Anti-addiction Therapies, 2006-2011 - The Pharmaceutical Industry’s Next Viagra?

1. Executive Summary

2. Introduction
2.1 Drug Addiction/Abuse/Dependency Definitions
2.2 The Development of Drugs Specifically for Treating Addiction
2.3 Maintenance Treatment is Controversial
2.4 Objectives, Methodology and Scope

3. The Physiology and Psychology of Addiction
3.1. Addiction Affects Many Areas of the Brain
3.2. Dopamine is Key
3.3. GABA Imbalance Incites Craving
3.4. The Psychology of Addiction

4. Regional Prevalence of Addiction
4.1 The Economic Cost of Addiction
4.2 Drug Dependency Low, But Severe Hazard
4.3 Alcohol Dependency Increasing Despite Health Consequences
4.4 Smoking Prevalence Causes Highest Fatality Rates From Dependency
4.5 Associated Problems Increase With Gambling Increase

5. Drug Addiction
5.1 Heroin – The Most Serious of all Addictions?
5.2 What Happens When Heroin is Taken?
5.2.1 Withdrawal Symptoms
5.3 Drug Addiction Treatments
5.3.1 Opioid Addiction Has Well Tried Treatments
5.4 Opioid Dependence Treatment Regimes
5.5 Naltrexone Implants Remain Expensive
5.6 Cocaine Addiction Looks To Future Success
5.7 Cocaine Treatment – A Vaccine Available Soon?
5.7.1 Drugs to reduce symptoms of cocaine abstinence or craving
5.8 Market Outlook For Drug Addiction Treatments
5.8.1 Cocaine Addiction Treatments Hold Greatest Promise

6. Alcohol Addiction
6.1 The Effects and Problems Associated With Alcohol
6.2 Alcohol dependency tests
6.3 Alcohol Addiction Treatments
6.3.1 Antabuse – Available Since 1948
6.3.2 Naltrexone Now Available in Injectable Form
6.4 Campral Offers Another Mode of Action for Alcohol Dependency Treatment
6.5 Most Recent Alcohol Dependency Drug From J&J
6.6 Serotonergic Agents Show Limited Usefulness
6.7 Drug treatment for related disorders
6.8 Market Outlook For Alcohol Dependency Treatments

7. Smoking Addiction
7.1 How to assess the level of nicotine addiction?
7.2 Smoking Addiction Treatments
7.2.1 Chantix is the Latest Anti-smoking Treatment
7.2.2 NRT Dominates Smoking Treatment Therapies
7.2.3 Zyban Provides Effective Treatment
7.3 Beneficial Effects Are Quickly Noticeable
7.4 Withdrawal Effects Are Also Quickly Noticeable
7.5 Market Outlook for Nicotine Dependency Treatments

8. Gambling Addiction
8.1 Gambling Addiction Treatments
8.1.1 Opioid Antagonists (OA)
8.1.2 Selective Serotonin Reuptake Inhibitors (SSRIs)
8.1.3 Mood Stabilisers
8.1.4 Other Pharmaceutical Treatment Options for Gambling Treatment
8.2 Market Outlook for Gambling Addiction Treatments

9. Obesity and Food Addiction
9.1 Obesity and Food Addiction Treatments
9.2 Will Acomplia Accomplish More?
9.3 Other Opportunities For Obesity Treatment
9.3.1 Hormone Treatment Greeted With Optimism
9.4 Market Outlook for Obesity Treatments

10. World Market by Region
10.1 Drivers and Restraints
10.2 The US Market Presents Considerable Opportunities
10.3 The Japanese Market May Accept Treatments on a Limited Scale
10.4 US Market Is Surprisingly Undeveloped For Addiction Treatments

11. Unmet Needs in Addiction Treatments
11.1 Pipeline Products for the Treatment of Drug Addiction
11.2 Fulcrum’s Link With Celtic Could Produce Novel Addiction Therapies
11.3 Genetic Link Between Disorders Inspires Further Research
11.4 Drug addiction
11.4.1 Opioid Addiction
11.4.2 Cocaine Addiction
11.5 Alcohol Addiction
11.6 Smoking Addiction
11.7 Grants From the US NIDA Used to Develop Nicotine Vaccination
11.8 Gambling Addiction
11.9 Obesity Food Addiction – Huge Interest in Potentially Lucrative Market

12. Sanofi-Aventis: A Review
12.1 The Takeover of Aventis By Sanofi was Aggressive
12.2 Sanofi-Aventis Continues to Expand

13. Conclusion

Table 5.1 A Comparison of the Heroin Dependency Treatment Options
Table 7.1 Leading Available NRT Products
Table 7.2 Beneficial Effects of Smoking Cessation
Table 7.3 The Duration of Smoking Withdrawal Effects
Table 7.4 World Revenue ($m) for Chantix, 2005-2011
Table 9.1 World Revenue ($m) for Acomplia, 2005-2011
Table 10.1 Leading Drugs For The Addiction Treatment Markets
Table 10.2 World Revenue ($m) and Growth Rate (%) of the Obesity Treatment Market, by Region, 2005
Table 10.3 World Revenue ($m) and Growth Rate (%) of the Nicotine Addiction Treatment Market, by Region, 2005
Table 10.4 World Revenue ($m) and Growth Rate (%) of the Alcohol Dependency Treatment Market, by Region, 2005
Table 11.1 Pipeline Products For Anti-Drug Addiction Treatments
Table 11.2 Pipeline Products for Cocaine Addiction Treatment
Table 11.3 Pipeline Products for Alcohol Dependency Treatment
Table 11.4 Pipeline Products for Obesity Treatment
Table 11.5 Pipeline Products for Gambling Addiction
Table 11.6 Selected Key Pipeline Products For Obesity Treatment


Figure 1.1 World Revenue ($m) for Acomplia, 2005-2011
Figure 6.1 Alcohol Consumption in Young Adults (18-29 years)
Figure 6.2 Percentage of Children Aged 15-16 Drunk Over 20 Times in Lifetime
Figure 7.1 World Revenue ($m) for Chantix, 2005-2011
Figure 9.1 World Revenue ($m) for Acomplia, 2005-2011
Figure 10.1 Market Share (%) for Obesity Treatments by Region, 2005
Figure 10.2 Market Share (%) for Nicotine Addiction Treatments by Region, 2005
Figure 10.3 Market Share (%) for Nicotine Addiction Treatments by Region, 2005