Replicon Technologies Incorporated

Replicon Technologies, Inc. (RTI) is an emerging biotechnology company focused on the use of replicons, non-replicating RNA viral particles, for the treatment of patients with cancer. RTI is founded on research and development performed at the University of Alabama at Birmingham (UAB), and supported by competitive grants from the National Institutes of Health, the Department of Defense, and SBIR grants from the National Cancer Institute.

RTI’s replicons are oncolytic in a broad range of cancers, can cross the blood brain barrier, and efficiently diffuse through CNS tissue to sites of metastases. Replicons are highly selective for tumors due to up-regulation of the poliovirus receptor (CD-155) on cancer cells. Product development is focused on treatment of patients with primary brain cancers and metastases of cancers to the CNS, an area of cancer treatment for which replicons are uniquely suited due to their natural tropism for CNS tissues. The CNS is an area where current therapeutic alternatives of chemotherapy and radiation are minimally effective and cause excessive morbidity. Moreover, there are few, if any, viable new therapies in development for the specialized area of treating brain metastases or cancers to the CNS.

Contact Details: 828 Eastbrook Court Danville CA 94505-1206 United States of America Tel: (925) 736 1863 Fax: (925) 736 5910 Email: DCAnsardi@replicontechnologies.com WWW: www.replicontechnologies.com/

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Genelabs Technologies Announces Presentation of Data on Non-Nucleoside HCV Polymerase Inhibitor at 3rd Interna	Pharma Live:  Jun 6 2008 1:23PM Matching: replicon technologies

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