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MISSION™ TRC shRNA Libraries Are Now Available as Lentiviral Transduction Particles
ST. LOUIS, MO,
and Taufkirchen, Germany, 6th October
2005-
Sigma, a division of Sigma-Aldrich Corporation
(Nasdaq: SIAL), a $1.4 billion Life Science and High Technology
company, through an exclusive agreement with The RNAi Consortium (TRC),
announces the expansion of the MISSION TRC shRNA library product lines to
include lentiviral transduction particles in addition to the previously
released purified plasmid DNA and frozen bacterial glycerol stock format.
Sigma-Aldrich is the first to market comprehensive lentiviral shRNA clone
libraries in this format, allowing researchers to quickly and efficiently
knockdown gene expression in primary, dividing, and non-dividing cells. This
new format of the shRNA clones, which target human and mouse genes for RNAi-
mediated gene silencing, allows for a faster, broader and more reliable shRNA
delivery. Virus mediated gene transduction results in higher infection
efficiency, greater success with the more "difficult" cell types and
integrates into the genome for long-term shRNA expression.
TRC is comprised of
principal investigators from world-class academic research institutions
(Massachusetts Institute of Technology, Harvard Medical School, the Broad
Institute, Whitehead Institute for Biomedical Research, Dana-Farber Cancer
Institute, Massachusetts General Hospital, Washington University, Columbia
University, and Academia Sinica) as well as corporate sponsoring institutions
(Sigma-Aldrich, Novartis, Eli Lilly, and Bristol-Myers Squibb). As a
scientific collaborator and distribution partner through agreement with MIT,
Sigma-Aldrich is working with TRC to provide the scientific community with
RNAi tools for functional genomics research specifically for gene function
discovery and the study of disease. The MISSION TRC shRNA clone libraries will
comprise a comprehensive collection of 150,000 pre-cloned lentiviral-based
shRNA vector constructs targeting 15,000 human genes (MISSION TRC-Hs1.0) and
15,000 mouse genes (MISSION TRC-Mm1.0). Design and development of the TRC
libraries is being led by the Broad Institute of the Massachusetts Institute
of Technology (MIT) and Harvard. For more information about MISSION shRNA
clone collections, please visit us online at
http://sigma-aldrich.com/rnai .
About Sigma-Aldrich:
Sigma-Aldrich is a leading
Life Science and High Technology company. The
Company's biochemical and organic chemical products and kits are used in
scientific and genomic research, biotechnology, pharmaceutical development,
the diagnosis of disease and as key components in pharmaceutical and other
high technology manufacturing. It has customers in life science companies,
university and government institutions, hospitals, and in industry. Over one
million scientists and technologists use its products. Sigma-Aldrich operates
in 35 countries and has over 6,800 employees providing excellent service
worldwide. The Company is committed to the success of its Customers, Employees
and Shareholders through leadership in Life Science, High
Technology and Service. For more information about
Sigma-Aldrich, please visit its award-winning website at
http://sigma-aldrich.com .
Media enquiries in
Europe to Northbank Communications:
Marc Egelhofer, Tel: +44 (0)1260 296505 m.egelhofer@northbankcommunications.com
At Sigma-Aldrich:
Keith Jolliff, +1-314-289-8484
Joan Suda, +1-314-286-7626
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