Recent Publications by Lilly Development Centre: |
Comparison of liquid chromatography and capillary electrophoresis methods for quantification of sodium residuals.
Liquid chromatography (LC) and capillary electrophoresis (CE) methods were... | 4th October, 2007
| Lilly Development Centre, Analytical Sciences R&D, Rue Granbonpre 11,
| J Pharm Biomed Anal. 2007 Jul 27;44(3):615-22. Epub 2006 Aug 22.
DOI Direct Link |
A new validation approach applied to the GC determination of impurities in organic solvents.
Organic solvents such as methanol, acetone, dichloromethane or toluene are... | 14th March, 2007
| Lilly Development Centre, Analytical Sciences R&D, rue Granbonpre 11,
| J Pharm Biomed Anal. 2006 Feb 13;40(2):294-304. Epub 2005 Sep 6.
DOI Direct Link |
Synthesis of a peroxime proliferator activated receptor (PPAR) alpha/gamma agonist via stereocontrolled Williamson ether synthesis and stereospecific SN2 reaction of S-2-chloro propionic acid with phenoxides.
The stereospecific synthesis of the PPAR alpha/gamma agonist 1 was... | 14th July, 2005
| Chemical Product Research and Development, Lilly Development Centre, rue
| J Org Chem. 2005 Jun 10;70(12):4695-705.
DOI Direct Link |
Effect of simulated intestinal fluid on drug permeability estimation across Caco-2 monolayers.
Presently, the Caco-2 cell culture model is widely used during drug... | 6th August, 2004
| Biopharmaceutics & Drug Delivery, Lilly Development Centre, 11 rue
| Int J Pharm. 2004 Apr 15;274(1-2):221-32.
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An analysis of the SFSTP guide on validation of chromatographic bioanalytical methods: progress and limitations.
The Societe Francaise des Sciences et Techniques Pharmaceutiques (SFSTP)... | 14th April, 2004
| Lilly Development Centre, Statistical and Mathematical Sciences, rue
| J Pharm Biomed Anal. 2003 Aug 8;32(4-5):753-65.
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Biological, pharmaceutical, and analytical considerations with respect to the transport media used in the absorption screening system, Caco-2.
During the evaluation and selection of drug candidates, the Caco-2 cell... | 8th April, 2004
| Biopharmaceutics and Drug Delivery, Lilly Development Centre, 11 rue
| J Pharm Sci. 2003 Aug;92(8):1545-58.
DOI Direct Link |
Effect of hepatic impairment on the pharmacokinetics of atomoxetine and its metabolites.
BACKGROUND AND OBJECTIVES: Atomoxetine is a treatment for... | 21st March, 2003
| Department of Clinical Pharmacology, Lilly Research Laboratories, Lilly
| Clin Pharmacol Ther. 2003 Mar;73(3):178-91.
DOI Direct Link |
Implementation of the caco-2 cell culture model as a predictive tool for the oral absorption of drugs. In-house evaluation procedures.
The Caco-2 cell culture model is widely used during drug development and... | 18th March, 2003
| Biopharmaceutics & Drug Delivery, Lilly Development Centre,
| J Pharm Belg. 2002 Nov-Dec;57(6):153-8.
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