Recent Publications by Synt:em: |
Applications of a blood-brain barrier technology platform to predict CNS penetration of various chemotherapeutic agents. 2. Cationic peptide vectors for brain delivery.
BACKGROUND: SynB family peptides conjugated to several drugs have been... | 17th March, 2007
| Synt:em,
| Chemotherapy. 2007;53(1):73-6. Epub 2007 Jan 3.
DOI Direct Link |
Applications of a blood-brain barrier technology platform to predict CNS penetration of various chemotherapeutic agents. 1. Anti-infective drugs.
Except for a few well-documented CNS therapeutics, quantitative data on... | 17th March, 2007
| Synt:em,
| Chemotherapy. 2007;53(1):70-2. Epub 2007 Jan 3.
DOI Direct Link |
Improved brain uptake and pharmacological activity profile of morphine-6-glucuronide using a peptide vector-mediated strategy.
Morphine-6-glucuronide (M6G), an active metabolite of morphine, has been... | 6th July, 2005
| Synt:em, Parc Scientifique Georges Besse, Nimes, France.
| J Pharmacol Exp Ther. 2005 May;313(2):712-9. Epub 2005 Jan 12.
DOI Direct Link |
Peptide-vector strategy bypasses P-glycoprotein efflux, and enhances brain transport and solubility of paclitaxel.
We present the results obtained with paclitaxel coupled to a... | 29th June, 2005
| Synt:em, Institut de Genetique Moleculaire de Montpellier, CNRS UMR 5535,
| Anticancer Drugs. 2004 Nov;15(10):947-54.
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The use of cell-penetrating peptides for drug delivery.
In the past decade, several peptides that can translocate cell membranes... | 22nd December, 2004
| Synt:em, Parc Scientifique Georges Besse, 30000 Nimes, France.
| Drug Discov Today. 2004 Dec 1;9(23):1012-9.
DOI Direct Link |
Cheminformatics--decision making in drug discovery.
Biological membranes normally restrict the passage of hydrophilic... | 1st October, 2004
| Vice President R&D, Computational Drug Discovery, Synt:em, Parc
| Drug Discov Today. 2002 Sep 1;7(17):898-900.
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2-Pyrrolinodoxorubicin and its peptide-vectorized form bypass multidrug resistance.
A well-known mechanism leading to the emergence of multidrug-resistant... | 19th August, 2004
| Synt:em, Parc Scientifique Georges Besse, 30000 Nimes, France.
| Anticancer Drugs. 2004 Jul;15(6):609-17.
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D-LogP: an alignment-free 3D description of local lipophilicity for QSAR studies.
The major hurdle to overcome in the development of 3D-QSAR models using... | 29th July, 2004
| Synt:em, Nimes, France.
| Methods Mol Biol. 2004;275:215-60.
DOI Direct Link |
Blood-brain barrier permeation models: discriminating between potential CNS and non-CNS drugs including P-glycoprotein substrates.
The aim of this article is to present the design of a large heterogeneous... | 20th March, 2004
| Synt:em, Parc Scientifique G Besse, 30000 Nimes, France.
| J Chem Inf Comput Sci. 2004 Jan-Feb;44(1):239-48.
DOI Direct Link |
Peptide vectors as drug carriers.
The aim of this article is to present the design of a large heterogeneous... | 30th January, 2004
| Synt:em, Parc Scientifique Georges Besse, 30000 Nimes, France.
| Prog Drug Res. 2003;61:221-38.
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Studies on the internalization mechanism of cationic cell-penetrating peptides.
A great deal of data has been amassed suggesting that cationic peptides... | 11th November, 2003
| Synt:em, Institut de Genetique Moleculaire, 1919 Route de Mende, 34293
| J Biol Chem. 2003 Aug 15;278(33):31192-201. Epub 2003 Jun 3.
DOI Direct Link |
A peptide mimetic of an anti-CD4 monoclonal antibody by rational design.
The development of rational methods to design 'continuous' sequence... | 4th September, 2003
| Synt:em, Parc Scientifique Georges Besse, FR-30035 1, Ni;mes Cedex,
| Biochem Biophys Res Commun. 2003 Jul 18;307(1):198-205.
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Improved brain uptake and pharmacological activity of dalargin using a peptide-vector-mediated strategy.
The blood-brain barrier restricts the passage of substances into the... | 25th July, 2003
| Synt:em, Parc Scientifique Georges Besse, 30000 Nimes, France.
| J Pharmacol Exp Ther. 2003 Jul;306(1):371-6. Epub 2003 Apr 7.
DOI Direct Link |
Peptide delivery to the brain via adsorptive-mediated endocytosis: advances with SynB vectors.
Biological membranes normally restrict the passage of hydrophilic... | 1st April, 2003
| Synt:em, Parc Scientifique Georges Besse, Nimes, France.
| AAPS PharmSci. 2002;4(4):E26.
DOI Direct Link |
Improved brain delivery of benzylpenicillin with a peptide-vector-mediated strategy.
Previous studies from our laboratory have demonstrated that the coupling... | 27th December, 2002
| Synt:em, Parc Scientifique Georges Besse, Nimes, France.
| J Drug Target. 2002 Jun;10(4):309-15.
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