Malvern Instruments presentation shows power of near-infrared chemical imaging in Quality by Design

29 April 2008: Malvern, UK: A new freely downloadable presentation available via the Malvern Instruments website, highlights how SyNIRgi, the company’s powerful near infrared chemical imaging (NIR-CI) system, can provide the data and product understanding required for Quality by Design. To download the presentation visit http://www.brainshark.com/malvern/NIR-CI_pharma

‘Near infrared imaging of pharmaceuticals and Quality by Design’ looks at how this measurement technology can help answer the questions of “What? How much? And Where?” It presents a variety of applications in the pharmaceutical industry and a discussion of how to derive statistically meaningful, reproducible and quantitative results.

SyNIRgi rapidly identifies, quantifies and locates chemical species within a sample. This information provides valuable insight into product performance, optimizing design space definition and specification setting. Analytical times are short and no sample preparation is required, making the system an excellent ‘go to’ option for QbD related studies.

With SyNIRgi a researcher can track water gradients in a tablet during hydration, rather than simply monitoring average water content. The distribution of active pharmaceutical ingredients (API) can be studied to assess the efficacy of blending or interactions with excipients. Coating quality – thickness, homogeneity – can be statistically measured. In each case the result is greater product and process understanding.

SyNIRgi is fully automated with the capability to analyze powders, granules, tablets or complete blister packs, in minutes. In excess of 80,000 spectra are collected from across the surface of the sample for each measurement. Advanced statistical analysis techniques, accessed via ISys,
a user-friendly software package, extract relevant chemical and morphological information.

To download the presentation visit http://www.brainshark.com/malvern/NIR-CI_pharma

Malvern and Malvern Instruments are registered trademarks of Malvern Instruments Ltd
SyNIRgi is a trademark of Malvern Instruments Ltd

Ends
 

High resolution image attached or available from Luke Newman,
Kapler Communications luke@kapleronline.com  Ref: MAL/JOB/1409

CAPTION: SyNIRgi from Malvern Instruments

About Malvern Instruments
Malvern Instruments provides a range of complementary materials characterization tools that deliver inter-related measurements reflecting the complexities of particulates and disperse systems, nanomaterials and macromolecules. Analytical instruments from Malvern are used in the characterization of a wide variety of materials, from industrial bulk powders to the latest nanomaterials and delicate macromolecules. A broad portfolio of innovative technologies is combined with intelligent, user-friendly software. These systems deliver industrially relevant data enabling our customers to make the connection between micro (such as particle size) and macro (bulk) material properties (rheology) and chemical composition (chemical imaging).

Particle size distribution, particle shape information, zeta potential, molecular weight, chemical composition, and bulk materials properties can all be determined with instruments from the Malvern range. The company’s laboratory, at-line, on-line and in-line solutions are proven in sectors as diverse as cement production and pharmaceutical drug discovery.

Headquartered in Malvern, UK, Malvern Instruments has subsidiary organizations in all major European markets, North America, China, Korea and Japan, a joint venture in India, a global distributor network and applications laboratories around the world. www.malvern.com 

For press information, please contact:
Trish Appleton, Kapler Communications
Knowledge Centre, Wyboston Lakes, Great North Road,
Wyboston, Bedfordshire, MK44 3BY, UK
Tel: +44 (0)1480 479280; Fax: +44 (0)1480 470343 trish@kapleronline.com

USA contact:
Marisa Fraser, Malvern Instruments Inc.
117 Flanders Road, Westborough, MA 01581-1042 USA
Tel: +1 508 768 6400 Fax: +1 508 768 6403 marisa.fraser@malvern.com

Please send sales enquiries to:
Alison Vines, Malvern Instruments Ltd
Enigma Business Park, Grovewood Road, Malvern, Worcestershire WR14 1XZ UK
Tel: +44 (0) 1684 892456; Fax: +44 (0) 1684 892789 salesinfo@malvern.com