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Zetasizer APS delivers, automated protein aggregate detection
27 May 2009: Malvern, UK: The new Zetasizer APS (Auto Plate Sampler) from
Malvern Instruments delivers fully automated measurement of protein size, with
no compromise in data accuracy or quality. An ideal solution to improve
productivity, this dynamic light scattering (DLS) system handles 96- or 384-well
microplates, transferring the sample to a closely controlled environment for
robust size characterization. Measurements within this defined environment
provide the accuracy and temperature stability needed to deliver consistent,
reliable results. The resulting data precision gives access to more
applications, particularly those requiring the detection of small amounts of
aggregates or the early onset of aggregation.
In dynamic light scattering measurements, temperature is a critical parameter. A
one degree uncertainly in the temperature can mean a 5% range of uncertainty in
the result. The Zetasizer APS automatically extracts a sample directly from its
well and then measures it within an enclosed measurement area that operates in
the range 2 to 90°C, controlled to 0.1 degree Celsius. Dual temperature controls
maintain optimal conditions within the wellplate to preserve sample integrity,
and separately within the measurement chamber. Each sample on a plate can be
measured using a different protocol and each is preserved for further
investigation. Melting point measurements can be carried out on individual
samples, each using a different range of temperatures, without affecting the
other samples in the plate.
Since the Zetasizer APS can handle virtually all commercially available
microwell plates, no special materials are needed. This avoids the use of
expensive plates with special optical properties, where re-use can be tempting
but then introduces the risk of cross-contamination. A programmable system of
rinsing the extraction needle and tubes before and after measurement also
ensures no sample cross-contamination. Two fluid inputs provide two separately
controlled rinses: a solvent and a wash. A background measurement between every
sample means that results are thoroughly tested for extra confidence.
Automation of size measurements using the Zetasizer APS enables unattended
measurement of a large number of samples without sacrificing data quality. The
temperature controlled measurement chamber allows measurement in the range of 2
to 90°C with a 0.1°C precision. Easy-to-use software provides a range of result
reports, as well as the ability to customise data output.
http://www.malvern.com/malvern/ondemand.nsf/id/SREL-7S9KAM
Malvern, Malvern Instruments and Zetasizer are registered trademarks of Malvern
Instruments Ltd
Ends
High resolution image attached or available from Trish Appleton, Kapler
Communications trish@kapleronline.com
Ref: MAL/JOB/1734
About Malvern Instruments
Malvern Instruments provides a range of complementary materials characterization
tools that deliver inter-related measurements reflecting the complexities of
particulates and disperse systems, nanomaterials and macromolecules. Analytical
instruments from Malvern are used in the characterization of a wide variety of
materials, from industrial bulk powders to nanomaterials and delicate
macromolecules. A broad portfolio of innovative technologies is combined with
intelligent, user-friendly software. These systems deliver industrially relevant
data enabling our customers to make the connection between micro (such as
particle size) and macro (bulk) material properties (rheology) and chemical
composition (chemical imaging).
Particle size, particle shape, zeta potential, molecular weight, chemical
composition and rheological properties measurements are now joined by advanced
chromatography solutions (GPC/SEC), extending Malvern’s technologies for protein
molecular weight, size and aggregation measurements, and synthetic polymer
molecular weight and distribution. The company’s laboratory, at-line, on-line
and in-line solutions are proven in sectors as diverse as cement production and
pharmaceutical drug discovery.
Headquartered in Malvern, UK, Malvern Instruments has subsidiary organizations
in all major European markets, North America, China, Korea and Japan, a joint
venture in India, a global distributor network and applications laboratories
around the world. www.malvern.com
For press information, please contact:
Trish Appleton
Kapler Communications
Knowledge Centre
Wyboston Lakes
Great North Road
Wyboston
Bedfordshire
MK44 3BY, UK
Tel: +44 (0)1480 479280;
Fax: +44 (0)1480 470343
trish@kapleronline.com
USA contact:
Marisa Fraser
Malvern Instruments Inc.
117 Flanders Road
Westborough
MA 01581-1042 USA
Tel: +1 508 768 6400
Fax: +1 508 768 6403
marisa.fraser@malvern.com
Please send sales enquiries to:
Alison Vines
Malvern Instruments Ltd
Enigma Business Park
Grovewood Road
Malvern
Worcestershire
WR14 1XZ UK
Tel: +44 (0) 1684 892456;
Fax: +44 (0) 1684 892789
salesinfo@malvern.com
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