Early Toxicology Markets and Approaches
Chapter One: Executive Summary
State of Drug Discovery in 2007
Toxicology Measurement Issues
Alternative Approaches to Early Tox
About This Report
Market Overview
Chapter Two: Pharma Strategies and Toxicology
Tactics
Abbott: Developing Their Own Tools
Bristol-Myers Squibb: Reducing Drug Attrition
Eli Lilly: Safety, Toxicity, and the FDA
Glaxo SmithKline: Promoting Productivity
Johnson & Johnson: Alliances and Biomarkers
Novartis: Cheminformatics & Model building
Pfizer: Multiple approaches
Wyeth: Hitting Their Targets
Chapter Three: In Silico Approaches: Databases and Modeling
Background
Databases
Data Mining and Analysis
In-Silico Modeling
Standard Tests
Commercial Modeling Products
Advanced Chemistry Development (ACD)
Bio-Rad
GeneGo
Fujitsu Biosciences
Gene Logic
IDBS
Inpharmatica
Simulations Plus
Predicting Toxicity with QSARs and Expert Modeling Systems
Government Agency and Public Initiatives
EPA’s NCCT
FDA
ToxCheck
ChemBench
In-Silico Markets in Early Tox
Chapter Four: In Vitro Assays & Platforms
Biochemical Assays & Systems
Assays
BD Biosciences
Promega’s
Invitrogen
Systems
Beckman Coulter
Tecan
Molecular Devices
Hamilton
NIMBUS Biotechnology
Cellular Assays & High-Content Screening (HCS)
HCS Platforms
Cellomics
Beckman
GE Biosciences
CompuCyte
Imstar S.A.
Assays
Cellomics
GE Biosciences
Exelixis
Caliper
Promega
Toxicogenomics
High Throughput Genomics
Gene Logic
Gentronix
Iconix
New Technologies & Approaches
ACEA Biosciences
Amphioxus Cell Technologies
ACEA Biosciences
Cellartis AB
VistaGen Therapeutics
ESA
High Throughput Genomics
Hurel
InvivoSciences LLC
Qualyst
Solidus Biosciences
Others (Cytomyx Ltd, Cyprotex, CreaCell, Neurion, ChanTest)
Markets for In Vitro Early Tox Products
Biochemical Assays
Cellular Assays
Instruments and Platforms
Chapter Five: In-Vivo Testing: Animal Models & Human Microdosing
Animal Models
Traditional Animal Models
Zebrafish
Role in Drug Discovery Testing
Applications in Toxicology
Charles River Laboratories
Daniolabs
Phylonix
Zygogen
Other Animal Models
Rat Models—Hepaticus, Inc.
Mouse Models—University of North Carolina
Caenorhadbitis elegans--Affymetrix
Caenorhadbitis elegans-- NemaRx
Drosophila—Indiana University
Drosophila—Affymetrix
Human Microdosing
Markets for In-Vivo Products
Chapter Six: Service Suppliers
Customers for Early Tox Services
Suppliers of In Silico Services
Suppliers of In Vitro Testing Services
Product Suppliers That Provide In Vitro Services
Suppliers of Animal Testing Services
Suppliers of Services Using Traditional Animals
Suppliers of Services Using Zebrafish
Suppliers of Services Using Transgenic Rodents
Service Supplier Markets for Early Tox
Chapter Seven: Expert Views on Early Tox
General Questions
ADMET has been treated like a single subject. Is there any merit in considering
early tox separately from ADME?
What are the most important things early tox should tell you?
Which potential problems and what organ systems should early tox address?
What are the factors that have made early tox so difficult to deal with?
In-silico, In-vitro, In-vivo: Which of these three areas hold the most promise?
If early tox predictions could be made with better than 75% accuracy, how would
this impact drug discovery?
What approach(s) do you use in your early tox work?
How large is the market for early tox? How fast is it growing?
Questions About In silico Approaches
Which in-silico models have been most effective predictors?
Who are the leading suppliers of models for early tox?
Which new models should capture our attention?
Which databases are most useful?
How important is data sharing between companies (consortiums)?
Questions About In vitro Approaches
How important are cellular assays and HCS for early tox work?
Will they displace traditional biochemical assays for early tox?
What is the role of toxicogenomics in early tox?
Will chip assays displace microplate assays as the method of choice?
What are the hottest new approaches to in-vitro early tox?
Questions about In Vivo Approaches
Which animal models are most useful in early tox?
Will zebrafish assays replace more costly rodent models?
What are the advantages and limitations of zebrafish models?
What role do you expect human microdosing to play in drug discovery?
What impact will microdosing have on early tox?
Chapter Eight: Company Profiles
Accelrys
Company Background
Financials
Product Lines
Products and Approach for Early Tox
Approaches to Market
ACEA
Company Background
Technology & Product Description
Applications
Approaches to Market
Albany Molecular Research Inc. (AMRI)
Company Focus
Financials
Chemistry Services
ComGenex Acquisition
Future Opportunities & Challenges
Amphioxus Cell Technologies (Stem Cell Innovations)
Company Background
Technology
Products and Services
Approach to Market
BD Biosciences
Becton Dickenson
BD Biosciences
Products for Early Tox
Plastic Disposables
ADME/Tox Products & Services
BD Bioimaging Systems
Approach to Market
Beckman Coulter, Inc.
Company Overview
Business Areas
Financials
Biomedical Research, Drug Discovery, ADMET Products
Approach to Market
Bio-Rad Laboratories
Company Description
Financials
Life Science Research Products
Informatics / Sadtler Group
KnowItAll Cheminformatics System
Caliper Life Sciences (formerly Zymark)
Background & History
Financials
Instrument Systems for Automation
Caliper Discovery Alliances & Services (CDAS)
Cambridge Cell Networks
Background
Products & Services
The Buzz on ToxWiz
CeeTox
Background & Focus
Technology and Toxicity Testing Services
Early Tox Services
Future
Cellartis
Background
Technology & Products
Cellomics
Company History
HCS Products
Cellomics Alliances and Future
Charles River Laboratories
Overview & Focus
Financials
Research Models and Services
PreClinical Services
Future Directions
CompuCyte
Company Focus
CompuCyte Products
LSC Technology and Use in Drug Discovery
iCyte Applications in Toxicology
Elsevier MDL
Company History & Focus
Drug Discovery Product Lines
Collaborations
GE Healthcare Bio-Sciences (formerly Amersham Biosciences)
About GE Healthcare
About GE Healthcare Bio-Sciences
Products for Early Tox
LEADseeker
IN Cell Platforms
Reagents & Early Tox Applications
Approach to Market
Gene Logic
Background & History
Gene Logic Re-Invented
Financials
Genomics & Toxicogenomics Products & Services
Future
High Throughput Genomics
Company Focus
Technology
Products & Services
Applications
Hurel Corporation
Company Focus
Technology and Applications
Iconix Biosciences
Company History & Focus
Technology & Products
Partnerships & Alliances
Future Opportunities
ID Business Solutions Ltd. (IDBS)
Background & History
Areas of Focus
Drug Discovery Products
Approach to the Market
Invitrogen
Background & History
Areas of Focus
Financials
Invitrogen Contract Services & BioReliance
Assays & Reagents for Drug Discovery
Approach to the Market
Phylonix
Company Background
Phylonix Services
PreClinOmics
Company History & Focus
Technology, Products & Services
Benefits & Collaborations
Promega
Company Focus
Product Lines and Early Tox
Applications Support
Approach to Market
Qualyst
Background & History
B-Clear System Technology
Commercial Products & Services
Simulations Plus
Background & History
Financials
ADME Prediction Software
Solidus Biosciences
Background
Technology
Future Plans
Xceleron
Background
Technology & Rationale
Applications & Services
Marketing & Future
Zygogen
Company Background
Technology
Applications, Advantages & Products
Affililiations & Expansion