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New ‘chromatography flow-mode’ option transforms
Zetasizer Nano into in-line detector for absolute size exclusion chromatography
Launched at Pittcon 2007 (25 Feb - 2 Mar 07; Chicago,
USA) the new ‘chromatography flow-mode’ option for Malvern’s market-leading
Zetasizer Nano particle and molecular characterization system, enables its use
as an in-line chromatography detector for protein applications.
A significant new development, ‘chromatography flow-mode’ permits the coupling
of dynamic light scattering with size exclusion chromatography, conferring the
ability to perform Absolute Size Exclusion Chromatography (ASEC). This allows
protein size to be measured directly rather than relying on column calibration
or additional data from a second detector, and means that molecular weight
standards are no longer required to identify oligomeric species or determine
protein purity.
To use the Zetasizer Nano as an absolute light scattering detector it simply
needs to be connected after the last detector in a size exclusion chromatography
(SEC) system. The instrument can be added to any SEC set-up; no column
calibration is required and the Zetasizer Nano’s software makes the entire
measurement process simple and straightforward. For the majority of protein
separations in aqueous media, no extra parameters are required. Size is plotted
in real time as material is eluted from the column, and the molecular weight of
each peak is calculated automatically at the end of the measurement.
The Zetasizer Nano was designed specifically to meet the low concentration and
small sample volume requirements of protein and other biomolecular applications
and is now in widespread use. It is by applying the system’s patented optical
design and high sensitivity capabilities to real time flow measurements that
Malvern has facilitated the Zetasizer Nano’s use as a chromatography detector,
providing a major new tool for protein researchers.
www.malvern.com
Ends
High resolution image enclosed or available from Trish Appleton,
Kapler Communications
trish@kapleronline.com. Ref: MAL/JOB/1291
About Malvern Instruments
Malvern Instruments is a global company that develops, manufactures and
markets advanced analytical systems used in characterizing a wide variety of
materials, from bulk powders to the latest nanomaterials and delicate
macromolecules. Innovative technologies and powerful software produce systems
that deliver industrially relevant data enabling customers to make the
connection between micro (eg particle size) and macro (bulk) material properties
(rheology) and chemical composition (chemical imaging). Malvern laboratory,
on-line and in-line solutions are proven in sectors from cement to
pharmaceuticals and support the understanding, improvement and optimization of
many industrial processes.
Headquartered in Malvern, UK, the company has subsidiary organizations in all
major European markets, North America, China, Korea and Japan, key partnerships
in India, a global distributor network and a number of applications laboratories
around the world. www.malvern.com
For press information, please contact
Trish Appleton, Kapler Communications
Suite 2, Cressner House, 12 Huntingdon Street, St Neots, Cambs PE19 1BD UK
Tel: +44 (0) 1480 471117; Fax: +44 (0) 1480 471118
trish@kapleronline.com
USA contact:
Marisa Fraser, Malvern Instruments Inc
10 Southville Road, Southborough, MA 01772, USA
Tel: +1 508 480 0200; Fax: +1 508 460 9692
marisa.fraser@malvern.com
Please send sales enquiries to:
Alison Vines, Malvern Instruments Ltd
Enigma Business Park, Grovewood Road, Malvern, Worcestershire WR14 1XZ UK
Tel: +44 (0) 1684 892456; Fax: +44 (0) 1684 892789
salesinfo@malvern.com
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