|
| |
| |
|
 |
Thermo Expands
HeavyPeptide AQUA Range for Absolute Quantification in Proteomics |
Maximum control and precision for accelerated
results
PARIS, France (March 28, 2006) — Thermo Electron
Corporation, the world leader in analytical instruments, today announced the
expansion of its HeavyPeptide™ AQUA™ product range to enable absolute
quantification of all proteins in a sample. Thermo’s HeavyPeptide AQUA kits can
now be prepared with covalent modifications, such as phosphorylation, which are
chemically identical to naturally occurring post-translational modifications (PTMs).
As a result, the HeavyPeptide AQUA kits are an extremely cost-effective
solution, enabling researchers to identify and quantify peptides of interest
much faster, with significantly increased precision.
Thermo’s HeavyPeptide AQUA kits have been specifically designed with an
exceptional precision of ±5% for advanced techniques where there is a need for
absolute quantification. Phosphorylation modification is also available on
Thermo’s HeavyPeptide BASICTM range, which provides the perfect platform for
high-throughput, pre-quantitative screening and relative quantification. Thermo
HeavyPeptide kits include an optional control analogue of the bespoke peptides
that do not contain the stable heavy isotopes.
By allowing the addition of chemical groups to the HeavyPeptide AQUA and BASIC
kits, Thermo has answered the need for relative and absolute quantification of
the expression levels for all proteins in complex samples. This is essential
since PTMs significantly increase the size of proteomes over their corresponding
genomes. Thermo’s HeavyPeptide AQUA and BASIC ranges are powerful tools for
absolute quantification of all proteins when used with mass spectrometry
techniques such as LC-MS. Furthermore, the HeavyPeptide AQUA product range
produces a clear and consistent gain in efficiency, transparency and
reproducibility of experiments.
For more information about Thermo HeavyPeptide AQUA and BASIC, please visit
www.thermo.com/heavypeptides
1. Absolute quantification of proteins and phosphoproteins from cell lysates by
tandem MS. Scott A. Gerber, John Rush, Olaf Stemman, Marc W. Kirschner, and
Steven P. Gygi, 6940–6945, PNAS, June 10, 2003, vol. 100, no. 12 2.
www.ionsource.com
# # #
About AQUA
This method was developed by Dr.Steve Gygi and colleagues at Harvard Medical
School [Stemmann O, Zou H, Gerber SA, Gygi SP, Kirschner MW; Dual inhibition of
sister chromatid separation at metaphase, Cell 2001, Dec 14, 107:715-726] and is
the subject of both US and PCT Patent Applications. Limited non-commercial use
of this method is permitted under a licensing arrangement with Harvard Medical
School.
About Thermo Electron Corporation
Thermo Electron Corporation is the world leader in analytical instruments. Our
instrument solutions enable our customers to make the world a healthier, cleaner
and safer place. Thermo's Life and Laboratory Sciences segment provides
analytical instruments, scientific equipment, services and software solutions
for life science, drug discovery, clinical, environmental and industrial
laboratories. Thermo's Measurement and Control segment is dedicated to providing
analytical instruments used in a variety of manufacturing processes and
in-the-field applications, including those associated with safety and homeland
security. For more information, visit
www.thermo.com
Laboratory Equipment Division
Media Contact Information.
Neil Ravenhill
Alto Marketing Ltd
Phone: + 44 (0)1489 557672
E-mail: neilr@alto-marketing.com
Tara Tereso
Thermo Electron Corporation
Phone: +1 508-482-7065
E-mail: tara.tereso@thermo.com
| |
|
