Recent Publications by Kaken Pharmaceutical Co Limited: |
Effects of KP-496, a novel dual antagonist at the cysteinyl leukotriene receptor 1 and the thromboxane A(2) receptor, on airway obstruction in guinea pigs.
BACKGROUND AND PURPOSE: KP-496 is a novel dual antagonist for cysteinyl... | 15th May, 2008
| Pharmacology Department, Central Research Laboratories, Kaken
| Br J Pharmacol. 2008 Feb;153(4):669-75. Epub 2007 Nov 26.
DOI Direct Link |
Preparation of rapidly disintegrating tablets containing itraconazole solid dispersions.
The disintegratability of tablets prepared from two types of solid... | 6th February, 2008
| Drug Formulation Department, Central Research Laboratories, Kaken
| Chem Pharm Bull (Tokyo). 2007 Nov;55(11):1557-62.
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Fibroblast growth factor-2-induced host stroma reaction during initial tumor growth promotes progression of mouse melanoma via vascular endothelial growth factor A-dependent neovascularization.
Fibroblast growth factor (FGF)-2 has been considered to play a critical... | 3rd May, 2007
| Safety Research Department, Central Research Laboratories, Kaken
| Cancer Sci. 2007 Apr;98(4):541-8. Epub 2007 Mar 14.
DOI Direct Link |
Effects of KP-496, a novel dual antagonist for leukotriene D4 and thromboxane A2 receptors, on contractions induced by various agonists in the guinea pig trachea.
BACKGROUND: A dry powder inhaler of KP-496 is currently in clinical... | 4th April, 2007
| Pharmacology Department, Central Research Laboratories, Kaken
| Allergol Int. 2006 Dec;55(4):403-10.
DOI Direct Link |
KP-102 (growth hormone-releasing peptide-2) attenuates ischemia/reperfusion injury in isolated rat hearts.
KP-102, a synthetic growth hormone (GH)-releasing peptide, exerts a... | 29th March, 2007
| Pharmacology Department, Central Research Laboratories, Kaken
| Naunyn Schmiedebergs Arch Pharmacol. 2006 Aug;373(5):360-6. Epub 2006 Jun
DOI Direct Link |
F2928-1 and -2, new antifungal antibiotics from Cladobotryum sp.
Two new antifungal antibiotics, F2928-1 (1) and -2 (2), were isolated from... | 22nd December, 2005
| Research Laboratory Agrochemical & Animal Health Products Department,
| J Antibiot (Tokyo). 2005 Aug;58(8):507-13.
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ACTH releasing activity of KP-102 (GHRP-2) in rats is mediated mainly by release of CRF.
KP-102 (GHRP-2: pralmorelin) is a synthetic growth hormone releasing... | 12th July, 2005
| Central Research Laboratories, Kaken Pharmaceutical Co. Ltd., 14 Shinomiya
| Naunyn Schmiedebergs Arch Pharmacol. 2005 Jan;371(1):54-60. Epub 2005 Jan
DOI Direct Link |
2,3-Diphenylpropionic acids as potent VLA-4 antagonists.
The discovery and SAR of 2,3-diphenylpropionic acid derivatives as highly... | 3rd May, 2005
| Central Research Laboratories, Kaken Pharmaceutical Co. Ltd, 14
| Bioorg Med Chem Lett. 2005 Jan 3;15(1):217-20.
DOI Direct Link |
General pharmacology of KP-102 (GHRP-2), a potent growth hormone-releasing peptide.
The general pharmacological effects of the hexapeptide KP-102... | 17th February, 2005
| Central Research Laboratories, Kaken Pharmaceutical Co., Ltd, Kyoto,
| Arzneimittelforschung. 2004;54(12):868-80.
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Pharmacological characteristics of KP-102 (GHRP-2), a potent growth hormone-releasing peptide.
KP-102... | 17th February, 2005
| Department of Pharmacology, Central Research Laboratories, Kaken
| Arzneimittelforschung. 2004;54(12):857-67.
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Reverse hydroxamate-based selective TACE inhibitors.
Reverse hydroxamate-based selective TACE inhibitors are described. They... | 5th January, 2005
| Kaken Pharmaceutical Co., Ltd, 14, Shinomiya, Minamikawara-cho, Kyoto,
| Bioorg Med Chem Lett. 2004 Jun 7;14(11):2897-900.
DOI Direct Link |
Sibutramine induces potential-dependent exocytotic release but not carrier-mediated release of dopamine and 5-hydroxytryptamine.
In order to clarify the mechanism underlying the anti-obesity effects of... | 24th September, 2004
| Central Research Institute, Kaken Pharmaceutical Co. Ltd., 14 Shinomiya
| Eur J Pharmacol. 2004 Jan 26;484(2-3):209-15.
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Paeciloxazine, a novel nematicidal antibiotic from Paecilomyces sp.
A novel nematicidal antibiotic, paeciloxazine has been isolated from the... | 21st April, 2004
| Research Laboratory Agrochemical & Animal Health Products Department,
| J Antibiot (Tokyo). 2004 Jan;57(1):24-8.
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