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    BioPortfolio | Visiongain Conferences |  6th Annual Diabetes Conference

    6th Annual Diabetes Conference

    6th Annual Diabetes Conference


    Attenuating the progression of hyperglycaemia, dyslipidaemia and diabetic retinopathy

    21st - 22nd January 2010, BSG House, London, UK

    Background Info

    Key Speakers
    • Peter Adamson, Head of Research, Ophthiris, GlaxoSmithKline
    • Riccardo Perfetti, Senior Medical Director, Diabetes & Metabolism Global Franchise, Sanofi-Aventis
    • Richard Carr, Senior Director, Merck Sharp & Dohme
    • Rafaella Balena, Vice Director of Clinical Science & Leader of Medical Science, F. Hoffmann-La Roche
    • Ingrid Warnold,  DIRECT Project Leader and Study Delivery Director, AstraZeneca
    • Michael Trautmann, Medical Fellow, Global Exanatide Team, Lilly
    • Matthew Sheetz, Medical Fellow, Lilly
    • Piet Pijper, Global Development Project Leader, Astellas
    • Paul Ashton, President & Chief Executive Officer, pSivida
    • Stanley Wiegand, Vice President, Ophthalmology and Cardiovascular Research, Regeneron Pharmaceuticals
    • Patricia Cole, Executive Director and Head of Imagepace, Medpace
    • Didier Pruneau, Head of Scientific Operations, Fovea Pharmaceuticals
    • Anne Katrin Sjølie, Chair, DIRECT Programme Steering Committee
    • Arnd Gandorfer, Professor of Ophthalmology and Deputy Chairman, University Eye Hospital Munich
    • Victor Chong, Consultant Ophthalmologist, University of Oxford
    • Adnan Tufail, Consultant Ophthalmologist, Moorfields Eye Hospital

    Managing toxic glucose and fat concentrations in the vasculature remain significant challenges for diabetics. As the numbers of patients affected by the disease climbs, so secondary vascular and ophthalmic complications affecting patients continue to grow. With up to 50 million people currently affected by diabetic eye diseases and 100 million forecast by 20251,  more effective therapeutics are desperately needed.

    Set to double from $32bn to $64bn over the next 15 years2, the global diabetes market is set for stellar growth as changing demographics and new therapies begin entering the clinic.

    Focussing on efforts to reduce the burden of hyperglycaemia, dyslipidaemia and retinopathy, Visiongain’s 6th Annual Diabetes conference focuses on the latest developments in this area. We bring you distilled insights from outstanding speakers in key areas including:

    • Full market analysis, including medical needs and commercial opportunities
    • Novel GLP1 receptor agonists, and SLGT2 and DPP-4 inhibitors 
    • The use of biomarkers and imaging for the development of novel therapies for diabetes 
    • New therapeutic targets to reduce cardiovascular disease in type 2 diabetes 
    • Overcoming microangiopathy and capillary occlusion 
    • Epidemiology and pharmacotherapies for diabetic eye diseases 
    • The effects of ACE, RAS and PKC inhibitors on the progression of diabetic retinopathies 
    • Clinical results from the EUCLID, DIRECT and RASS studies 
    • New data on intravitreal VEGF and PLGF signalling inhibitors 
    • Corticosteroid implants to reduce intra-ocular vascular permeability and oedema 
    • Blockade of the kallikrein-kinin system to treat diabetic retinopathy 

    Who should attend?

    CEOs, Chief Scientific Officers, Chief Operating Officers, Presidents, Senior Vice Presidents, Vice Presidents, Heads, Senior Directors, Directors, Clinicians, Principal Scientists, Principal Investigators, Managers, Project/Team Leaders in:
    • Diabetes & Obesity, Clinical R&D
    • Endocrinology and Metabolic Diseases
    • Cardiovascular and Gastrointestinal Diseases
    • Anti-Diabetic Agents & Advanced Diabetes Systems
    • Biomarkers
    • Imaging and Translational Medicine
    • Drug Development
    • Ophthalmology, Visual Science and Vision Research
    • Retinal Diseases 
    • Monoclonal Antibodies
    • Translational Medicine
    • Molecular Neuroscience
    • New Products Global Marketing
    • Business Development, Licensing & Partnership
    • Venture Capital
     
    1Dodson, P.M. (2009). Management of diabetic retinopathy: could lipid-lowering be a worthwhile treatment modality? Eye, 23 (5), pp. 997-1003. 
    2Visiongain, (2009). World Diabetes Market, 2009-2023.

    Day 1

    Day One, Thursday 21st January 2010 

    09:30 Registration and refreshments

    10:00 Opening address from the Chair

    Johannes Zanzinger
    Head, Global Licensing Cardio-Metabolic Diseases
    Boehringer-Ingelheim*

    10:10 Incretin-based therapies for type 2 diabetes mellitus
    • Differences between oral agents (DPP IV inhibitors) and injectable GLP-1 receptor agonists
    • Optimising the stimulation of GLP-1 receptors and potential limitations: conclusions from FDA advisory hearings
    • Clinical efficacy of GLP-1 receptor agonists

    Michael Trautmann
    Medical Fellow, Global Exanatide Team
    Lilly
     

    10:50 Ave010: a novel GLP receptor agonist
    • Incretin action and postprandial glucose control
    • Daily treatment regimens to facilitate compliance
    • Weight control and the management of hyperglycaemia

    Riccardo Perfetti
    Senior Medical Director, Diabetes & Metabolism Global Franchise
    Sanofi-Aventis

    11:30 Morning refreshments 

    11:50 The global diabetes market: opportunities, drivers and challenges 
    • Medical needs and commercial opportunities in diabetes
    • Success rates for diabetes drug discovery and development 
    • Some exciting new opportunities for partnering

    12:30 New developments in a novel glucagon-like peptide 1 candidate
    • Effects on circulating glucose and lipid levels
    • Effects on glycosylated HbA concentration
    • Prospects for phase III studies

    Rafaella Balena
    Vice Director of Clinical Science & Leader of Medical Science
    F. Hoffmann-La Roche

    13:10 Networking lunch

    14:10 SGLT2 inhibitors for the treatment of diabetes
    • The mechanism: inhibition of renal glucose re-uptake 
    • The concept: glycaemic control through urinary glucose excretion
    • The therapeutic potential in the treatment of diabetes: benefits and risks

    Piet Pijper
    Global Development Project Leader 
    Astellas

    14:50 Imaging biomarkers in drug discovery for diabetes and complications of diabetes 
    • Obesity
    • Cardiovascular disease
    • Diabetic retinopathy

    Patricia Cole
    Executive Director and Head of Imagepace, Medpace
    Formerly Global Head of Imaging Biomarkers, Eisai Global Clinical Development


    15:30 Afternoon refreshments 

    15:50 Therapies for dyslipidaemia-induced diabetic complications

    Johannes Zanzinger
    Head, Global Licensing Cardio-Metabolic Diseases
    Boehringer-Ingelheim*

    16:30 Therapeutic targets to reduce cardiovascular disease in type 2 diabetes
    • Links between diabetes and CVD
    • Novel diabetes drugs and CVD
    • Future directions

    Richard Carr
    Senior Director
    Merck Sharp & Dohme


    17:10  Microvascular complications to diabetes, with focus on retinopathy. What is the evidence for treatment with RAS inhibitors?
    • Retinal lesions as markers of macro and microvascular complications in diabetes
    • The role of blood pressure on retinopathy
    • Evidence of the effect of RAS inhibitors on the incidence and progression of retinopathy

    Anne Katrin Sjølie
    Chair
    DIRECT Programme Steering Committee

    Ingrid Warnold
    DIRECT Project Leader and Study Delivery Director 
    AstraZeneca

    17:50 Closing remarks from the chair

    18:00 Networking drinks
    Take your discussions further and build new relationships in a relaxed and informal setting 

    Day 2

    Day Two, Friday 22nd January 2010 

    09:30 Registration and refreshments

    10:00 Opening address from the Chair

    Peter Adamson
    Head of Research, Ophthiris
    GlaxoSmithKline


    10:10 Pharmacotherapies for diabetic retinopathy
    • Overview of DR and DME 
    • Trends in diabetic eye disease rates
    • Current treatments and their shortcomings 

    Adnan Tufail
    Consultant Ophthalmologist
    Moorfields Eye Hospital
     

    10:50 Ocular drug delivery in diabetic retinopathy
    • Barriers to clinically effective therapies
    • Emerging drug delivery technologies
    • Clinical data

    Paul Ashton
    President & Chief Executive Officer
    pSivida

    11:30 Morning refreshments

    11:50 Decreasing vascular permeability with corticosteroids
    • Reducing vascular leakage
    • Inhibiting fibrovascular proliferation
    • Inhibiting TGF-β

    12:30 Development of the VEGF Trap-Eye for Treatment of Ocular Vascular Diseases
    • Molecular design, properties and preclinical evaluation of VEGF Trap-Eye
    • CLEAR-IT Phase 2 Extension: Two-year results in neovascular age-related macular degeneration (AMD)
    • Clinical Program Overview: AMD, Central Retinal Vein Occlusion, and Diabetic Macular Edema

    Stanley Wiegand
    Vice President, Ophthalmology and Cardiovascular Research
    Regeneron Pharmaceuticals 

    13:10 Networking lunch

    14:30 Microplasmin-assisted vitrectomy
    • The vitreous as a target for pharmacology
    • Pharmacology-assisted vitreoretinal surgery
    • Preclinical and clinical assessment of microplasmin 

    Arnd Gandorfer
    Professor of Ophthalmology and Deputy Chairman
    University Eye Hospital Munich

    15:10 Anti-VEGF agents for diabetic eye complications
    • Pathogenesis of diabetic retinopathy
    • Anti-VEGF for proliferative diabetic retinopathy
    • Anti-VEGF for diabetic macular oedema

    Victor Chong
    Consultant Ophthalmologist
    University of Oxford

    15:45 Afternoon refreshments

    16:10 The PKC beta inhibitor, ruboxistaurin, for diabetic retinopathy: recent results and status update  
    • Ruboxistaurin development history
    • Recent results in diabetic retinopathy
    • Ongoing studies 

    Matthew Sheetz
    Medical Fellow
    Lilly


    16:50 Blockade of the kallikrein-kinin system as a new therapeutic approach of diabetic retinopathy
    • The kallikrein-kinin system (KKS) 
    • Role of the KKS in diabetic retinal inflammation 
    • Development of a kinin B1 receptor antagonist administered topically

    Didier Pruneau
    Head of Scientific Operations
    Fovea Pharmaceuticals


    17:30 Chair’s closing remarks 

    17:40 End of conference 


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