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Acumen eX3 accelerates transfer from development to
screening
20 September 2006 Seattle, USA – TTP LabTech today initiated the second
generation of high content screening systems with the launch of the triple laser
Acumen® eX3 microplate cytometer at SBS 2006. An evolution of its highly
successful Acumen Explorer® HCS platform technology, the Acumen® eX3 is equipped
with up to three lasers at 405, 488 and 633 nm, offering a wavelength range for
excitation that is similar to that of white light source instrumentation and
significantly increasing the variety of fluorescent reagents compatible with the
system. The new Acumen® eX3 will simplify assay transfer from development to
screening laboratories by delivering the powerful object recognition of CCD
Imagers combined with the fast reads of bulk fluorescence readers.
Scanning up to 64 whole wells at a time, the Acumen range of laser-scanning
fluorescence microplate cytometers can perform cytometric analyses at
throughputs of up to 200 plates - or 300,000 data points (1536 plates) - per
day.
Putting the development of the Acumen® eX3 in context, Wayne Bowen, TTP
LabTech’s CSO said; “The Acumen Explorer® is routinely relied on for high
content screening in industry and academia because of its unique ability to
combine data collection from whole well scanning with fast read times. The
Acumen® eX3 offers huge flexibility: researchers can select the optimum laser
combination required to excite the fluorescent probes being used. Since nuclear
staining is not required to locate the cells, all probes may be used for
reporting biological responses. The upshot is that, with simultaneous four
colour detection, the Acumen® eX3’s possible performance exceeds the limits of
current multicolour, multiplexed assay protocols, giving an assurance of
future-proofing.”
The Acumen® eX3’s enhanced software gives the added flexibility of exporting
TIFF images which closely match those captured using a 20x microscope objective
for subsequent analysis by third party image analysis software. This facilitates
the seamless transfer from assay development on microscope-based CCD Imagers to
assay screening on the Acumen® eX3 with minimal changes to experimental
protocols. Flexibility is further assured since the Acumen® eX3’s functionality
can be built-up over time, starting with one laser and retrospectively adding
additional lasers, depending on user or assay requirements.
By combining the power of rapid, whole well data collection with the ability to
classify objects within cells, or sub-cellular events, the Acumen® eX3
represents a major breakthrough for microplate cytometers in the assay
development-to-screening process.
[For a high resolution image contact
David
Robinson]
ENDS
For more information visit
www.ttplabtech.com/acumen
Editors’ notes
About TTP LabTech’s Acumen range of microplate cytometers
TTP LabTech’s Acumen range of fluorescence microplate cytometers enable rapid
high content screening for applications such as protein kinase activation, cell
cycle analysis and beta-lactamase reporter gene analysis. The optics collect and
analyse data for up to 4 colours per laser simultaneously in a single scan
across the entire well area; screening adherent, non-adherent, live or fixed
cells. Typical san and analysis times are under 10 minutes a plate.
About TTP LabTech Ltd
Based near Cambridge, UK, TTP LabTech supplies custom automation and laboratory
instrumentation for the healthcare, biotech and pharmaceutical sectors. TTP
LabTech’s products are designed to increase efficiency, effectiveness,
flexibility or overall capability in key biopharmaceutical research processes
including compound storage (comPOUND®), low volume liquid handling (mosquito®)
and fluorescence detection (Acumen® fluorescence microplate cytometers).
As well as its own products, TTP LabTech undertakes the development of
outstanding custom solutions for specific needs, including automated chemistry
systems, process automation and novel instrumentation.
Date: 20 September 2006
Ref: 06TTP05
Product enquiries
TTP LabTech Limited
Sarah Payne +44 (0)1763 262626
Email: sales@ttplabtech.com
Media enquiries
Alto Marketing Limited
David Robinson +44 (0)1489 557672
Email: davidr@alto-marketing.com
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