Introduction to Biopharma - Applications Course

Course Description:

This course describes computer-assisted drug design, introduces protein-based therapeutic agents, and describes the type of approaches used to treat immune-related diseases. This course describes the use of computer-based methods for designing new drugs and optimizing drug libraries and leads, introduces the design and use of protein based therapeutic agents, and introduces the immune system and immune related diseases.

Course Objectives:

> Define a drug pharmacophore and describe its key features.

> List three of the parameters involved in designing combinatorial libraries.

> Define which two parameters in drug optimization can be improved by design.

> Give two examples of drugs that have been synthesized by solid-phase combinatorial synthesis.

> Specify three major applications of protein design.

> Define what site-directed mutagenesis is and how it is utilized.

> Describe how peptidomimetics are designed.

> Explain how monoclonal antibodies are generated.

> Specify which parts of an antibody molecule are modified to humanize it.

> List three ways in which antibodies are utilized for therapeutic purposes.

> Specify the four disease groups that have an immune component involved in their pathology.

> List the cells and proteins involved in eliciting an immune response.

> Understand the different mechanisms by which the immune response responds to and eradicates infectious agents from the body.

> List four approaches for generating vaccines.

> Explain how the immune system can be manipulated to treat autoimmune diseases.

> List five common autoimmune diseases.

Course Outline:

Introduction

1. Course Information

2. Interface Tour

3. Course Overview

Computer-Assisted Drug Design (CADD)

4. Objectives

5. CADD Overview

6. Drug Pharmacophores

7. Library Design

8. Lead Optimization

9. Progress Check

Protein Therapeutics

10. Objectives

11. Protein Design

12. Protein Engineering

13. Antibody Structure

14. Therapeutic Peptides

15. Monoclonal Antibodies

16. Antibody Engineering

17. Antibody Therapeutics

18. Progress Check

Immunity and Disease

19. Objectives

20. Immunity and Disease

21. Immune Response

22. Vaccines

23. Vaccine Examples

24. Applications-Influenza

25. Applications-Autoimmune Disease

26. Progress Check

Conclusion

27. Summary

28. Final Assessment

Each Online Training Course or Professional Designation Program listed below comes complete with;

> 24 hour access to the course for 90 days,

> a printable PDF file including the notes to the course,

> a test used to measure your understanding of the material provided in the course, and

> a Certificate of Completion once you have passed a course, or;

> a Certificate of Professional Designation if you are enrolling in a Professional Designation program
Course Unit 3 of 3
Price: $105.00 / GBP54.60