Recent Publications by Myogen: |
A phosphorimager-based filter binding thyroid hormone receptor competition assay for chemical screening.
INTRODUCTION: A phosphorimager-based filter binding thyroid hormone... | 19th August, 2007
| Molecular Pharmacology, Myogen, Inc., Westminster, CO 80021, USA.
| J Pharmacol Toxicol Methods. 2007 Jul-Aug;56(1):28-33. Epub 2006 Dec 22.
DOI Direct Link |
Derepression of pathological cardiac genes by members of the CaM kinase superfamily.
In response to pathologic stresses such as hypertension or myocardial... | 22nd May, 2007
| Myogen, Inc./Gilead Colorado, Inc., 7575 West 103rd Ave., Westminster,
| Cardiovasc Res. 2007 Mar 1;73(4):667-77. Epub 2006 Dec 5.
DOI Direct Link |
Washout of heme-containing proteins dramatically improves tetrazolium-based infarct staining.
INTRODUCTION: Methods to determine infarct size following... | 6th April, 2007
| Inflammation Research, Amgen Inc., Seattle, WA 98119, USA.
| J Pharmacol Toxicol Methods. 2007 Mar-Apr;55(2):201-8. Epub 2006 Jul 7.
DOI Direct Link |
Randomization as a basis for inference in noninferiority trials.
Noninferiority testing in clinical trials is commonly understood in a... | 28th February, 2007
| Myogen Inc., 7575 W 103rd Ave, #102, Westminster, CO 80021, USA.
| Pharm Stat. 2006 Oct-Dec;5(4):265-71.
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Control of cardiac hypertrophy and heart failure by histone acetylation/deacetylation.
The adult heart responds to acute and chronic stresses by a remodelling... | 16th January, 2007
| Myogen, Inc., 757 W. 103rd Ave., Westminster, CO 80021, USA.
| Novartis Found Symp. 2006;274:3-12; discussion 13-9, 152-5, 272-6.
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Canonical transient receptor potential channels promote cardiomyocyte hypertrophy through activation of calcineurin signaling.
The calcium/calmodulin-dependent phosphatase calcineurin plays a central... | 12th December, 2006
| Myogen, Inc., Westminster,
| J Biol Chem. 2006 Nov 3;281(44):33487-96. Epub 2006 Sep 1.
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Protein kinase D directly phosphorylates histone deacetylase 5 via a random sequential kinetic mechanism.
Class II histone deacetylases (HDACs) are signal-responsive repressors of... | 19th August, 2006
| Research and Development, Myogen, Inc., 7575 West 103(rd) Ave.,
| Arch Biochem Biophys. 2006 Jun 15;450(2):141-8. Epub 2006 Mar 9.
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Regulation of cardiac stress signaling by protein kinase d1.
In response to pathological stresses such as hypertension or myocardial... | 10th June, 2006
| Myogen, Inc., 7575 West 103rd Ave., Westminster, Colorado 80021, USA.
| Mol Cell Biol. 2006 May;26(10):3875-88.
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Class II histone deacetylases confer signal responsiveness to the ankyrin-repeat proteins ANKRA2 and RFXANK.
Class II histone deacetylases (HDACs) contain unique amino-terminal... | 6th April, 2006
| Myogen, Westminster, CO 80021, USA.
| Mol Biol Cell. 2006 Jan;17(1):438-47. Epub 2005 Oct 19.
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The fallback procedure for evaluating a single family of hypotheses.
In testing multiple hypotheses, control of the familywise error rate is... | 13th December, 2005
| Amgen Inc., Thousand
| J Biopharm Stat. 2005;15(6):929-42.
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Toward transcriptional therapies for the failing heart: chemical screens to modulate genes.
In response to acute and chronic stresses, the heart frequently undergoes... | 10th May, 2005
| Myogen Inc., Westminster,
| J Clin Invest. 2005 Mar;115(3):538-46.
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The CRM1 nuclear export receptor controls pathological cardiac gene expression.
Diverse pathological insults trigger a cardiac remodeling process during... | 31st December, 2004
| Myogen Inc., 7575 W. 103rd Ave., Westminister, CO 80021, USA.
| Mol Cell Biol. 2004 Dec;24(24):10636-49.
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Dual roles of histone deacetylases in the control of cardiac growth.
Diverse aetiological factors, including myocardial infarction,... | 30th June, 2004
| Myogen, Inc., 7575 West 103rd Avenue, Westminster, CO 80021, USA.
| Novartis Found Symp. 2004;259:132-41; discussion 141-5, 163-9.
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A small molecular activator of cardiac hypertrophy uncovered in a chemical screen for modifiers of the calcineurin signaling pathway.
The calcium, calmodulin-dependent phosphatase calcineurin, regulates... | 18th June, 2004
| Myogen, Incorporated,
| Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2870-5. Epub 2004 Feb 19.
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Cardiac histone acetylation--therapeutic opportunities abound.
Diverse etiologic factors trigger a cardiac remodeling process in which... | 20th May, 2004
| Myogen, 7575 West 103rd Ave, Westminster, CO 80021, USA.
| Trends Genet. 2004 Apr;20(4):206-13.
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