Neurogen

Neurogen is a small molecule drug discovery and development company targeting new drug candidates to improve the lives of patients suffering from pain, insomnia, inflammation, depression, and obesity. Neurogen has generated a portfolio of compelling new drug programs through its fully integrated drug discovery platform, successfully solving complex issues in the discovery of small molecule drugs for valuable targets. Neurogen's Accelerated Intelligent Drug Discovery(AIDD) system, its expertise in cellular functional assays, and its depth in medicinal chemistry are key discriminators in the Company's ability to rapidly and cost-effectively identify new drug candidates. Our strategy is to advance a mix of proprietary drugs independently and, when advantageous, collaborate with world-class pharmaceutical companies during the drug development process to obtain additional resources and to access complementary expertise.

Contact Details: 35 Northeast Industrial Road Branford CT 06405 United States of America Tel: 203 488 8201 Fax: 203 481 8683 Email: edodge@nrgn.com WWW: www.neurogen.com/

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Recent Publications by Neurogen:
1-Benzylbenzimidazoles: The discovery of a novel series of bradykinin B(1) receptor antagonists. The design, synthesis, and structure-activity studies of a novel series of...	30th August, 2008	Neurogen Corporation, 35 NE Industrial Road, Branford, CT 06405, USA.	Bioorg Med Chem Lett. 2008 Aug 9. DOI Direct Link
D2 receptor partial agonists: treatment of CNS disorders of dopamine function. A remarkable diversity of psychiatric and neurological disorders have been...	12th August, 2008	Neurogen Corporation,	Curr Top Med Chem. 2008;8(12):1068-88.
2-Arylpyrimidines: novel CRF-1 receptor antagonists. The design, synthesis and structure-activity relationship studies of a...	2nd August, 2008	Neurogen Corporation, 35 Northeast Industrial Road, Branford, CT 06405,	Bioorg Med Chem Lett. 2008 Aug 15;18(16):4486-90. Epub 2008 Jul 18. DOI Direct Link
Aminoquinazolines as TRPV1 antagonists: modulation of drug-like properties through the exploration of 2-position substitution. A focused SAR exploration of the lead 4-aminoquinazoline TRPV1 antagonist...	30th July, 2008	Neurogen Corporation, 35 N. E. Industrial Road, Branford, CT 06405, USA.	Bioorg Med Chem Lett. 2008 Aug 15;18(16):4573-7. Epub 2008 Jul 15. DOI Direct Link
An efficient preparation of beta-aryl-beta-ketophosphonates by the TFAA/H3PO4-mediated acylation of arenes with phosphonoacetic acids. Beta-aryl-beta-ketophosphonates can be efficiently prepared in good yield...	23rd July, 2008	Process Chemistry, Neurogen Corporation, Branford, Connecticut 06405, USA.	J Org Chem. 2008 Aug 15;73(16):6397-400. Epub 2008 Jul 22. DOI Direct Link
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BioNews Results for Neurogen:
Neurogen Corporation Receives Notification from Nasdaq	SmartBrief:  Aug 27 2008 10:55PM Matching: neurogen
Neurogen Corporation Receives Notification from Nasdaq	Pharma Live:  Aug 28 2008 12:14PM Matching: neurogen
Chelsea Therapeutics receives Fast Track Designation for Droxidopa for Symptomatic Neurogenic Orthostatic Hypo	Checkbiotech:  Aug 28 2008 10:30AM Matching: neurogen
Chelsea's Droxidopa receives US FDA Fast Track status for NOH	PharmaBiz:  Aug 28 2008 1:23PM Matching: neurogen
Chelsea wins fast track designation for hypotension drug	Pharmaceutical Business Review:  Aug 28 2008 5:00AM Matching: neurogen
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Neurogen Patents:
US Patent No.	Title
6916827	Substituted ring-fused imidazole derivative: GABAA receptors ligands
7037922	Aryl fused 2,4-disubstituted pyridines: NK3 receptor ligands
7041664	2-aminoquinolinecarboxamides: neurokinin receptor ligands
7053093	Bicyclic and tricyclic hetroaromatic compounds
7060451	Methods for screening GABA-modulatory compounds for specified pharmacological activities
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