Recent Publications by NeoPharm: |
CONVECTION-ENHANCED DELIVERY OF CINTREDEKIN BESUDOTOX (INTERLEUKIN-13-PE38QQR) FOLLOWED BY RADIATION THERAPY WITH AND WITHOUT TEMOZOLOMIDE IN NEWLY DIAGNOSED MALIGNANT GLIOMAS: PHASE 1 STUDY OF FINAL SAFETY RESULTS.
OBJECTIVE: Cintredekin besudotox (CB), a recombinant cytotoxin consisting... | 2nd October, 2008
| The Cleveland Clinic Foundation, Cleveland, Ohio (Vogelbaum) Duke
| Neurosurgery. 2008 Sep 15.
DOI Direct Link |
Synthesis of 1,3- and 1,2-diphosphatidylglycerol.
A novel phosphonium salt methodology was utilized for the first time to... | 18th July, 2007
| NeoPharm, Inc., 1850 Lakeside Drive, Waukegan, IL 60085, USA.
| Lipids. 2007 Apr;42(3):291-6. Epub 2007 Feb 7.
DOI Direct Link |
In-vitro and in-vivo anti-cancer activity of a novel gemcitabine-cardiolipin conjugate.
Our objectives were to study the biological activity of a novel... | 28th October, 2006
| Research and Development, NeoPharm Inc., Waukegan, Illinois 60085, USA.
| Anticancer Drugs. 2006 Jan;17(1):53-61.
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A novel cationic cardiolipin analogue for gene delivery.
The optically active R and S isomers of cationic cardiolipin analogues... | 11th March, 2006
| NeoPharm, Inc, Waukegan, IL 60085, USA.
| Pharmazie. 2006 Jan;61(1):10-4.
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pH-dependent association of SN-38 with lipid bilayers of a novel liposomal formulation.
The aim of this study was to determine the location of SN-38 molecules in... | 1st March, 2006
| Research & Development, NeoPharm Inc., Waukegan, IL 60085, USA.
| Int J Pharm. 2005 Aug 11;299(1-2):92-9.
DOI Direct Link |
Synthesis of cationic cardiolipin analogues.
An approach was developed to synthesize a new class of cationic... | 17th February, 2006
| Research and Development Facility, NeoPharm, Inc., 1850 Lakeside Drive,
| Bioorg Chem. 2005 Oct;33(5):345-62.
DOI Direct Link |
Synthesis and biological evaluation of gemcitabine-lipid conjugate (NEO6002).
A novel gemcitabine-lipid conjugate 5 was synthesized and tested for its... | 12th October, 2005
| NeoPharm Inc., Research and Development Facility, 1850 Lakeside Drive,
| Bioorg Med Chem Lett. 2005 May 16;15(10):2571-4.
DOI Direct Link |
Tetragenococcus koreensis sp. nov., a novel rhamnolipid-producing bacterium.
A Gram-positive, non-motile, non-spore-forming coccus (strain JS(T)) was... | 1st October, 2005
| NeoPharm Co., Ltd, BVC-307, KRIBB, 52 Oeun-dong, Yuseong-gu, Daejeon
| Int J Syst Evol Microbiol. 2005 Jul;55(Pt 4):1409-13.
DOI Direct Link |
A rapid isocratic high-performance liquid chromatography method for determination of cholesterol and 1,2-dioleoyl-sn-glycero-3-phosphocholine in liposome-based drug formulations.
A high-performance liquid chromatography (HPLC) method for the... | 19th August, 2005
| Process Development and Manufacturing Department, Research and
| J Chromatogr A. 2005 May 6;1073(1-2):347-53.
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Liquid chromatographic-tandem mass spectrometric assay for the simultaneous quantification of Camptosar and its metabolite SN-38 in mouse plasma and tissues.
A simple, rapid and sensitive LC-MS/MS bioanalytical method has been... | 19th August, 2005
| Pharmacokinetics, Safety, and Efficacy Department, Research and
| J Chromatogr A. 2005 May 6;1073(1-2):249-55.
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Separation of liposome-entrapped mitoxantrone from nonliposomal mitoxantrone in plasma: pharmacokinetics in mice.
A method is described for quantification of the liposomal and nonliposomal... | 9th August, 2005
| NeoPharm, Inc., Research and Development, Waukegan, IL 60085, USA.
| Methods Enzymol. 2005;391:176-85.
DOI Direct Link |
Systemic delivery of RafsiRNA using cationic cardiolipin liposomes silences Raf-1 expression and inhibits tumor growth in xenograft model of human prostate cancer.
Raf-1, a protein serine-threonine kinase, plays a critical role in... | 29th July, 2005
| Pharmacokinetics, Safety and Efficacy Department, NeoPharm Inc., Research
| Int J Oncol. 2005 Apr;26(4):1087-91.
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Preparation, characterization, and stability of liposome-based formulations of mitoxantrone.
The preparation, characterization, and stability of lyophilized... | 23rd July, 2005
| NeoPharm, Inc, Waukegan, Illinois, USA.
| Drug Dev Ind Pharm. 2005 Jan;31(2):223-9.
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A simple and sensitive LC/MS/MS assay for 7-ethyl-10-hydroxycamptothecin (SN-38) in mouse plasma and tissues: application to pharmacokinetic study of liposome entrapped SN-38 (LE-SN38).
An LC/MS/MS method to quantify SN-38 in mouse plasma and tissue... | 18th June, 2005
| Pharmacokinetics, Safety and Efficacy Department, Research and
| J Pharm Biomed Anal. 2005 Feb 7;37(1):135-42.
DOI Direct Link |
Preclinical safety, pharmacokinetics and antitumor efficacy profile of liposome-entrapped SN-38 formulation.
BACKGROUND: SN-38, 7-ethyl-10-hydroxycamptothecin, is a biologically... | 17th May, 2005
| NeoPharm, Inc, Research and Development, Waukegan, IL 60085, USA.
| Anticancer Res. 2005 Jan-Feb;25(1A):331-41.
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