Lexicon Genetics

Lexicon is a biopharmaceutical company focused on the discovery and development of breakthrough treatments for human disease. We use our proprietary gene knockout technology to knock out, or disrupt, the function of genes in mice and then employ an integrated platform of advanced medical technologies to systematically discover the physiological and behavioral functions and pharmaceutical utility of the genes we have knocked out and the potential drug targets encoded by the corresponding human genes. For targets that we believe have high pharmaceutical value, we engage in programs for the discovery and development of potential small molecule, antibody and protein drugs. We have advanced drug candidates from two of these programs into human clinical trials, with drug candidates from two additional programs in preclinical development and a number of additional programs in various stages of preclinical research. We have identified and validated in living mammals, or in vivo, more than 100 targets with promising profiles for drug discovery in the therapeutic areas of diabetes and obesity, cardiovascular disease, psychiatric and neurological disorders, cancer, immune system disorders and ophthalmic disease. We believe that our systematic, target biology-driven approach to drug discovery will enable us to substantially expand our clinical pipeline, and we have initiated our 10TO10 program with the goal of advancing ten drug candidates into human clinical trials by the end of 2010. We are working both independently and through strategic collaborations and alliances to capitalize on our technology and drug target discoveries and to develop and commercialize drug candidates emerging from our drug discovery and development programs. We are working with Bristol-Myers Squibb Company to discover and develop new small molecule drugs in the neuroscience field. We are working with Genentech, Inc. to discover the functions of secreted proteins and potential antibody targets identified through Genentech’s internal drug discovery research, and to develop new biotherapeutic drugs based on certain targets selected from the alliance. We are working with N.V. Organon to discover, develop and commercialize new biotherapeutic drugs based on another group of secreted proteins and potential antibody targets. We are working with Takeda Pharmaceutical Company Limited for the discovery of new drugs for the treatment of high blood pressure. In addition, we have established collaborations and license agreements with other leading pharmaceutical and biotechnology companies, research institutes and academic institutions.

Contact Details: 8800 Technology Forest Place The Woodlands TX 77381-1160 United States of America Tel: 281.863.3000 Fax: 281.863.8088 Email: WWW: www.lexicon-genetics.com/

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Recent Publications by Lexicon Genetics:
Ablation of ribosomal protein L22 selectively impairs alphabeta T cell development by activation of a p53-dependent checkpoint. The alphabeta and gammadelta T lineages are thought to arise from a common...	19th August, 2007	Division of Immunology and Hematology, Lexicon Genetics, Inc., 8800	Immunity. 2007 Jun;26(6):759-72. Epub 2007 Jun 7. DOI Direct Link
Use of a platform in an automated open-field to enhance assessment of anxiety-like behaviors in mice. The present report describes a setup for simultaneously measuring...	7th August, 2007	Lexicon Genetics Inc., Department of Neuroscience, 8800 Technology Forest	J Neurosci Methods. 2007 May 15;162(1-2):222-8. Epub 2007 Jan 26. DOI Direct Link
Regulation of innate immunity by MAPK dual-specificity phosphatases: knockout models reveal new tricks of old genes. Throughout evolution, mammals have developed an elaborate network of...	5th June, 2007	Lexicon Genetics Incorporated, 8800 Technology Forest Place, The	J Leukoc Biol. 2007 Apr;81(4):860-9. Epub 2007 Feb 8. DOI Direct Link
Obesity drugs and their targets: correlation of mouse knockout phenotypes with drug effects in vivo. Sequencing of the human genome has yielded thousands of potential drug...	18th May, 2007	Department of Endocrinology, Pharmaceutical Biology, Lexicon Genetics	Obes Rev. 2006 Feb;7(1):89-108. DOI Direct Link
Gene trap mutagenesis. Our ability to genetically manipulate the mouse has had a great impact on...	18th January, 2007	Lexicon Genetics, 8800 Technology Forest Place, The Woodlands, TX 77381,	Handb Exp Pharmacol. 2007;(178):129-47. DOI Direct Link
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BioNews Results for Lexicon Genetics:
Examine the Opportunities with Dyslipidemia in Cardiovascular Risk Reduction	Business Wire via Yahoo!:  Jul 17 2008 9:45AM Matching: lexicon genetics

Lexicon Genetics Patents:
US Patent No.	Title
6773906	Human kinase and polynucleotides encoding the same
6815188	Human kinases and polynucleotides encoding the same
6815538	Human secreted proteins and polynucleotides encoding the same
6835564	Human endothelin converting enzyme-like proteins and polynucleotides encoding the same
6838275	Human G-coupled protein receptor kinases and polynucleotides encoding the same
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