Recent Publications by Achillion Pharmaceuticals: |
Internal cleavages of hepatitis C virus NS3 induced by P1 mutations at the NS3/4A cleavage site.
Despite being the focus of intensive investigation for its enzymatic... | 28th November, 2008
| Antiviral Drug Discovery, Achillion Pharmaceuticals, Inc., 300 George
| Virology. 2008 Nov 24.
DOI Direct Link |
THE EFFECT OF A SINGLE-DOSE OF RITONAVIR ON THE PHARMACOKINETIC BEHAVIOUR OF ELVUCITABINE, A NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR, WHEN ADMINISTERED IN HEALTHY VOLUNTEERS.
Purpose: To determine the effect of a single dose of 300 mg of ritonavir... | 19th November, 2008
| Faculte de Pharmacie, University of Montreal, Montreal, Canada; Achillion
| Antimicrob Agents Chemother. 2008 Nov 17.
DOI Direct Link |
THE MULTIPLE-DOSE PHARMACOKINETIC BEHAVIOUR OF ELVUCITABINE, A NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR, WHEN ADMINISTERED OVER 21 DAYS WITH LOPINAVIR/RITONAVIR IN HIV-1 SUBJECTS.
Purpose: To describe the plasma pharmacokinetics (PK) of elvucitabine at... | 19th November, 2008
| Faculte de Pharmacie, University of Montreal, Montreal, Canada; Achillion
| Antimicrob Agents Chemother. 2008 Nov 17.
DOI Direct Link |
Studying HCV RNA synthesis in vitro with replication complexes.
HCV replication complexes are well-organized protein and lipid structures... | 15th November, 2008
| Achillion Pharmaceuticals, New Haven, CT, USA.
| Methods Mol Biol. 2009;510:177-84.
DOI Direct Link |
A highly sensitive and reproducible HCV RNA hybridization method valuable for antiviral drug discovery.
Real-time RT-PCR and Northern blot are employed for the measurement of HCV... | 20th September, 2008
| Achillion Pharmaceuticals, 300 George Street, New Haven, CT 06511, USA.
| J Virol Methods. 2008 Jul;151(1):154-7. Epub 2008 May 8.
DOI Direct Link |
Selection of replicon variants resistant to ACH-806, a novel hepatitis C virus inhibitor with no cross-resistance to NS3 protease and NS5B polymerase inhibitors.
We have discovered a novel class of compounds active against hepatitis C... | 17th July, 2008
| Achillion Pharmaceuticals, New Haven, CT 06511, USA.
| Antimicrob Agents Chemother. 2008 Jun;52(6):2043-52. Epub 2008 Apr 14.
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Recent advances in bacterial topoisomerase inhibitors.
Bacterial topoisomerase inhibitors continue to be actively developed as... | 17th June, 2008
| Achillion Pharmaceuticals, Inc., 300 George Street, New Haven, CT 06511,
| Curr Opin Pharmacol. 2008 Oct;8(5):574-81. Epub 2008 Jun 12.
DOI Direct Link |
A method to assay penicillin-binding proteins.
Key enzymes that assemble the bacterial cell wall are also the target of... | 23rd May, 2008
| Achillion Pharmaceuticals, New Haven, CT, USA.
| Methods Mol Med. 2008;142:131-41.
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Dual targeting of DNA gyrase and topoisomerase IV: target interactions of heteroaryl isothiazolones in Staphylococcus aureus.
Heteroaryl isothiazolones (HITZs) are antibacterial agents that display... | 31st October, 2007
| Achillion Pharmaceuticals, New Haven, CT 06511, USA.
| Antimicrob Agents Chemother. 2007 Jul;51(7):2445-53. Epub 2007 May 14.
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Novel genetic techniques and approaches in the microbial genomics era: identification and/or validation of targets for the discovery of new antibacterial agents.
The availability of microbial genome sequences has ushered in the genomics... | 12th October, 2007
| Achillion Pharmaceuticals Inc, New Haven, CT 06511, USA.
| Drugs R D. 2007;8(4):201-12.
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Discovery of novel dialkyl substituted thiophene inhibitors of HCV by in silico screening of the NS5B RdRp.
A novel 5,4-dialkyl substituted thiophene was discovered by in silico... | 25th September, 2007
| Achillion Pharmaceuticals, 300 George Street, New Haven, CT 06511, USA.
| Bioorg Med Chem Lett. 2007 Jul 15;17(14):3905-9. Epub 2007 May 3.
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In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens.
The activities of several tricyclic heteroaryl isothiazolones (HITZs)... | 2nd August, 2007
| Achillion Pharmaceuticals, 300 George Street, New Haven, CT 06511, USA.
| Antimicrob Agents Chemother. 2007 Apr;51(4):1259-67. Epub 2007 Jan 22.
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Small molecule inhibitors of E. coli primase, a novel bacterial target.
Bacterial primase is essential for DNA replication in Gram-positive and... | 31st July, 2007
| Achillion Pharmaceuticals, 300 George Street, New Haven, CT 06511, USA.
| Bioorg Med Chem Lett. 2007 May 15;17(10):2807-10. Epub 2007 Feb 25.
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Hepatitis C virus (HCV) NS5B nonnucleoside inhibitors specifically block single-stranded viral RNA synthesis catalyzed by HCV replication complexes in vitro.
Replication complexes of hepatitis C virus synthesized two major species... | 3rd July, 2007
| Achillion Pharmaceuticals, 300 George Street, New Haven, CT 06511, USA.
| Antimicrob Agents Chemother. 2007 Jan;51(1):338-42. Epub 2006 Nov 6.
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Isothiazoloquinolones with enhanced antistaphylococcal activities against multidrug-resistant strains: effects of structural modifications at the 6-, 7-, and 8-positions.
We describe the biological evaluation of isothiazoloquinolones (ITQs)... | 10th March, 2007
| Achillion Pharmaceuticals, Inc., 300 George Street, New Haven, Connecticut
| J Med Chem. 2007 Jan 25;50(2):199-210.
DOI Direct Link |
