Recent Publications by SIGA Technologies: |
Identification of a broad-spectrum arenavirus entry inhibitor.
Several arenaviruses, including Lassa virus (LASV), are causative agents... | 1st November, 2008
| SIGA Technologies, Inc., Corvallis, Oregon 97333, USA.
| J Virol. 2008 Nov;82(21):10768-75. Epub 2008 Aug 20.
DOI Direct Link |
Single-dose safety and pharmacokinetics of ST-246, a novel orthopoxvirus egress inhibitor.
ST-246 is a novel, potent orthopoxvirus egress inhibitor that is being... | 14th August, 2008
| SIGA Technologies, Inc., 4575 SW Research Way, Corvallis, OR 97330, USA.
| Antimicrob Agents Chemother. 2008 May;52(5):1721-7. Epub 2008 Mar 3.
DOI Direct Link |
Vaccination of BALB/c mice with Escherichia coli-expressed vaccinia virus proteins A27L, B5R, and D8L protects mice from lethal vaccinia virus challenge.
The potential threat of smallpox use in a bioterrorist attack has... | 16th April, 2008
| SIGA Technologies, Inc., 4575 SW Research Way, Suite 230, Corvallis, OR
| J Virol. 2008 Apr;82(7):3517-29. Epub 2008 Jan 16.
DOI Direct Link |
Discovery and development of antiviral drugs for biodefense: experience of a small biotechnology company.
The unmet need for effective antivirals against potential agents of... | 9th April, 2008
| SIGA Technologies, Inc., 4575 SW Research Way Suite 230, Corvallis, OR
| Antiviral Res. 2008 Jan;77(1):1-5. Epub 2007 Aug 15.
DOI Direct Link |
Immune responses to the smallpox vaccine given in combination with ST-246, a small-molecule inhibitor of poxvirus dissemination.
The re-emerging threat of smallpox and the emerging threat of monkeypox... | 26th March, 2008
| SIGA Technologies, 4575 SW Research Way, Suite 230, Corvallis, OR 97333,
| Vaccine. 2008 Feb 13;26(7):933-46. Epub 2007 Dec 26.
DOI Direct Link |
Discovery of small molecule inhibitors of ubiquitin-like poxvirus proteinase I7L using homology modeling and covalent docking approaches.
Essential for viral replication and highly conserved among poxviridae, the... | 12th February, 2008
| SIGA Technologies,
| J Comput Aided Mol Des. 2007 Oct-Nov;21(10-11):549-58. Epub 2007 Oct 25.
DOI Direct Link |
Comparison of transformation protocols in Streptococcus gordonii and evaluation of native promoter strength using a multiple-copy plasmid.
An active area of research in the development of Streptococcus gordonii... | 19th September, 2007
| Siga Technologies, Inc., 4575 SW Research Way, Suite 230, Corvallis, OR
| Can J Microbiol. 2007 Mar;53(3):417-26.
DOI Direct Link |
Smallpox antiviral drug development: satisfying the animal efficacy rule.
Concerns over the potential use of variola virus as a biological weapon... | 27th July, 2006
| SIGA Technologies
| Expert Rev Anti Infect Ther. 2006 Apr;4(2):277-89.
DOI Direct Link |
Vaccinia virus proteolysis--a review.
It is well known that viruses, as obligate intracellular parasites, must... | 13th July, 2006
| SIGA Technologies, Inc., Corvallis, Oregon 97333, USA.
| Rev Med Virol. 2006 May-Jun;16(3):187-202.
DOI Direct Link |
Identification and characterization of potent small molecule inhibitor of hemorrhagic fever New World arenaviruses.
Category A arenaviruses as defined by the National Institute of Allergy... | 7th June, 2006
| SIGA Technologies Inc., 4575 SW Research Way, Corvallis, OR 97333, USA.
| Antiviral Res. 2006 Feb;69(2):86-97. Epub 2005 Nov 28.
DOI Direct Link |
Listeria monocytogenes 10403S HtrA is necessary for resistance to cellular stress and virulence.
The HtrA serine protease has been shown to be essential for bacterial... | 8th February, 2006
| SIGA Technologies, 4575 NW Research Way, Corvallis, OR 97330, USA.
| Infect Immun. 2006 Jan;74(1):765-8.
DOI Direct Link |
Commensal bacteria as a novel delivery system for subunit vaccines directed against agents of bioterrorism.
Following the anthrax attacks of 2001 and the recent SARS outbreak,... | 28th September, 2005
| SIGA Technologies, Inc., 4575 SW Research Way, Suite 230, Corvallis, OR
| Adv Drug Deliv Rev. 2005 Jun 17;57(9):1392-402. Epub 2005 Apr 14.
DOI Direct Link |
Development of PLEX, a plasmid-based expression system for production of heterologous gene products by the gram-positive bacteria Streptococcus gordonii.
While Escherichia coli expression systems have been widely utilized for... | 1st July, 2005
| Siga Technologies, Inc., 4575 SW Research Way, Suite 230 Corvallis, OR
| Protein Expr Purif. 2005 Apr;40(2):319-26.
DOI Direct Link |
Escherichia coli DegP protease cleaves between paired hydrophobic residues in a natural substrate: the PapA pilin.
The DegP protein, a multifunctional chaperone and protease, is essential... | 29th October, 2002
| SIGA Technologies, Inc.,
| J Bacteriol. 2002 Oct;184(20):5762-71.
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