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Osiris Therapeutics

Leading the way to a better tomorrow Osiris Therapeutics, Inc. is a company founded to commercialize stem cell products from adult bone marrow. These stem cells have demonstrated the ability to repair different types of tissues. The next revolution in medical care Osiris Therapeutics is commercializing products from a readily available and non-controversial source – adult bone marrow. These stem cells have demonstrated the ability to repair different types of tissue and offer a very real opportunity to develop revolutionary new treatments for certain disease processes including autoimmune disorders, heart attacks and arthritis. Osiris’ technology is based on the pioneering work of Dr. Arnold Caplan and his colleagues at Case Western Reserve University. They showed that Mesenchymal Stem Cells (MSCs) can engraft and selectively differentiate, based on the tissue environment, to such lineages as muscle, bone, cartilage, marrow stroma, tendon and fat. Due to their cellular origin and phenotype, these cells do not provoke an immune response, allowing for the development of products derived from unrelated human donors.


Contact Details:
2001 Aliceanna Street
Baltimore
MD
21231
United States of America
Tel:410 522 5005
Fax:410 522 6999
Email:osiris@Osiris.com
WWW:

www.osiris.com/




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Recent Publications by Osiris Therapeutics:

Purification of sequence-specific DNA-binding proteins by affinity chromatography.
The affinity chromatography procedure described in this unit uses DNA...
17th June, 2008
Osiris Therapeutics, Baltimore, Maryland, USA. Curr Protoc Protein Sci. 2001 May;Chapter 9:Unit 9.6.
DOI Direct Link
Immunologic consequences of multiple, high-dose administration of allogeneic mesenchymal stem cells to baboons.
Mesenchymal stem cells (MSCs) express low immunogenicity and demonstrate...
19th June, 2007
Osiris Therapeutics, Inc., Baltimore, MD, USA. Cell Transplant. 2006;15(8-9):711-21.
Donor hematopoietic cells from transgenic mice that express GFP are immunogenic in immunocompetent recipients.
OBJECTIVE: To study the immunogenicity of hematopoietic cells marked with...
31st December, 2005
Osiris Therapeutics Inc., 2001 Aliceanna Street, Baltimore, MD 21231, USA. Hematology. 2005 Aug;10(4):289-95.
DOI Direct Link
T cell responses to allogeneic human mesenchymal stem cells: immunogenicity, tolerance, and suppression.
Human mesenchymal stem cells (MSCs) were evaluated for their ability to...
28th October, 2005
Osiris Therapeutics, Inc., 2001 Aliceanna Street, Baltimore, MD 21231, J Biomed Sci. 2005;12(1):47-57.
DOI Direct Link
A comparative study of biphasic calcium phosphate ceramics for human mesenchymal stem-cell-induced bone formation.
For the repair of bone defects, a tissue engineering approach would be to...
21st June, 2005
Osiris Therapeutics, Biomaterials. 2005 Jun;26(17):3631-8.
DOI Direct Link

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BioNews Results for Osiris Therapeutics:

Osiris Therapeutics to Present at the JMP Securities Healthcare Focus Conference
Pharma Live:  Oct 5 2008 12:33AM Matching: osiris therapeutics
ImClone Mystery Bidder Revealed
Cafepharma:  Oct 4 2008 4:54AM Matching: osiris therapeutics
Osiris Therapeutics to Present at the JMP Securities Healthcare Focus Conference
DiGiTAL50:  Oct 2 2008 7:26PM Matching: osiris therapeutics
Osiris Therapeutics to Present at the JMP Securities Healthcare Focus Conference
Yahoo!:  Oct 2 2008 12:28PM Matching: osiris therapeutics
Osiris On Prochymal Commercialization
Cafepharma:  Oct 1 2008 8:22AM Matching: osiris therapeutics
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Osiris Therapeutics Patents:

US Patent No.Title
7153500 Production of megakaryocytes by the use of human mesenchymal stem cells
6281012 Method of preparing suppressor T cells with allogeneic mesenchymal stem cells
6261549 Human mesenchymal stem cells from peripheral blood
6255112 Regulation of hematopoietic stem cell differentiation by the use of human mesenchymal stem cells
6239157 Inhibition of osteoclastogenesis

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Osiris Therapeutics (OSIR) Financial information Links from Barchart

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