OncoImmunin Incorporated

OncoImmunin, Inc. was founded by Dr. Akira Komoriya and Dr. Beverly Packard in 1994. The Company has been issued two U.S. patents on its proprietary design for protease inhibitors and fluorogenic substrates. The first PCT application has now entered into national phases in Japan and Europe and a second PCT was filed in 1998.

OncoImmunin, Inc. has designed, synthesized, validated, and patented a new class of protease substrates. Unique aspects of these molecules are: (1) incorporation of amino acid sequence information from both sides of protease cleavage sites (up to ten amino acid residues), thereby providing not only linear but three-dimensional specificity for proteases and (2) ability to cross intact cell membranes enabling measurement and inhibition of intracellular protease activities in living cells. Exploitation of elements of this latter point form the basis for OncoImmunin's patented design for the therapeutic delivery of peptide-based protease inhibitors as well as peptide-based inhibitors of other intracellular targets in sizes ranging up to twenty amino acids.

Contact Details: 207A Perry Parkway, Suite 6 Gaithersburg MD 20877 United States of America Tel: (301) 987-7881 Fax: (301) 987-7882 Email: info@phiphilux.com WWW: www.phiphilux.com/

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Recent Publications by OncoImmunin Incorporated:
Direct visualization of protease activity on cells migrating in three-dimensions. Determining the specific role(s) of proteases in cell migration and...	20th June, 2009	OncoImmunin, Inc., 207A Perry Parkway, Suite 6, Gaithersburg, MD 20877,	Matrix Biol. 2009 Jan;28(1):3-10. Epub 2008 Oct 29. DOI Direct Link
A method in enzymology for measuring hydrolytic activities in live cell environments. The capability of determining the physiologic role(s) of cellular enzymes...	3rd March, 2009	OncoImmunin, Inc., Gaithersburg, Maryland 20877, USA.	Methods Enzymol. 2008;450:1-19. DOI Direct Link
Intracellular protease activation in apoptosis and cell-mediated cytotoxicity characterized by cell-permeable fluorogenic protease substrates. Over the past decade the importance of signaling from reporter molecules...	26th March, 2008	OncoImmunin Inc5., 207A Perry Parkway, Suite 6, Gaithersburg, MD 20877,	Cell Res. 2008 Feb;18(2):238-47. DOI Direct Link
Granzyme B activity in target cells detects attack by cytotoxic lymphocytes. Lymphocyte-mediated cytotoxicity via granule exocytosis operates by the...	6th November, 2007	OncoImmunin,	J Immunol. 2007 Sep 15;179(6):3812-20.
Assessment of caspase activities in intact apoptotic thymocytes using cell-permeable fluorogenic caspase substrates. To detect caspase activities in intact apoptotic cells at the single cell...	6th August, 2000	OncoImmunin, Incorporated, Gaithersburg, MD 20877, USA.	J Exp Med. 2000 Jun 5;191(11):1819-28.
→View more OncoImmunin Incorporated research publications.

OncoImmunin Incorporated Patents:
US Patent No.	Title
7541143	Homo-doubly labeled compositions for the detection of enzyme activity in biological samples
6037137	Fluorogenic peptides for the detection of protease activity
5714342	Compositions for the detection of protease in biological samples and methods of use therefo
5605809	Compositions for the detection of proteases in biological samples and methods of use thereof

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