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BioPortfolio | Jain PharmaBiotech Reports | Biomarkers - technologies, markets and companies

Biomarkers - technologies, markets and companies

This report follows the broad definition of a biomarker as a characteristic that can be objectively measured and evaluated as an indicator of normal biological or pathogenic processes as well as pharmacological responses to a therapeutic intervention. Tests based on biomarkers have been around for more than half a century, but interest in their application for diagnostics and drug discovery as well as development has increased remarkably since the beginning of the 21st century. This report describes different types of biomarkers and their discovery using various “-omics” technologies such as proteomics and metabolomics. Molecular diagnostics technologies are used for the discovery of biomarkers and new tests are also based on biomarker.

Currently the most important applications of biomarkers are in drug discovery and development. The role of biomarkers in various therapeutic areas particularly cancer, cardiovascular diseases and disorders of the central nervous system, is described. Biomarkers are useful not only for diagnosis of some of these diseases but also for understanding the pathomechanism as well as a basis for development of therapeutics.

Biomarkers will facilitate the combination of therapeutics with diagnostics and will thus play an important role in the development of personalized medicine. Biomarkers play a role in use of pharmacogenetics, pharmacogenomics and pharmacoproteomics for development of personalized medicine.

Many of the regulatory issues concerning biomarkers are related to genomics, proteomics, molecular diagnostics and pharmacogenomics/pharmacogenetics. Validation of biomarkers and their role in clinical trials is discussed.

Biomarker markets are estimated from 2007 to 2017 according to share of markets for various technologies and applications: proteomics, metabolomics, molecular diagnostics, drug discovery, clinical trials, and bioinformatics. Market values are further split according to therapeutic applications and major geographical areas. Unfulfilled needs in biomarkers are identified as well as the drivers for biomarker markets. Challenges facing the biomarker industry and strategies for developing biomarker markets are discussed.

A large number of companies with varying technical backgrounds are involved in biomarkers and 222 of these are profiled in part 2 of the report with classification into various categories.These also include major pharmaceutical companies. There is tabulation of 483 collaborations between companies and additional academic collaborations are mentioned in the individual profiles of companies.

Table of contents

Introduction to biomarkers

Technologies for Discovery of Biomarkers

Biomarkers and Molecular Diagnostics

Biomarkers for Drug Discovery and Development

Role of Biomarkers in Various Diseases

Biomarkers in Cancer

Biomarkers of Neurological Disorders

Biomarkers of Cardiovascular Disorders

Biomarkers and Personalized Medicine

Regulatory issues

Markets for Biomarkers

Companies

August 2009.. 939 Pages, Tables 57, Figures 12, Companies 259, Alliances 483, References 750

Table of Contents
Full Table of Contents (doc)

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