Insmed

Insmed Incorporated (NASDAQ: INSM) is a biopharmaceutical company engaged in the development and commercialization of drugs to treat patients with metabolic diseases that currently have limited treatment options. The company’s lead product, IPLEXTM, approved by the FDA in December 2005, is a composition of recombinant human IGF-1 and IGFbinding protein 3. IPLEXTM is now being studied as a treatment for several serious medical conditions, including two neuromuscular disorders, Myotonic Muscular Dystrophy (MMD) and ALS (Lou Gehrig’s Disease); HIV- Associated Adipose Redistribution Syndrome (HARS); and retinopathy of prematurity (ROP). Cumulatively, these disorders affect more than 100,000 patients in the United States, and an equal number in the European Union. Insmed is also developing novel products for the treatment of cancer. INSM-18 and rhIGFBP-3 are promising potential novel treatments for a variety of cancer types. Preclinical models demonstrate that both treatments interact with the IGF system to reduce tumor growth. Headquartered in Richmond, Virginia, Insmed maintains a state-of the-art FDA-approved biologic commercial manufacturing facility, Insmed Therapeutic Proteins, in Boulder, Colorado.

Contact Details: 8720 Stony Point Parkway Suite 200 Richmond VA 23235 United States of America Tel: 804-565-3000 Fax: 804-565-3500 Email: investor@insmed.com WWW: www.insmed.com/

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Recent Publications by Insmed:
Effects of solution conditions and surface chemistry on the adsorption of three recombinant botulinum neurotoxin antigens to aluminum salt adjuvants. Botulinum neurotoxin (BoNT) is a biological warfare threat. Protein...	6th December, 2007	Department of Pharmaceutical Sciences, School of Pharmacy, University of	J Pharm Sci. 2007 Sep;96(9):2375-89. DOI Direct Link
High dietary fructose induces a hepatic stress response resulting in cholesterol and lipid dysregulation. High-fructose feeding causes diet-induced alterations of lipid metabolism...	26th February, 2004	Insmed Incorporated, 4851 Lake Brook Drive, Glen Allen, VA 23058, USA.	Endocrinology. 2004 Feb;145(2):548-55. Epub 2003 Oct 23. DOI Direct Link
D-chiro-inositol--its functional role in insulin action and its deficit in insulin resistance. In this review we discuss the biological significance of D-chiro-inositol,...	25th September, 2002	Department of Pharmacology, University of Virginia School of Medicine,	Int J Exp Diabetes Res. 2002;3(1):47-60.

BioNews Results for Insmed:
A Report on Biosimilars as a Viable Market, as the Future of the Pharmaceutical Market Lies with Biotechnology	Business Wire via Yahoo!:  Sep 26 2008 3:07PM Matching: insmed
Insmed and Premacure Cite Study Results Demonstrating Potential Effectiveness of IPLEX(TM) in Preventing Blind	KOTA Territory News:  Sep 23 2008 11:02PM Matching: insmed
Insmed and Premacure Cite Study Results Demonstrating Potential Effectiveness of IPLEX(TM) in Preventing Blind	KRON4:  Sep 23 2008 10:39PM Matching: insmed
Insmed, Premacure report positive results for trial of potential ROP treatment	OSN Super Site:  Sep 24 2008 6:23PM Matching: insmed
Insmed and Premacure Cite Study Results Demonstrating Potential Effectiveness of IPLEX(TM) in Preventing Blind	Genetic Engineering News:  Sep 23 2008 1:14PM Matching: insmed
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Insmed Patents:
US Patent No.	Title
6660891	Methods for the production of D-chiro-inositol and the use of D-chiro inositol obtained therefrom
6552085	Compositions containing hypoglycemically active stilbenoids
6541522	Methods of using compositions containing hypotriglyceridemically active stilbenoids
6492339	Compositions comprising D-chiro inositol and sulfonylureas and methods of treatment thereof
6486127	Compositions comprising D-chiro inositol and lipid lowering compounds and methods of treatment thereof
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