflamm Res. 2004 Nov;53(11):604-8.
Angiotensin II-mediated endothelial dysfunction: role of poly(ADP-ribose) polymerase activation. Angiotensin II (AII) contributes to the pathogenesis of many...	20th October, 2005	Inotek Pharmaceuticals Corporation, Suite 419E, 100 Cummings Center,	Mol Med. 2004 Jan-Jun;10(1-6):28-35.
→View more Inotek Corporation research publications.

Inotek Corporation Clinical Trials:
A Study of INO-1001, an Intravenous PARP (Poly [ADP Ribose] Polymerase) Inhibitor in Acute Heart Attack Patients Undergoing Primary Percutaneous Coronary Intervention

Inotek Corporation Patents:
US Patent No.	Title
7432369	Pyridyl-substituted porphyrin compounds and methods of use thereof
6534651	7-Substituted isoindolinone inhibitors of inflammation and reperfusion injury and methods of use thereof
6531464	Methods for the treatment of neurodegenerative disorders using substituted phenanthridinone derivatives
6476048	Substituted phenanthridinones and methods of use thereof
6281222	Compositions and method for treatment of acetaminophen intoxication
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