OncoImmunin, Inc. was founded by Dr. Akira Komoriya and Dr. Beverly Packard in 1994. The Company has been issued two U.S. patents on its proprietary design for protease inhibitors and fluorogenic substrates. The first PCT application has now entered into national phases in Japan and Europe and a second PCT was filed in 1998.
OncoImmunin, Inc. has designed, synthesized, validated, and patented a new class of protease substrates. Unique aspects of these molecules are: (1) incorporation of amino acid sequence information from both sides of protease cleavage sites (up to ten amino acid residues), thereby providing not only linear but three-dimensional specificity for proteases and (2) ability to cross intact cell membranes enabling measurement and inhibition of intracellular protease activities in living cells. Exploitation of elements of this latter point form the basis for OncoImmunin's patented design for the therapeutic delivery of peptide-based protease inhibitors as well as peptide-based inhibitors of other intracellular targets in sizes ranging up to twenty amino acids.
| Contact Details: |
| 207A Perry Parkway, Suite 6 |
| Gaithersburg |
| MD |
| 20877 |
| United States of America |
| Tel: | (301) 987-7881 |
| Fax: | (301) 987-7882 |
| Email: | info@phiphilux.com |
| WWW: | www.phiphilux.com/
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Recent Publications by OncoImmunin Incorporated: |  |
Intracellular protease activation in apoptosis and cell-mediated cytotoxicity characterized by cell-permeable fluorogenic protease substrates.
Over the past decade the importance of signaling from reporter molecules... | 26th March, 2008
| OncoImmunin Inc5., 207A Perry Parkway, Suite 6, Gaithersburg, MD 20877,
| Cell Res. 2008 Feb;18(2):238-47.
DOI Direct Link |
Granzyme B activity in target cells detects attack by cytotoxic lymphocytes.
Lymphocyte-mediated cytotoxicity via granule exocytosis operates by the... | 6th November, 2007
| OncoImmunin,
| J Immunol. 2007 Sep 15;179(6):3812-20.
|
Assessment of caspase activities in intact apoptotic thymocytes using cell-permeable fluorogenic caspase substrates.
To detect caspase activities in intact apoptotic cells at the single cell... | 6th August, 2000
| OncoImmunin, Incorporated, Gaithersburg, MD 20877, USA.
| J Exp Med. 2000 Jun 5;191(11):1819-28.
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OncoImmunin Incorporated
