Epilepsy Pipeline drugs struggle to outshine their marketed predecessors

Introduction

Slow generic uptake, reformulations, follow-on products and new market entrants will ensure steady long-term growth of the epilepsy market despite several high profile patent expiries. UCB has emerged as the number one epilepsy company, and is set to strengthen their epilepsy pipeline if the proposed acquisition of Schwarz is confirmed.

Scope of this report

Analysis of patient potential, unmet needs and clinical trial design in epilepsy

Overview of drugs in pre-registration, Phase III, II and I; with analysis of key companies involved in the market

Detailed profiles of key compounds in development for use in epilepsy, with forecasts of drug revenues to 2015

Discussion of UCB, Eisai, and GSK's strategies and insight from key industry opinion leaders

Research and analysis highlights

Following on from Keppra's commercial success, UCB is the current epilepsy market leader. UCB's existing relationship with neurologists will bode well for the potent follow-on compounds, brivaracetam and seletracetam.

UCB's proposed acquisition of Schwarz will further boost its epilepsy pipeline and CNS marketing/sales capabilities. If the acquisition is completed, Datamonitor believes that UCB will continue to develop Schwarz's Phase III pipeline product lacosamide.

Generic incursion in the epilepsy market is less profound than in other CNS sectors. Nevertheless, lifecycle management strategies will be necessary to maintain market share following patent expiries. For example, development of sustained release/extended release formulations such as GSK's Lamictal XR can slow generic incursion.

Key reasons to read this report

Understand unmet needs in the epilepsy market based on key opinion leader comments

Benchmark key late-stage epilepsy compounds against current market leaders

Assess the global (US, Japan, five major EU) sales forecasts of key late-stage pipeline drugs; and examine their clinical and commercial potential

Published: 25 October 2006

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