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Researchers present new work on cohesive pharmaceutical powders using the
Morphologi G3 particle characterization system
Collaborative studies described in poster at 2009 AAPS Annual Meeting
and Exposition
See us on Booth # 813
15 October 2009: Malvern, UK: Contributing to the poster presentations at
the 2009 AAPS Annual Meeting and Exposition (8-12 November 2009: Los Angeles,
USA), researchers from Solvay Pharmaceuticals Inc and Malvern Instruments will
present details of a study to examine particle size, shape and distribution data
for equivalency testing of a highly cohesive drug substance manufactured at two
different sites.
Using Malvern’s Morphologi G3 automated image analysis system for particle
characterization, the team looked at the effects of different dispersion
conditions including dispersion pressure, foil thickness, dispersion apparatus,
and evaporative techniques. The results were compared with data from optical
microscopy and laser light scattering methods. The authors go on to discuss the
importance of method development in determining the techniques and parameters
necessary to generate reproducible and accurate data. They highlight the
usefulness of the Morphologi G3’s ability to selectively filter data, ensuring
that analyses are performed only on the particles of interest.
Automated image analysis using the Morphologi G3 offers high resolution
measurement of particle size and particle shape through direct image capture. It
delivers excellent results for a wide range of particle sizes, typically from
below 1 µm up to several thousand. It is ideal for many sample types including
those, such as dry powders, creams and gels, and particles on filters, that may
be difficult to characterize by other means.
The system will be demonstrated on the Malvern Instruments Booth # 813, together
with the latest Zetasizer systems for the measurement of proteins and nanosized
particles, and Malvern’s advanced range of Viscotek Gel Permeation/Size
Exclusion chromatography systems for protein and polymer analysis. Visitors will
be able to explore other systems in the Malvern materials characterization range
via interactive displays on the booth. Malvern specialists will be available
throughout to discuss individual material characterization needs.
www.malvern.com
Ends
Malvern, Malvern Instruments and Morphologi are registered trademarks of Malvern
Instruments Ltd
About Malvern Instruments
Malvern Instruments provides a range of complementary materials
characterization tools that deliver inter-related measurements reflecting the
complexities of particulates and disperse systems, nanomaterials and
macromolecules. Analytical instruments from Malvern are used in the
characterization of a wide variety of materials, from industrial bulk powders to
nanomaterials and delicate macromolecules. A broad portfolio of innovative
technologies is combined with intelligent, user-friendly software. These systems
deliver industrially relevant data enabling our customers to make the connection
between micro (such as particle size) and macro (bulk) material properties (rheology)
and chemical composition (chemical imaging).
Particle size, particle shape, zeta potential, molecular weight, chemical
composition and rheological properties measurements are now joined by advanced
chromatography solutions (GPC/SEC), extending Malvern’s technologies for protein
molecular weight, size and aggregation measurements, and synthetic polymer
molecular weight and distribution. The company’s laboratory, at-line, on-line
and in-line solutions are proven in sectors as diverse as cement production and
pharmaceutical drug discovery.
Headquartered in Malvern, UK, Malvern Instruments has subsidiary organizations
in all major European markets, North America, China, Korea and Japan, a joint
venture in India, a global distributor network and applications laboratories
around the world. www.malvern.com
For press information, please contact:
Trish Appleton, Kapler Communications
Knowledge Centre, Wyboston Lakes, Great North Road,
Wyboston, Bedfordshire, MK44 3BY, UK
Tel: +44 (0)1480 479280; Fax: +44 (0)1480 470343
trish@kapleronline.com
USA contact:
Marisa Fraser, Malvern Instruments Inc.
117 Flanders Road, Westborough, MA 01581-1042 USA
Tel: +1 508 768 6400 Fax: +1 508 768 6403
marisa.fraser@malvern.com
Please send sales enquiries to:
Alison Vines, Malvern Instruments Ltd
Enigma Business Park, Grovewood Road, Malvern, Worcestershire WR14 1XZ UK
Tel: +44 (0) 1684 892456; Fax: +44 (0) 1684 892789
salesinfo@malvern.com
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