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ABN AMRO Capital Life Sciences leads € 22 million investment in Amsterdam Molecular Therapeutics BV

AMSTERDAM, The Netherlands - October 4, 2006: ABN AMRO Capital Life Sciences (AAC LS) announced that is has led a €22 million Series A financing of Amsterdam Molecular Therapeutics BV (AMT). The syndicate was completed by Advent Venture Partners of the UK, Gilde Investment Management and Crédit Agricole Private Equity (France).

Sander Slootweg from ABN AMRO Capital Life Sciences has joined the Company’s Supervisory Board.

Founded in 1998 on the initiative of researchers from the Academic Medical Center (AMC) in Amsterdam, AMT aspires to use its scientific know-how and expertise in the area of gene therapy in order to successfully develop innovative treatments for patients with serious inherited, metabolic or central nervous disorders.

AMT’s lead product candidate AMT-011, has been granted Orphan Drug Designation by the European Medicines Agency (EMEA) for the indication of Genetic lipoprotein lipase (LPL) deficiency (also known as type I hyperlipoproteinemia), and is currently in phase II. The proceeds of this round will be used to take the clinical development of AMT’s lead product AMT-011 through to registration. Additionally, the funds will allow the Company to accelerate its preclinical gene therapy programmes for two metabolic orphan diseases (acute intermittent porphyria and hyperoxaluria) addressing a significant unmet medical need; as well as a gene therapy to treat a rare and very serious and rapidly progressive retinal blindness.

"This financing provides AMT and collaborators, employees and shareholders with a solid foundation on which the Company can grow its core business on an accelerated timetable," said Ronald H.W. Lorijn, MD, PhD, M.B.A., Chief Executive Officer of AMT.

Commenting on the funding, Sander Slootweg, a director with AAC LS said “We have always been firm believers of Gene Therapy as a potential cure for many currently untreatable diseases. AMT-011 may actually be the first real Gene Therapy to be available to patients in the Western world. Although it initially addresses a modest market in terms of numbers of patients, the revenue potential of AMT-011 is significant, especially when considering the larger LPL type V market that can be targeted with the same product.”

Dr. Christina Takke, Senior Analyst at AAC LS, remarked: “This investment adds to a series of recent investments endorsing our investment philosophy of supporting companies with defined development candidates supported by an unique technology and clearly visible value creating milestones in the near future. We are looking forward to working together with the management and building up an important player in this field.”

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About ABN AMRO Capital Life Sciences

ABN AMRO Capital/Life Sciences (AAC LS) is the venture arm of ABN AMRO Bank N.V. of the Netherlands. AAC LS builds and finances life sciences companies that develop world-class technology with a clear focus on products for orphan as well as major markets. AAC LS has been operating in the European market since 1997 and has invested in more than 30 innovative Life Sciences companies in both Europe and the US. Further the AAC LS team was instrumental in exiting 13 investments either through IPO, trade sale or M&A and has achieved considerable success and above average returns.

For further information, go to www.abnamrocapital.com 

For more information, please contact:

At ABN AMRO Capital:

Life Sciences Team

Postbus 5187

1410 AD Naarden

The Netherlands

Tel.: + 31 (0) 35 699 3000

Fax: + 31 (0) 35 699 3001

Email: justa.van.slooten@abnamro-lifesciences.com

Media enquiries:

Annabel Entress, +44 (0)20 3008 7557 / a.entress@northbankcommunications.com

Adam Michael, +44 (0)20 3008 7554/ a.michael@northbankcommunications.com

At Amsterdam Molecular Therapeutics:

André Verwei, CFO

Phone: +31 (0)20 5667394

Email:a.f.verwei@amtbv.com

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