Over the past quarter century, Amgen has pioneered the methods by which human proteins that play a role in disease processes are identified, isolated, produced in quantity and used as therapeutics. Today, Amgenhas research programs in inflammation, metabolic disorders and osteoporosis, neurology, oncology and hematology. The company has R&D facilities in Thousand Oaks, CA; San Francisco, CA; Cambridge, MA; Cambridge, UK; Regensburg, Germany; and Seattle, WA.
With expertise in proteins, small molecules, antibodies, peptibodies, and nucleic acids, Amgen’s scientists can pursue the study of disease, choose the best target for a disease and then use the modality most likely to have an effect on that target. This approach positions Amgen as one of the only companies with capabilities across a range of modalities.
Mastering the tools of therapeutic development, as they emerge, is crucial to Amgen’s ongoing success. Accordingly, the company has invested at least 20 percent of product sales in research and development each year since 1994—a total of approximately $2.0 billion in 2004.
| Contact Details: |
| One Amgen Center Drive |
| Thousand Oaks |
| CA |
| 91320 1799 |
| United States of America |
| Tel: | 805 447 1000 |
| Fax: | 805 447 1010 |
| Email: | |
| WWW: | www.amgen.com/
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Recent Publications by Amgen Incorporated: |  |
IL-33: a tissue derived cytokine pathway involved in allergic inflammation and asthma.
Besides classic T cell-derived T-helper type 2 (Th2) cytokines such as... | 13th November, 2009
| Department of Inflammation Research, Amgen, Seattle, WA, USA.
| Clin Exp Allergy. 2009 Nov 3.
DOI Direct Link |
Tetrahydroquinoline derivatives as CRTH2 antagonists.
A series of tetrahydroquinoline-derived inhibitors of the CRTH2 receptor... | 10th November, 2009
| Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA.
| Bioorg Med Chem Lett. 2009 Oct 25.
DOI Direct Link |
Identification of a sensitive anti-erythropoietin receptor monoclonal antibody allows detection of low levels of EpoR in cells.
Erythropoietin (Epo) binds and activates the Epo receptor (EpoR) on the... | 6th November, 2009
| Amgen Inc, One Amgen Center, Thousand Oaks, CA 91320, United States.
| J Immunol Methods. 2009 Nov 1.
DOI Direct Link |
Different Modes of Inhibitor Binding to Prolyl Hydroxylase by Combined Use of X-ray Crystallography and NMR Spectroscopy of Paramagnetic Complexes.
In aqueous solution, azaquinolone inhibitors bind to prolyl 4-hydroxylase... | 6th November, 2009
| Department of Molecular Structure, Protein Science, Chemistry Research and
| J Am Chem Soc. 2009 Nov 3.
DOI Direct Link |
Relationship between Passive Permeability, Efflux, and Predictability of Clearance from in vitro Metabolic Intrinsic Clearance.
In vitro intrinsic metabolic clearance (CL(int)) is used routinely for... | 31st October, 2009
| 1 Amgen Inc;
| Drug Metab Dispos. 2009 Oct 29.
DOI Direct Link |
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