DYNAL Bead Based Separations Powerful new tool to revolutionise immunotherapy

 High resolution image is available from clarer@alto-marketing.com

July 16 2006 : OSLO, Norway. Dynal, now part of Invitrogen Corporation, announced today the release of a new key research tool in its immunotherapy range - Dynabeads® ClinExVivo™ CD3/CD28. Using this cutting edge technology, researchers can isolate and collect T cells from immuno-compromised patients for ex vivo stimulation and expansion in a sterile environment. In the US, Dynabeads® ClinExVivo™ CD3/CD28 are available for clinical applications only under an approved IND application.


Dynabeads® ClinExVivo™ CD3/CD28 superparamagnetic beads are designed with an optimised surface covered with primary CD3 and co-stimulatory CD28 antibodies. Following a short ex vivo incubation with the patient’s sample, the beads bind with the T cells. The beads and bound T cells are separated from the rest of the sample using the special Dynal ClinExVivo™ MPC® magnet. Researchers then stimulate and expand the T cells ex vivo with Dynabeads® ClinExVivo™ CD3/CD28 in a sterile environment prior to reintroduction to the patient. Boosted T cells, if reinfused, have the potential to strengthen the individual’s immune system to fight diseases, for example cancer and HIV.

According to International Product Manager, Erik Ruud, the new Dynabeads® ClinExVivo™ CD3/CD28 open a wide range of exciting possibilities: “Already this innovative technology has been used for several phase I/II trials in cancer patients. Data from studies using ex vivo manipulated T cells in cancer and vaccine therapy were recently presented at the International Society for Cell Therapy (ISCT) conference during a special symposium on “T Cell-based Immunotherapeutic Strategies.” This technology has further potential in auto-immune diseases as well as gene and stem cell applications.
www.invitrogen.com/clinexvivo

ENDS

Notes to editors: Dynal is the pioneer of biomagnetic separation technology and holds the original patents for monodisperse superparamagnetic beads. Today, the Dynabeads® product portfolio supports cell separation for basic and clinical research, genomics, transcriptomics, proteomics, diagnostics and more. In addition, Dynal offers tailor-made products to large volume users.

What Are Dynabeads®?

· The beads are superparamagnetic: that is, they exhibit magnetic properties only when placed within a magnetic field and show no residual magnetism when removed from this field.

· The polymer shell of the beads protects targets from toxic exposure to iron.

· The true uniformity (CV<3%) of size, shape and surface area provides optimal accessibility and reaction kinetics, allowing for rapid and efficient binding.

· The true spherical shape and defined surface chemistry minimise chemical agglutination and non-specific binding.

· Unique batch-to-batch reproducibility (typically within 5%) secures the reproducibility and quality of results.

· The specific characteristics of the many available bead types facilitate magnetic separation of a wide variety of targets.

· Separation is gentle and no column or centrifugations are necessary.