Applied Molecular Evolution, Inc. (AME) is a leader in the application of directed molecular evolution to improve healthcare by optimizing and developing human biotherapeutics. AME uses its proprietary AMEsystem™ directed molecular evolution technology platform to optimize genes and therapeutic proteins for specific commercial purposes. AME optimizes the full range of proteins, including antibodies, cytokines, hormones and enzymes to develop improved versions of currently marketed, FDA-approved biotherapeutics as well as novel human biopharmaceuticals.
AME has collaborations with leading developers of biotherapeutics including Centocor, Lilly, Chiron, MedImmune, Bristol-Myers Squibb, Seattle Genetics, Cell Matrix and Biosynexus, whose biopharmaceutical projects may benefit from significant optimization of therapeutic and commercial parameters including:
Improved safety, efficacy and potency
Enhanced convenience
Decreased manufacturing costs
Broadened and lengthened patents
| Contact Details: |
| 3520 Dunhill Street |
| San Diego |
| CA |
| 92121 |
| United States of America |
| Tel: | (858) 597-4990 |
| Fax: | (858) 597-4950 |
| Email: | |
| WWW: | www.amevolution.com/
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Recent Publications by Applied Molecular: |  |
Arginine vasopressin receptor gene-based single-nucleotide polymorphism analysis in attention deficit hyperactivity disorder.
Sigma(E), encoded by rpoE, causes lysis of viable but nonculturable (VBNC)... | 7th November, 2009
| Department of Molecular Genetics, Applied Molecular Genomics Group
| Psychiatr Genet. 2009 Apr;19(2):102-3.
DOI Direct Link |
Phase II Study of Preoperative Gefitinib in Clinical Stage I Non-Small-Cell Lung Cancer.
PURPOSE: Epidermal growth factor receptor (EGFR) tyrosine kinase... | 4th November, 2009
| Divisions of Medical Oncology/Hematology, Thoracic Surgery, and Chest
| J Clin Oncol. 2009 Nov 2.
DOI Direct Link |
Human papillomavirus 16 load and E2/E6 ratio in HPV16-positive women: biomarkers for cervical intraepithelial neoplasia >or=2 in a liquid-based cytology setting?
This retrospective case-control study assessed human papillomavirus 16... | 29th October, 2009
| Applied Molecular Biology Research Group, Laboratory for Cell Biology and
| Cancer Epidemiol Biomarkers Prev. 2009 Nov;18(11):2992-9. Epub 2009 Oct
DOI Direct Link |
Searching genetic risk factors for schizophrenia and bipolar disorder: learn from the past and back to the future.
For more than 20 years already, researchers from all over the world have... | 23rd October, 2009
| Applied Molecular Genomics Group, Vlaams Instituut voor Biotechnologie
| Hum Mutat. 2009 Aug;30(8):1139-52.
DOI Direct Link |
Dissection of sigma(E)-dependent cell lysis in Escherichia coli: roles of RpoE regulators RseA, RseB and periplasmic folding catalyst PpiD.
To understand the mechanism of sigma(E)-dependent cell lysis, we examined... | 23rd October, 2009
| Applied Molecular Bioscience, Graduate School of Medicine, Yamaguchi
| Genes Cells. 2009 Jul;14(7):885-99. Epub 2009 Jun 22.
DOI Direct Link |
→View more Applied Molecular research publications. |
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