Immunotherapy in Oncology: Drug Pipeline Update 2008

Drug Pipeline Update at a Glance

Investigators	Includes more than 340 principal investigators plus their collaborators. There is direct access from inside the application to web pages of all principal investigators. Note: You are able to sort and find drugs according to investigators and partners from drop-down menus in the application. You may also sort and find drugs according to country of investigator.
Drug name & Synonyms	Lists commercial, generic and code names for drugs. In all more than 1,200 names
Developmental stage	This Drug Pipeline Update contains more than 850 immunotherapy drugs in active development and more than 1,730 developmental projects: 53 marketed drugs > 100 projects in Phase III > 490 projects in Phase II > 360 projects in Phase I > 630 projects in Preclinical Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application.
Indications	Included immunotherapy drugs are in development for over 150 indications, where of 60+ are different cancer indications. All drugs are in development for the treatment of cancer. Note: You are able to sort and find drugs according to type of indication from drop-down menu in the application.
Targets	Identified drugs are linked to more than 264 different targets, divided into 49 classifications of molecular function: - Acid phosphatase activity - Auxiliary transport protein activity - Carboxypeptidase activity - Catalytic activity - Cell adhesion molecule activity - Chemokine activity - Cofactor binding - Complement activity - Cytokine activity - DNA binding - DNA topoisomerase activity - DNA-directed DNA polymerase activity - Extracellular matrix structural constituent - G-protein coupled receptor activity - Growth factor activity - Hormone activity - Hydrolase activity - Intracellular ligand-gated ion channel activity - Kinase activity - Kinase binding - Kinase regulator activity - Ligand-dependent nuclear receptor activity - Ligase activity - Lipid phosphatase activity - Metallopeptidase activity - MHC class I receptor activity - Molecular function unknown - Oxidoreductase activity - Peptidase activity - Peptide hormone - Protease inhibitor activity - Protein binding - Protein serine/threonine kinase activity - Protein-tyrosine kinase activity - Receptor activity - Receptor binding - Receptor signaling complex scaffold activity - Receptor signaling protein serine/threonine kinase activity - RNA-directed DNA polymerase activity - Serine-type peptidase activity - Structural constituent of cytoskeleton - T cell receptor activity - Transcription factor activity - Transcription regulator activity - Translation regulator activity - Transmembrane receptor activity - Transmembrane receptor protein tyrosine kinase activity - Transporter activity - Unclassified Identified targets are categorized into 20 different primary and alternate sub-cellular localizations: - Cell surface - Centrosome - Clathrin-coated vesicle - Cytoplasm - Cytoplasmic vesicle - Cytoskeleton - Endoplasmic reticulum - Endosome - Extracellular - Extracellular matrix - Golgi apparatus - Integral to membrane - Lysosome - Mitochondrion - Nucleolus - Nucleus - Perinuclear vesicle - Plasma membrane - Secreted - Secretory granule Note: You are able to sort and find drugs according to target gene name, molecular function of target, and target localization from drop-down menus in the application.
Target Expression Profile	Direct links are provided from inside the application to 135 protein expression profiles of 112 drug targets in various human tissues and cancer types, cell lines and primary cells, including up to: - 48 different normal tissue types - 20 different types of cancer - 47 cell lines - 12 samples of primary blood cells
Pathway Referals	Identified targets have been cross referenced against their invovlement in different cellular pathways, according to BioCarta, KEGG and NetPath. - BioCarta 204 Pathways - KEGG 72 Pathways - NetPath 19 Signaling Pathways Note: You are able to sort and find drugs according to targeted pathways from drop-down menues in the application.
Mechanism	In total there are more than 260 different drug mechanism of action represented in this Drug Pipeline Update. Note: You are able to sort and find drugs according to mechanism of action from drop-down menu in the application.
Compound	Identified drug compounds are described by: Compound type, Chemical name, CAS Number and molecular weight Note: You are able to sort and find drugs according to compound type from drop-down menu in the application.
Drug Profile	Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information: Drug Name & Synonyms Presentation of drug name and synonyms Principal Investigator & Partners Presentation of principal investigator and partners Target and Molecular Function of Target Described target(s) is/are presented with: Official Gene Symbol - Official Gene Name [Species/Homo Sapiens] - Molecular Function Target Localization Described target(s) is/are presented with primary and alternate localizations. Target Expression Profiles Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to: 48 different normal tissue types 20 different types of cancer 47 cell lines 12 samples of primary blood cells Targeted Pathways Described target(s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, and NetPath. Mechanism Drug mechanism of action Developmental Projects Summary field of developmental projects for the drug, including indication, developmental stage and status. Example: Cancer, myeloma - Phase II Clinical Trial - Active Cancer, prostate - Phase III Clinical Trial - Ceased Drug Description Short introduction to drug Compound Data Compound type, Chemical name, CAS Number and molecular weight Patent Data Available patent information related to the drug is presented here. Business & Markets Collaborations and deals Approvals and submissions Analyst comments Phase III Data Available Phase III development data, developmental history and scientific data. Phase II Data Available Phase II development data, developmental history and scientific data. Phase I Data Available Phase I development data, developmental history and scientific data. Preclinical Data Available preclinical development data, developmental history and scientific data. Licensing Information Availability for licensing
Application Features	Use 13 different parameters, available in drop-down menus, to find and sort among drugs - Drug status - Clinical Trial Status - Principle Investigator - Partners - Indication - Developmental Stage - Compound Type - Mechanism - Target - Molecular Function of Target - Target Localization - Targeted Pathways - Free text search of entire drug profile contents Direct linkage from inside the application to related internet resources - Drug data is linked to search engines like Google and PubMed - Drug target data is linked directly to BioCarta, Human Protein Atlas, KEGG, and NetPath - Direct links to company web pages of principal investigators Export and sharing of information - Found information is easily shared with others over e-mail, file export (xls) or in print
System Requirements	- AMD-Athlon/Pentium II PC - Windows 98/NT4/2000/ME/XP/VISTA - 8x-speed CD Rom drive - SVGA 16 bit display. (32 bit recommended) - 32 MB of available RAM (128 MB recommended) - Internet access (for related internet resources)