Recent Publications by Synergen Incorporated: |
Phase-I-study of four different schedules of pemetrexed, gemcitabine and cisplatin in patients with locally advanced or metastatic solid tumours.
This non-randomised Phase-I-study determined recommended dose (RD) and... | 23rd September, 2008
| St Georg Hospital III, Department of Medicine, Hamburg, Germany.
| Eur J Cancer. 2008 Nov;44(16):2444-52. Epub 2008 Sep 18.
DOI Direct Link |
Correlations of mRNA expression and in vitro chemosensitivity to enzastaurin in freshly explanted human tumor cells.
PURPOSE: Enzastaurin (LY317615) is a novel serine/threonine kinase... | 29th July, 2008
| St. Georg Hospital, Lohmuhlenstr. 5, 20099 Hamburg, Germany.
| Invest New Drugs. 2008 Jun;26(3):215-22. Epub 2007 Nov 14.
DOI Direct Link |
In vitro chemosensitivity of freshly explanted tumor cells to pemetrexed is correlated with target gene expression.
AIM OF THE STUDY: mRNA expression of genes involved in the mechanism of... | 6th November, 2007
| Asklepios Klinik, St. Georg, Lohmuhlenstr. 5, 20099 Hamburg, Germany.
| Invest New Drugs. 2007 Oct;25(5):417-23. Epub 2007 May 30.
DOI Direct Link |
Phase 1b dose escalation study of erlotinib in combination with infusional 5-Fluorouracil, leucovorin, and oxaliplatin in patients with advanced solid tumors.
PURPOSE: Erlotinib (Tarceva) is a potent epidermal growth factor receptor... | 25th April, 2007
| Department of Medicine, Asklepios Hospital St. Georg, D-20099 Hamburg,
| Clin Cancer Res. 2007 Jan 15;13(2 Pt 1):523-31.
DOI Direct Link |
Translational research with pemetrexed in breast cancer.
Pemetrexed (Alimta) is a novel folate antimetabolite that primarily... | 4th February, 2005
| AK St. Georg, Department of Medicine, Hamburg, Germany.
| Oncology (Williston Park). 2004 Nov;18(13 Suppl 8):66-9.
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Overview of phase I/II pemetrexed studies.
Pemetrexed (Alimta) is an antifolate that is effective in the inhibition... | 4th February, 2005
| AK St. Georg, Department of Medicine, Hamburg, Germany.
| Oncology (Williston Park). 2004 Nov;18(13 Suppl 8):18-25.
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The role of Alimta in the treatment of malignant pleural mesothelioma: an overview of preclinical and clinical trials.
Malignant pleural mesothelioma (MPM) is a rare tumor, but its annual... | 20th October, 2004
| Allgem. Krankenhaus St. Georg, Lohmuhlenstrasse 5, 20099 Hamburg, Germany.
| Lung Cancer. 2004 Aug;45 Suppl 1:S121-4.
DOI Direct Link |
The role of protein kinase C-alpha (PKC-alpha) in cancer and its modulation by the novel PKC-alpha-specific inhibitor aprinocarsen.
As our understanding of tumorigenesis increases, interference with the... | 21st July, 2004
| Department of Medicine, AK St. Georg, Lohmuhlenstrasse 5, D-20099 Hamburg,
| Curr Pharm Des. 2004;10(16):1923-36.
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Protective effect of the interleukin-1 receptor antagonist (IL-1ra) on experimental allergic encephalomyelitis in rats.
Cytokines such as interleukin-1 (IL-1) are thought to contribute to the... | 1st June, 2000
| Department of Pharmacology, Synergen Inc., Boulder, CO 80301, USA.
| J Neuroimmunol. 1995 Sep;61(2):241-5.
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