Recent Publications by Roche: |
Protein aggregation: Pathways, induction factors and analysis.
Control and analysis of protein aggregation is an increasing challenge to... | 1st October, 2008
| Formulation R&D Biologics, Pharmaceutical and Analytical R&D, F.
| J Pharm Sci. 2008 Sep 29.
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Pharmaceutical applications of vibrational chemical imaging and chemometrics: A review.
The emergence of chemical imaging (CI) has gifted spectroscopy an... | 30th September, 2008
| F. Hoffmann-La Roche A.G., Basel, Switzerland; LSIIT - UMR CNRS 7005,
| J Pharm Biomed Anal. 2008 Aug 22.
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Bayesian fitting of a logistic dose-response curve with numerically derived priors.
In this report we describe the Bayesian analysis of a logistic... | 27th September, 2008
| Biostatistics Group, F. Hoffman La-Roche, Welwyn, UK.
| Pharm Stat. 2008 Sep 25.
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Molecular mechanism of the Syk activation switch.
Many immune signaling pathways require activation of the Syk tyrosine... | 27th September, 2008
| Inflammation Discovery, Roche Palo Alto LLC, Palo Alto, CA 94301.
| J Biol Chem. 2008 Sep 25.
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Vesicular trafficking and secretion of matrix metalloproteinases-2, -9 and tissue inhibitor of metalloproteinases-1 in neuronal cells.
Matrix metalloproteinases (MMPs) are endopeptidases that cleave matrix,... | 27th September, 2008
| Neurobiologie des Interactions Cellulaires et Neurophysiopathologie
| Mol Cell Neurosci. 2008 Sep 4.
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Fatigue-induced changes in tonic vibration response (TVR) in humans: Relationships between electromyographic and biochemical events.
Fatigue-induced changes in the proprioceptive reflex loop were explored in... | 26th September, 2008
| UMR MD2, Physiologie et physiopathologie en conditions d'oxygenation
| Muscle Nerve. 2008 Sep 24.
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Evaluation of the GreenScreen GADD45alpha-GFP indicator assay with non-proprietary and proprietary compounds.
The GreenScreen GADD45alpha indicator assay has been assessed for its... | 25th September, 2008
| Non Clinical Safety, Roche Palo Alto LLC, Palo Alto, CA 94304, United
| Mutat Res. 2008 Sep 4.
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Safety and Efficacy of Enfuvirtide in Combination with Darunavir/Ritonavir and an Optimized Background Regimen in Triple-Class Experienced HIV-Infected Patients: The BLQ Study.
Enfuvirtide is the first fusion and entry inhibitor approved for the... | 24th September, 2008
| Orlando Immunology Center, Orlando, FL; Synergy Hematology Oncology Med.
| Antimicrob Agents Chemother. 2008 Sep 22.
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Design, data analysis and simulation of in vitro drug transport kinetic experiments using a mechanistic in vitro model.
The use of in vitro data for quantitative predictions of... | 24th September, 2008
| F. Hoffmann-La Roche Ltd.
| Drug Metab Dispos. 2008 Sep 22.
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Direct costs associated with the disease management of patients with unresectable advanced non-small-cell lung cancer in The Netherlands.
INTRODUCTION: Disease management and costs of treatment of patients with... | 23rd September, 2008
| Department of Commercial Affairs, Roche Netherlands BV, Woerden, The
| Lung Cancer. 2008 Sep 19.
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Design, synthesis and structure-activity relationship of simple bis-amides as potent inhibitors of GlyT1.
Several novel classes of potent and small amide-type inhibitors of glycine... | 23rd September, 2008
| F. Hoffmann-La Roche Ltd., Pharmaceutical Research Basel, Discovery
| Bioorg Med Chem Lett. 2008 Sep 6.
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Quantification of small molecules in plasma with direct analysis in real time tandem mass spectrometry, without sample preparation and liquid chromatographic separation.
Recently, a new ion source, Direct Analysis in Real Time (DART), has been... | 23rd September, 2008
| Department of Drug Metabolism and Pharmacokinetics, Roche Palo Alto, LLC,
| Rapid Commun Mass Spectrom. 2008 Sep 22;22(20):3217-3224.
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Kinetic and thermodynamic assessment of binding of serotonin transporter inhibitors.
Several serotonin re-uptake inhibitors are in clinical use for treatment... | 20th September, 2008
| Biochemical Pharmacology, Roche Pharmaceuticals.
| J Pharmacol Exp Ther. 2008 Sep 18.
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ANTIDEPRESSANTS TARGETING THE SEROTONIN REUPTAKE TRANSPORTER (SERT) ACT VIA A COMPETITIVE MECHANISM.
Although several antidepressants (including fluoxetine, imipramine,... | 20th September, 2008
| Roche Palo Alto.
| J Pharmacol Exp Ther. 2008 Sep 18.
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The Crystal Structure of JNK2 Reveals Conformational Flexibility in the MAP Kinase Insert and Indicates Its Involvement in the Regulation of Catalytic Activity.
c-Jun N-terminal kinase (JNK) 2 is a member of the mitogen-activated... | 20th September, 2008
| Discovery Technologies, Roche Palo Alto, 3431 Hillview Avenue, Palo Alto,
| J Mol Biol. 2008 Sep 10.
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