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karo bioKARO BIO IS AN ESTABLISHED GLOBAL LEADER IN THE FIELD OF NUCLEAR RECEPTOR RESEARCH AND DRUG DISCOVERY.
Karo Bio is committed to finding new and better pharmaceuticals that can effectively treat serious diseases without the deleterious side effects commonly experienced with today's drugs.
Karo Bio is a drug discovery company focusing its research on the discovery and pre-clinical phases of drug development. Research is conducted primarily in the area of nuclear receptors.
Nuclear receptors are proteins in the cell nucleus that act as receivers for a number of key hormones that enable the essential regulation of organs in the body. Through the understanding of nuclear receptors in drug design, new tissue selective drugs can be developed that have fewer or no side effects.
Through ongoing partnerships with outstanding academic and research institutions, such as the Karolinska Institute, home of the Nobel Prize, Karo Bio continues to be at the forefront of new discoveries to advance the Company's work with nuclear receptors and other research endeavors. With the current programs underway, Karo Bio is diligently working to discover and develop drugs for important therapeutic areas such as women's health, diabetes, inflammatory disease, obesity, cardiovascular disease, and atherosclerosis.
In addition to nuclear receptor research and development, Karo Bio also offers a novel approach to target validation and high-throughput screening with proprietary BioKey® technology. This proteomics-based drug discovery technology is ideal for the development of screens for targets of unknown function and for targets difficult to screen by traditional methods. The proprietary BioKey® technology is used for internal discovery programs and collaborative out-licensing agreements with pharmaceutical and biotechnology companies.
| Contact Details: |
| Novum 141 57 |
| Huddinge |
| Huddinge |
| 141 57 |
| Sweden |
| Tel: | ++46 8 608 6074 |
| Fax: | ++46 774 8261 |
| Email: | bo.carlsson@karobio.se |
| WWW: | www.karobio.se/
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Recent Publications by karo bio: |  |
Underlying mechanisms mediating the antidepressant effects of estrogens.
Background: There is an increased risk for depressive symptoms and... | 11th November, 2009
| Karo Bio AB, Novum SE-141 57, Huddinge, Sweden.
| Biochim Biophys Acta. 2009 Nov 6.
DOI Direct Link |
ERbeta a Novel Estrogen Receptor Offers the Potential for New Drug Development.
There is increasing interest in developing better drugs for improving the... | 15th April, 2008
| Karo Bio AB, Huddinge, Sweden.
| Trends Endocrinol Metab. 1998 Dec;9(10):387-95.
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The thyroid hormone mimetic compound KB2115 lowers plasma LDL cholesterol and stimulates bile acid synthesis without cardiac effects in humans.
Atherosclerotic cardiovascular disease is a major problem despite the... | 7th February, 2008
| Karo Bio AB, Novum Research Park, S-141 57 Huddinge, Sweden.
| Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):663-7. Epub 2007 Dec 26.
DOI Direct Link |
Thyroid receptor ligands. Part 8: Thyromimetics derived from N-acylated-alpha-amino acid derivatives displaying modulated pharmacological selectivity compared with KB-141.
Based on the scaffold of the pharmacologically selective thyromimetic 2b,... | 2nd October, 2007
| Karo Bio AB, Novum, Huddinge S-141 57, Sweden.
| Bioorg Med Chem Lett. 2007 Aug 1;17(15):4131-4. Epub 2007 May 21.
DOI Direct Link |
Thyroid receptor ligands. Part 7: Indirect antagonists of the thyroid hormone receptor with improved affinity.
Based on the concept of 'indirect antagonism' of nuclear receptors, a... | 26th July, 2007
| Karo Bio AB,
| Bioorg Med Chem Lett. 2007 Apr 1;17(7):2018-21. Epub 2007 Jan 13.
DOI Direct Link |
→View more karo bio research publications. |
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