Combinatorial Chemistry Course

Course Description

The course introduces the use of combinatorial chemistry for drug discovery. It covers the requirements for performing combinatorial chemistry, the design and synthesis of combinatorial libraries, and molecular diversity analysis as applied to antibodies, peptides, nucleic acids, and small molecules.

Course Objectives:

> Define the two technologies that now allow the creation of large combinatorial libraries of compounds

> List the three functions that combinatorial chemistry brings to synthetic medicinal chemistry

> Describe the difference between the three different types of assays with which combinatorial libraries are usually tested

> Specify two of the features of an assay that allow it to be amenable to high-throughput screening

> Explain the advantages of HTRF-based assays

> Describe the three principal requirements needed to scale an assay to the level of uHTS

> Define the difference between a diverse library and a focused or biased library

> Calculate the number of combinations of molecules capable of being created from an n-mer peptide library

> List three classes of proteins that have been "improved" using DNA shuffling

> Specify the strategic options available in the creation of a combinatorial library

> Describe how molecular diversity can be obtained in protein, peptide, nucleic-acid or small-molecule libraries

> Define and explain the two major strategies for synthesizing small-molecule libraries

> List the nine steps involved in creating antibodies via phage display

> Understand the key features of a drug pharmacophore

> List some of the parameters involved in designing combinatorial drug libraries

> Define the two major parameters in drug optimization that can benefit from drug design

> Give two examples of drugs that can now be synthesized by solid-phase combinatorial synthesis

Course Outline:

Introduction

1. Course Description

Combichem Overview

2. Objectives

3. Medicinal Chemistry

4. Combinatorial Chemistry

5. High-Throughput Screening

6. HTS Assays

7. uHTS Requirements

8. Progress Check

Diversity Analysis

9. Objectives

10. Selection and Diversity

11. Peptide Libraries

12. DNA Shuffling

13. Strategic Options

14. Molecular Diversity

15. Synthesis Strategies

16. Phage Display

17. Progress Check

Library Design

18. Objectives

19. Drug Pharmacophores

20. Library Design

21. Lead Optimization

22. Applications

23. Progress Check

Conclusion

24. Final Assessment

Each Online Training Course or Professional Designation Program listed below comes complete with;

> 24 hour access to the course for 90 days,

> a printable PDF file including the notes to the course,

> a test used to measure your understanding of the material provided in the course, and

> a Certificate of Completion once you have passed a course, or;

> a Certificate of Professional Designation if you are enrolling in a Professional Designation program
Course Unit 4 of 6 units
Price: $145.00 / GBP75.40