Recent Publications by Santen Incorporated: |
Altered distribution of aquaporin 5 and its C-terminal binding protein in the lacrimal glands of a mouse model for Sjogren's syndrome.
PURPOSE: To investigate the distribution and expression of aquaporin 5... | 13th August, 2008
| Department of Ophthalmology, Keio University School of Medicine, Tokyo,
| Curr Eye Res. 2008 Aug;33(8):621-9.
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Synthesis and biological evaluation of N-mercaptoacylproline and N-mercaptoacylthiazolidine-4-carboxylic acid derivatives as leukotriene A4 hydrolase inhibitors.
We studied the synthetic modification of structurally similar... | 5th August, 2008
| Nara Research & Development Center, Santen Pharmaceutical Co., Ltd,
| Bioorg Med Chem Lett. 2008 Aug 15;18(16):4529-32. Epub 2008 Jul 15.
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Ocular pharmacokinetic/pharmacodynamic modeling for multiple anti-glaucoma drugs.
We have constructed a new ocular pharmacokinetic pharmacodynamic (PK/PD)... | 2nd August, 2008
| Santen Pharmaceutical
| Biol Pharm Bull. 2008 Aug;31(8):1590-5.
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Conformation-activity relationship on novel 4-pyridylmethylthio derivatives with antiangiogenic activity.
We found 4-pyridylmethylthio derivative 1 to be very effective in using... | 17th July, 2008
| Research and Development Center, Santen Pharmaceutical Co. Ltd, 8916-16
| Bioorg Med Chem Lett. 2008 May 1;18(9):2939-43. Epub 2008 Mar 29.
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Rapid selection in chickens of subpopulations within ArkDPI-derived infectious bronchitis virus vaccines.
We examined spike (S) gene sequences of the virus populations of four... | 24th June, 2008
| Department of Pathobiology, 264 Greene Hall, College of Veterinary
| Avian Pathol. 2008 Jun;37(3):293-306.
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Ocular pharmacokinetic/pharmacodynamic modeling for timolol in rabbits using a telemetry system.
We have established an ocular pharmacokinetic/pharmacodynamic (PK/PD)... | 20th June, 2008
| Santen Pharmaceutical Co., Ltd., Nara Research and Development Center,
| Biol Pharm Bull. 2008 May;31(5):970-5.
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SA13353 (1-[2-(1-Adamantyl)ethyl]-1-pentyl-3-[3-(4-pyridyl)propyl]urea) inhibits TNF-alpha production through the activation of capsaicin-sensitive afferent neurons mediated via transient receptor potential vanilloid 1 in vivo.
Tumor necrosis factor-alpha (TNF-alpha) is known to play a crucial role in... | 30th May, 2008
| Research and Development Center, Santen Pharmaceutical Co., Ltd., 8916-16
| Eur J Pharmacol. 2008 Jul 7;588(2-3):309-15. Epub 2008 Apr 20.
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Patients do not know the level of training of their doctors because doctors do not tell them.
SETTING: Although patients should know the level of training of the... | 14th May, 2008
| Department of Higher Education Leadership, Policy Organization, Vanderbilt
| J Gen Intern Med. 2008 May;23(5):607-10. Epub 2007 Dec 21.
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Intrinsic cytotoxic effects of fluoroquinolones on human corneal keratocytes and endothelial cells.
OBJECTIVE: To determine the intrinsic cytotoxicity of five... | 29th February, 2008
| Santen Incorporated,
| Curr Med Res Opin. 2008 Feb;24(2):419-24.
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Chaperones for rectal and genital examinations in the emergency department: what do patients and physicians want?
BACKGROUND: The objective of this study was to compare patients'... | 1st February, 2008
| Department of Emergency Medicine, Vanderbilt School of Medicine,
| South Med J. 2008 Jan;101(1):24-8.
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Bucillamine mechanism inhibiting IL-1beta-induced VEGF production from fibroblast-like synoviocytes.
We investigated the bucillamine (Buc) mechanism inhibiting interleukin... | 11th January, 2008
| Research and Development Center, Santen Pharmaceutical Co., Ltd., 8916-16
| Int Immunopharmacol. 2007 Dec 5;7(12):1569-76. Epub 2007 Aug 16.
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Effects of the new ethacrynic acid oxime derivative SA12590 on intraocular pressure in cats and monkeys.
To evaluate the pharmacological characteristics of SA12590, a new... | 22nd September, 2007
| Research and Development Center, Santen Pharmaceutical Co. Ltd., 8916-16
| Biol Pharm Bull. 2007 Aug;30(8):1445-9.
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First death.
We investigated the bucillamine (Buc) mechanism inhibiting interleukin... | 13th September, 2007
| Vanderbilt University School of Medicine, Nashville, TN, USA.
| Acad Emerg Med. 2007 Sep;14(9):825-6.
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Timolol metabolism in human liver microsomes is mediated principally by CYP2D6.
Timolol has mainly been used topically for the treatment of glaucoma. It... | 25th July, 2007
| Santen Oy, Tampere, Finland.
| Drug Metab Dispos. 2007 Jul;35(7):1135-41. Epub 2007 Apr 12.
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Industrial perspective in ocular drug delivery.
In the development of a commercial drug product, the formulator must... | 16th February, 2007
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| Adv Drug Deliv Rev. 2006 Nov 15;58(11):1258-68. Epub 2006 Sep 15.
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