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Inpharmatica licenses Biopendium(TM) to Schering AG and announces druggability collaboration

Second large scale agreement on target druggability assessment

London, UK, 17th October 2005 - Inpharmatica Ltd, a leading provider of discovery technologies and services, today announces that scientists from Schering AG, Germany and Inpharmatica Ltd will collaborate in the area of protein structures with the aim to prioritise proteins as drug targets.

Inpharmatica will make its Biopendium(TM) as well as Chematica(TM) technologies available to Schering. The objective is to develop techniques and approaches which will support Schering AG's project prioritisation activities. This is the second such contract won by Inpharmatica and follows an agreement signed with Pfizer in January 2005 to assess druggability of a range of nominated proteins.

The financial terms of the agreement were not disclosed.

Biopendium provides comprehensive sequence annotation for over 150 organisms, making it the world's pre-eminent pre-computed, annotation database. Superior annotation is generated by moving beyond traditional text-based data to a system that incorporates pharmaceutically relevant, protein 3D structure and ligand information.

Chematica and Biopendium are integral components of Inpharmatica's gene-to-candidate technology platform which integrates biology- and chemistry-based drug discovery activities. Inpharmatica's technologies optimise target selection based on druggability, and enable rapid identification of hits and selection of high quality leads and pre-clinical candidates, which are prioritised on the basis of good drug-like characteristics and clinical indication.

Commenting on the announcement, John Lisle, CEO of Inpharmatica, said: "Target druggability assessment is essential for efficient drug development. Inpharmatica has made a significant investment in this area in recent years culminating in our first collaboration in the area earlier this year. We now look forward to this opportunity to collaborate with Schering AG in this exciting area, creating a valuable support to drug discovery decision making."

About Inpharmatica: www.inpharmatica.com

Founded in 1998, Inpharmatica uses predictive informatics in genomics, medicinal chemistry and ADME to improve the speed and productivity of drug discovery. The company employs around 100 professionals at its UK locations in London and Cambridge, with business development in North America and Japan. Inpharmatica's unique proprietary technologies and skills are utilised in major discovery laboratories worldwide including Serono, Pfizer, GSK, Novartis, Sanofi-Aventis, P&G Pharmaceuticals, and Daiichi.

Inpharmatica is unique in offering discovery technologies and services which span the full breadth of research from gene through to candidate selection: the core elements are fully integrated, enabling customers to access the full end-to-end technologies, or individual components and services as required.

For more information, please contact:

Andrew Lloyd & Associates
Andrew Lloyd / Heidi Thompson
Tel: +44 1273 675100
allo@ala.com  / heidi@ala.com

Inpharmatica Ltd
John Lisle, Chief Executive Officer
Tel: +44 (0)20 7074 4600
Dr Vimal Mehta, Sr. VP Business Development
Tel: +1 203 453 6525 

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