Scios Incorporated

Scios Inc. is a biopharmaceutical company engaged in the discovery, development, manufacture and commercialization of novel human therapeutics based upon its capabilities in both protein-based and small-molecule drug discovery and development. An NDA for the use of Natrecor(R) (nesiritide) for the short-term management of congestive heart failure ispending with the U.S. Food and Drug Administration ("FDA"). On January 29, 1999, the Cardiovascular and Renal Drugs Advisory Committee to the FDA recommended that the FDA approve Natrecor(R) for sale in the United States. Fiblast(R) (trafermin) is in Phase II/III clinical trials in Europe for stroke and the Company plans to do additional Phase II clinical trials for other vascular indications.

Contact Details: 820 West Maude Avenue Sunnyvale CA 94086 United States of America Tel: (408) 616-8200 Fax: 415 968 2438 Email: WWW: www.sciosinc.com/

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Recent Publications by Scios Incorporated:
Detection of endogenous B-type natriuretic peptide at very low concentrations in patients with heart failure. BACKGROUND: The myocardium secretes B-type natriuretic peptide (BNP) in...	11th November, 2009	Scios Inc., Mountain View, CA, USA.	Circ Heart Fail. 2008 Nov;1(4):258-64. Epub 2008 Oct 14. DOI Direct Link
The heart failure frequent flyer: an urban legend. BACKGROUND: The myocardium secretes B-type natriuretic peptide (BNP) in...	16th October, 2009	Medical Affairs, Scios	Clin Cardiol. 2009 Feb;32(2):67-8. DOI Direct Link
Heterogeneous activation of the TGFbeta pathway in glioblastomas identified by gene expression-based classification using TGFbeta-responsive genes. BACKGROUND: TGFbeta has emerged as an attractive target for the...	30th June, 2009	Biomarker R&D,	J Transl Med. 2009 Feb 3;7:12. DOI Direct Link
p38alpha-selective MAP kinase inhibitor reduces tumor growth in mouse xenograft models of multiple myeloma. Multiple myeloma (MM) is a clonal plasma cell malignancy, which is...	4th March, 2009	Scios Inc,	Anticancer Res. 2008 Nov-Dec;28(6A):3827-33.
Inhibition of p38alpha MAPK disrupts the pathological loop of proinflammatory factor production in the myelodysplastic syndrome bone marrow microenvironment. Myelodysplastic syndromes (MDS) are common causes of ineffective...	30th December, 2008	Scios Inc, Fremont, CA, USA.	Leuk Lymphoma. 2008 Oct;49(10):1963-75. DOI Direct Link
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BioNews Results for Scios Incorporated:
NewCo News	Pharmacy Choice:  Nov 5 2009 3:43PM Matching: scios
You Mean You Don't Have to Buy Them?	Corante:  Oct 28 2009 2:07PM Matching: scios
2009 Postseason Throwdown: Angel Skipper Has Answer for Heartbreaking '86 Loss to Red Sox	Orange County Weekly:  Oct 7 2009 10:11PM Matching: scios

Scios Incorporated Clinical Trials:
A Safety Study Comparing Natrecor® (Nesiritide) Versus Dobutamine Therapy for Worsening Congestive Heart Failure

Scios Incorporated Patents:
US Patent No.	Title
6476031	Quinazoline derivatives as medicaments
6800455	Secreted factors
6821966	Inhibitors of p38 kinase
6828303	Prolonged delivery of peptides
6864260	Indole-type derivatives as inhibitors of p38 kinase
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