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ArQule IncorporatedArQule has created a new technology platform for the discovery and production of novel chemical compounds with commercial potential. The Company has developed proprietary technologies for the identification and optimizationof drug development candidates and agrochemicals. Using combinatorial chemistry, a modular building block approach to the development of compounds, structure-guided compound design, high speed parallel chemical synthesis and
information technology, the Company rapidly develops large, diverse collections of compounds that have the potential to be biologically active. To date, the Company has entered into collaborative arrangements with Abbott Laboratories, Monsanto Company, Amersham Pharmacia Biotech AB, Roche Bioscience, Solvay Duphar B.V., American Homes Products Corporation, Inc. and Sankyo Company, Ltd. and has formed joint discovery programs with many biotechnology companies.
| Contact Details: |
| 19 Presidential Way |
| Woburn |
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| 01801-5140 |
| United States of America |
| Tel: | 781 994 0300 |
| Fax: | 781-376-6019 |
| Email: | info@arqule.com |
| WWW: | www.arqule.com/
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Recent Publications by ArQule Incorporated: |  |
In vitro metabolism of beta-lapachone (ARQ 501) in mammalian hepatocytes and cultured human cells.
ARQ 501 (3,4-dihydro-2,2-dimethyl-2H-naphthol[1,2-b]pyran-5,6-dione,... | 13th March, 2009
| Department of Preclinical Development and Clinical Pharmacology, ArQule
| Rapid Commun Mass Spectrom. 2009 Jan;23(1):12-22.
DOI Direct Link |
Development and validation of a liquid chromatography-tandem mass spectrometry method for the determination of ARQ 501 (beta-lapachone) in plasma and tumors from nu/nu mouse xenografts.
A sensitive and specific LC-MS/MS method employing positive electrospray... | 29th October, 2008
| Preclinical Development Department, ArQule Inc., 19 Presidential Way,
| J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Sep 1;872(1-2):148-53.
DOI Direct Link |
Synthetic methods for the preparation of ARQ 501 (beta-Lapachone) human blood metabolites.
ARQ 501 (3,4-dihydro-2,2-dimethyl-2H-naphthol[1,2-b] pyran-5,6-dione), a... | 19th August, 2008
| ArQule Inc., 19 Presidential Way, Woburn, MA 01801, USA.
| Bioorg Med Chem. 2008 May 15;16(10):5635-43. Epub 2008 Apr 1.
DOI Direct Link |
Crystal structure of HsEg5 in complex with clinical candidate CK0238273 provides insight into inhibitory mechanism, potency, and specificity.
HsEg5 is an important mitotic kinesin responsible for bipolar spindle... | 25th July, 2008
| ArQule Biomedical Institute, ArQule Incorporated, 333 Providence Highway,
| Biochem Biophys Res Commun. 2008 Aug 8;372(4):565-70. Epub 2008 May 27.
DOI Direct Link |
Identification of a novel glucosylsulfate conjugate as a metabolite of 3,4-dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione (ARQ 501, beta-lapachone) in mammals.
3,4-Dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione (ARQ 501) is a... | 24th June, 2008
| Department of Preclinical Development and Clinical Pharmacology, ArQule
| Drug Metab Dispos. 2008 Apr;36(4):753-8. Epub 2008 Jan 28.
DOI Direct Link |
→View more ArQule Incorporated research publications. |
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