|
||
| |||||||
|
|
Exclusive Library Now Includes 65,000
Clones
ST. LOUIS, MO, and Taufkirchen, Germany,
19th January 2006 -
Sigma-Aldrich (Nasdaq: SIAL), a leading Life Science
and High Technology company, proudly announces the newest release of the
MISSION™ TRC shRNA
human and mouse libraries for RNA interference (RNAi)-based research. The
collection now carries approximately 65,000 shRNA vector constructs that
target 9,500 human genes and 3,400 mouse genes. The newly added libraries
include extensive coverage of the druggable genome and other highly studied
targets. Each clone is available from Sigma-Aldrich in bacterial glycerol
stock, ready-to-transfect purified plasmid DNA, and lentiviral particles for
direct transduction.
Sigma-Aldrich is the exclusive source of the TRC
shRNA libraries in the plasmid DNA and lentiviral formats. The lentiviral-based
shRNA libraries provide researchers with tools for studying gene function
and disease in standard cell lines and recognized difficult cell types, such
as primary, non- dividing, growth-arrested or terminally differentiated
cells. Such cell lines are typically not amenable to standard transfection
or genomic integration by other viral delivery systems, but they may be
transduced efficiently with lentiviral particles.
Harvard University and The Broad Institute of
the Massachusetts Institute of Technology and Design are leading the design
and development of the TRC libraries, which will be expanded on a quarterly
basis to include new gene targets. Eventually, the libraries will comprise a
comprehensive collection of 150,000 pre-cloned lentiviral-based shRNA vector
constructs targeting 15,000 human genes (MISSION TRC-Hs1.0) and 15,000 mouse
genes (MISSION TRC-Mm1.0).
About Sigma-Aldrich:
Sigma-Aldrich is a leading Life
Science and High Technology company. Our biochemical and
organic chemical products and kits are used in scientific and genomic
research, biotechnology, pharmaceutical development, the diagnosis of
disease and as key components in pharmaceutical and other high technology
manufacturing. We have customers in life science companies, university and
government institutions, hospitals and industry. More than one million
scientists and technologists use our products. Sigma-Aldrich operates in 35
countries and has 6,800 employees providing excellent service worldwide. We
are committed to accelerating the success of our customers through
leadership in Life Science,
High Technology
and Service.
For more information about Sigma-Aldrich, please visit our award-winning
website at www.sigma-aldrich.com.
This release contains forward-looking
statements relating to future performance, goals, strategic actions and
initiatives and similar intentions and beliefs and other statements
regarding the Company's expectations, goals, beliefs, intentions and the
like, which involve assumptions regarding Company operations and conditions
in the markets that the Company services. The Company does not undertake any
obligation to update these forward-looking statements.
At
Sigma-Aldrich:
Keith Jolliff, PhD, Tel:
+1-314-289-8484
Media enquiries to Northbank Communications: Marc Egelhofer, Tel: +44 (0)1260 296505 m.egelhofer@northbankcommunications.com |
|
| ||||||||
