Applied Molecular Evolution, Inc. (AME) is a leader in the application of directed molecular evolution to improve healthcare by optimizing and developing human biotherapeutics. AME uses its proprietary AMEsystem™ directed molecular evolution technology platform to optimize genes and therapeutic proteins for specific commercial purposes. AME optimizes the full range of proteins, including antibodies, cytokines, hormones and enzymes to develop improved versions of currently marketed, FDA-approved biotherapeutics as well as novel human biopharmaceuticals.
AME has collaborations with leading developers of biotherapeutics including Centocor, Lilly, Chiron, MedImmune, Bristol-Myers Squibb, Seattle Genetics, Cell Matrix and Biosynexus, whose biopharmaceutical projects may benefit from significant optimization of therapeutic and commercial parameters including:
Improved safety, efficacy and potency
Enhanced convenience
Decreased manufacturing costs
Broadened and lengthened patents
| Contact Details: |
| 3520 Dunhill Street |
| San Diego |
| CA |
| 92121 |
| United States of America |
| Tel: | (858) 597-4990 |
| Fax: | (858) 597-4950 |
| Email: | |
| WWW: | www.amevolution.com/
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Recent Publications by Applied Molecular: |  |
A multianalyte ELISA for immunochemical screening of sulfonamide, fluoroquinolone and ss-lactam antibiotics in milk samples using class-selective bioreceptors.
A multianalyte ELISA has been developed for the simultaneous determination... | 1st August, 2008
| Applied Molecular Receptors Group (AMRg), CSIC, CIBER of Bioengenieering,
| Anal Bioanal Chem. 2008 Jul;391(5):1703-12. Epub 2008 May 16.
DOI Direct Link |
Simultaneous immunochemical detection of stanozolol and the main human metabolite, 3'-hydroxy-stanozolol, in urine and serum samples.
Two enzyme-linked immunosorbent assays (ELISAs) have been established for... | 31st July, 2008
| Applied Molecular Receptors Group, CSIC, CIBER of Bioengineering,
| Anal Biochem. 2008 May 15;376(2):221-8. Epub 2008 Feb 19.
DOI Direct Link |
Quantitative trait loci for impaired glucose tolerance in nondiabetic SM/J and A/J mice.
The SMXA-5 recombinant inbred strain, which was established from... | 17th July, 2008
| Applied Molecular Bioscience, Graduate School of Bioagricultural Sciences,
| Physiol Genomics. 2008 Jul 15.
DOI Direct Link |
Graded hypoxia modulates the invasive potential of HT1080 fibrosarcoma and MDA MB231 carcinoma cells.
Spatial and temporal oxygen heterogeneity exists in most solid tumour... | 2nd July, 2008
| Applied Molecular Oncology Division, Ontario Cancer Institute, Princess
| Clin Exp Metastasis. 2008;25(3):253-64. Epub 2008 Jan 10.
DOI Direct Link |
The tumor microenvironment and metastatic disease.
The microenvironment of solid tumors is a heterogeneous, complex milieu... | 11th June, 2008
| Applied Molecular Oncology, Ontario Cancer Institute, Princess Margaret
| Clin Exp Metastasis. 2008 Jun 10.
DOI Direct Link |
→View more Applied Molecular research publications. |
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