Biotechnology Research

13:50 EDT 21st September 2017 | BioPortfolio

Combinatorial genome and protein engineering yields monoclonal antibodies with hypergalactosylation from CHO cells.

One of the key quality attributes of monoclonal antibodies is the glycan pattern and distribution. Two terminal galactose residues typically represent a small fraction of the total glycans from antibodies. However, antibodies with defined glycosylation properties including enhanced galactosylation have been shown to exhibit altered properties for these important biomedical modalities. In this stud...

The Complete Genome Sequence of the Actinobacterium Streptomyces glaucescens GLA.O (DSM 40922) carrying gene clusters for the biosynthesis of tetracenomycin C, 5`-hydroxy streptomycin, and acarbose.

Special Issue: 11th APCCS-2016-Chemistry, Environmental, Biotechnology and Biomedical Aspects of Chitin and Chitosan.

De novo transcriptome of the cosmopolitan dinoflagellate Amphidinium carterae to identify enzymes with biotechnological potential.

Dinoflagellates are phytoplanktonic organisms found in both freshwater and marine habitats. They are often studied because related to harmful algal blooms but they are also known to produce bioactive compounds for the treatment of human pathologies. The aim of this study was to sequence the full transcriptome of the dinoflagellate Amphidinium carterae in both nitrogen-starved and -replete culturin...

Cell wall biomechanics: a tractable challenge in manipulating plant cell walls 'fit for purpose'!

The complexity and recalcitrance of plant cell walls has contributed to the success of plants colonising land. Conversely, these attributes have also impeded progress in understanding the roles of walls in controlling and directing developmental processes during plant growth and also in unlocking their potential for biotechnological innovation. Recent technological advances have enabled the probin...

Concept for Recycling Waste Biomass from the Sugar Industry for Chemical and Biotechnological Purposes.

The objective of this study was to develop a method for the thermally-assisted acidic hydrolysis of waste biomass from the sugar industry (sugar beet pulp and leaves) for chemical and biotechnological purposes. The distillates, containing furfural, can be catalytically reduced directly into furfurayl alcohol or tetrahydrofurfuryl alcohol. The sugars present in the hydrolysates can be converted by ...

Tagging activated neurons with light.

Reply: Greener revolutions for all require transparency and diversity, not secrecy.

Shotgun metagenomics, from sampling to analysis.

Diverse microbial communities of bacteria, archaea, viruses and single-celled eukaryotes have crucial roles in the environment and in human health. However, microbes are frequently difficult to culture in the laboratory, which can confound cataloging of members and understanding of how communities function. High-throughput sequencing technologies and a suite of computational pipelines have been co...

Interpreting the T-cell receptor repertoire.

Neoantigen prediction and the need for validation.

What's app? Helix wants you to quiz your genome-some of it for fun.


Precision editing in the human embryo.

2Q17-Biotech stages a recovery.

Blood feud erupts over Roche's bispecific antibody for hemophilia.

Mouse phenotyping sheds light on rare disease.

CRISPR patent estate splinters.

Research Highlights.

Greener revolutions for all require transparency and diversity, not secrecy.

Nestlé moves into gut microbiome tests.

Podcast: First rounders: Greg Winter.

Go-ahead for first anti-IL-23 mAb to treat psoriasis.

Around the world in a month.

Recent patents related to clinical applications of sequencing.

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