Recent Publications by Menarini: |
Tachykinin receptors and gastrointestinal motility: focus on humans.
Peptides of the tachykinin (TK) family were first discovered in the... | 15th November, 2008
| Clinical Research Department, Menarini Ricerche, Florence, Italy.
| Eur Rev Med Pharmacol Sci. 2008 Aug;12 Suppl 1:69-80.
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Antitumour effect of combination treatment with Sabarubicin (MEN 10755) and cis-platin (DDP) in human lung tumour xenograft.
PURPOSE: Sabarubicin (MEN 10755), a new disaccaride anthracycline, has... | 22nd October, 2008
| Department of Pharmacology and Pharmacokinetics, Menarini Ricerche S.p.A,
| Cancer Chemother Pharmacol. 2008 Sep;62(4):621-9. Epub 2007 Nov 24.
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Excitatory and inhibitory urinary bladder reflexes induced by stimulation of cervicovaginal capsaicin-sensitive sensory fibers in rats.
We have investigated the effect of intravaginal application of capsaicin... | 8th October, 2008
| Department of Pharmacology, Menarini Ricerche S.p.A., via Rismondo 12A,
| Naunyn Schmiedebergs Arch Pharmacol. 2008 Oct 7.
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alpha,alpha-Cyclopentaneglycine dipeptides capped with biaryls as tachykinin NK(2) receptor antagonists.
The NK(2) receptor belongs to the family of tachykinin neurotransmitters.... | 8th October, 2008
| Chemistry Department, Menarini Ricerche, Via Tito Speri 10, 00040
| ChemMedChem. 2008 Jul;3(7):1048-60.
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Knee osteoarthritis: a role for bradykinin?
Osteoarthritis (OA) is a painful and degenerating progressive disease of... | 13th September, 2008
| Pharmacology Department, Menarini Ricerche S.p.A., via Rismondo 12A,
| Inflamm Res. 2008 Aug;57(8):351-61.
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Spatial and temporal expression of tachykinins and NK(1)- and NK(2)-receptor gene during TNB induced colitis in rats.
The distribution and modification of the tachykinins Substance P (SP) and... | 22nd August, 2008
| Department of Pharmacology, Menarini Ricerche S.p.A., Via Sette Santi 1,
| Neuropeptides. 2008 Aug 18.
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Synthesis, biological evaluation, and molecular modeling studies of rebeccamycin analogues modified in the carbohydrate moiety.
A new series of indolocarbazole glycosides containing disaccharides were... | 24th July, 2008
| Chemistry Department, Menarini Ricerche S.p.A. via Tito Speri 10, 00040
| ChemMedChem. 2008 Feb;3(2):266-79.
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Cinnamic acids and mono-substituted benzoic acids as useful capping groups for the preparation of hNK2 receptor antagonists.
NK(2) antagonists have been reported to be potentially useful for the... | 22nd July, 2008
| Menarini Ricerche S.p.A., via Tito Speri 10, 00040 Pomezia, Rome, Italy.
| Bioorg Med Chem Lett. 2008 Aug 15;18(16):4705-7. Epub 2008 Jul 4.
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Fragment-based approach to drug lead discovery: overview and advances in various techniques.
In the last 20 years the advent of new technologies, such as... | 1st July, 2008
| Chemistry Department, Menarini Ricerche, Pomezia, Rome, Italy.
| Drugs R D. 2008;9(4):217-27.
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Histone deacetylase inhibitors: from bench to clinic.
The NK(2) receptor belongs to the family of tachykinin neurotransmitters.... | 12th June, 2008
| Menarini Ricerche, Via Tito Speri 10, Rome, Italy.
| J Med Chem. 2008 Mar 27;51(6):1505-29. Epub 2008 Feb 5.
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Differential effect of ethanol and hydrogen peroxide on barrier function and prostaglandin E(2) release in differentiated Caco-2 cells: Selective prevention by growth factors.
The present study investigates the effects of ethanol and hydrogen... | 16th May, 2008
| Pharmacology Department, Menarini Ricerche SpA, Via Rismondo 12A, 50131
| J Pharm Sci. 2008 May 14.
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MEN16132, a kinin B2 receptor antagonist, prevents the endogenous bradykinin effects in guinea-pig airways.
Kinins have been suggested to be involved in human airway diseases such as... | 16th April, 2008
| Pharmacology Department, Menarini Ricerche S.pA.,Via Rismondo 12A, 50131
| Eur J Pharmacol. 2008 Jan 28;579(1-3):350-6. Epub 2007 Oct 25.
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Sabarubicin (MEN10755)-induced apoptosis is independent from mtDNA in A2780 human ovarian tumor cells.
BACKGROUND: The role of mitochondrial DNA (mtDNA) in anthracycline-induced... | 13th February, 2008
| Menarini Ricerche S.p.A., Via Tito Speri 10, 00040 Pomezia, Rome, Italy.
| Anticancer Res. 2007 Nov-Dec;27(6B):4039-46.
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Increased paracellular absorption by bile salts and P-glycoprotein stimulated efflux of otilonium bromide in Caco-2 cells monolayers as a model of intestinal barrier.
The present study investigates the intestinal permeability of otilonium... | 18th January, 2008
| Pharmacology Department, Menarini Ricerche SpA, Via Rismondo 12A, 50131
| J Pharm Sci. 2008 Sep;97(9):4087-100.
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Discovery of a new series of potent and selective linear tachykinin NK2 receptor antagonists.
Starting from 1 (MEN14268), a selective tachykinin NK2 receptor antagonist... | 6th December, 2007
| Menarini Ricerche S.p.a., Via dei Sette Santi 3, I-50131 Florence, Italy.
| J Med Chem. 2007 Oct 4;50(20):4793-807. Epub 2007 Sep 12.
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