Ribozyme Pharmaceuticals Incorporated

Ribozyme Pharmaceuticals was founded to develop commercial products and services based upon the significant potential of "ribozymes," a discovery of Professor Thomas R. Cech for which he shared a Nobel Prize. Ribozymes, a form of ribonucleic acid ("RNA"), can selectively inhibit the protein production and genetic function associated with a specific messenger RNA ("mRNA") molecule by binding with the particular mRNA and cutting it apart. Ribozymes treat humandisease in two primary ways. First, ribozymes can be designed to inhibit abnormal gene function that causes a disease or is essential to the growth or spread of the disease. Second, ribozymes can be designed to target viruses and other infectious agents causing disease in humans. Ribozymes also are useful in identifying the function of specific genes (validating targets) and in diagnosing disease. Ribozymes can also be designed to treat animal diseases and alter traits of plants.

Contact Details: 2950 Wilderness Place Boulder CO 80301 United States of America Tel: 303 449 6500 Fax: 303 449 6995 Email: WWW: www.rpi.com/

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Recent Publications by Ribozyme Pharmaceuticals Incorporated:
Oligoribonucleotides with 2'-O-(tert-butyldimethylsilyl) groups. The chemical synthesis of oligoribonucleotides on solid support is...	15th May, 2008	Ribozyme Pharmaceuticals, Boulder, Colorado, USA.	Curr Protoc Nucleic Acid Chem. 2001 May;Chapter 3:Unit 3.6. DOI Direct Link
Strategies for oligoribonucleotide synthesis according to the phosphoramidite method. Advances in oligoribonucleotide synthesis have lagged behind those in...	15th May, 2008	Ribozyme Pharmaceuticals, Inc., Boulder, Colorado, USA.	Curr Protoc Nucleic Acid Chem. 2001 May;Chapter 3:Unit 3.5. DOI Direct Link
Synthesis of 1,4-anhydro-2-deoxy-D-ribitol derivatives from thymidine. 1,2-Dideoxyribose 5-O-succinate, a component of solid support employed in...	12th December, 2003	Ribozyme Pharmaceuticals Inc., Boulder, Colorado 80301, USA.	Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1305-7.
Synthesis of 2'-O-substituted ribonucleosides. An efficient synthesis of 2'-O-substituted ribonucleosides, including...	12th December, 2003	Ribozyme Pharmaceuticals Inc., Boulder, Colorado 80301, USA.	Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1007-9.
Scaleable and efficient synthesis of 2'-deoxy-2'-N-phthaloyl nucleoside phosphoramidites for oligonucleotide synthesis. 2'-Deoxy-2'-N-phthaloyl nucleosides were prepared from arabino nucleosides...	13th November, 2003	Department of Chemistry and Biochemistry, Ribozyme Pharmaceuticals Inc.,	Bioorg Med Chem Lett. 2002 Nov 18;12(22):3345-7.
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BioNews Results for Ribozyme Pharmaceuticals Incorporated:
NUCRYST Announces Special Meeting of Shareholders	Pharma Live:  Nov 23 2009 2:59AM Matching: pharmaceuticals
NUCRYST Announces Special Meeting of Shareholders	KLFY:  Nov 22 2009 12:21AM Matching: pharmaceuticals
Alnylam Pharmaceuticals Down 21.5% Since SmarTrend's Sell Recommendation	TradingMarkets:  Nov 21 2009 7:26PM Matching: pharmaceuticals
NUCRYST Announces Special Meeting of Shareholders	TickerTech.com:  Nov 21 2009 8:43PM Matching: pharmaceuticals
NUCRYST Announces Special Meeting of Shareholders	KSLA:  Nov 21 2009 7:19PM Matching: pharmaceuticals
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Ribozyme Pharmaceuticals Incorporated Patents:
US Patent No.	Title
6103890	Enzymatic nucleic acids that cleave C-fos
6251666	Nucleic acid catalysts comprising L-nucleotide analogs
6258585	Method and reagent for inhibiting influenza virus replication
6268534	Process for the synthesis of N,N-Dioleyl-N,N-Dimethylammonium Chloride
6280936	Method for screening nucleic acid catalysts
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